Abstract:
:Adenosine is an endogenous cardioprotective substance. The present study examines whether exogenous adenosine attenuates cardiac injury induced by oxidative stress. Rat hearts (Langendorff model) were perfused with H2O2 (180 microM) for 10 min, then recovered for 60 min (n = 10). In other groups adenosine 55 microM, 11 0 microM, or 220 microM (n = 10 in each) was given in addition to H2O2 throughout perfusion. Control perfusion with Krebs Henseleit only (n = 7), adenosine 110 microM throughout perfusion (n = 7), and adenosine 110 microM as an intervention (n = 7) was performed. The hearts were paced at 320 beats/min. Left ventricular systolic (LVSP) and end-diastolic (LVEDP) pressures were measured together with coronary flow (CF), and left ventricular developed pressure (LVDP = LVSP - LVEDP) was calculated. H2O2 decreased LVSP from 105 +/- 8 to 60 +/- 5 mmHg (mean +/- SEM) after 10 min infusion (p < 0.008). Adenosine did not attenuate the decrease of LVSP. LVEDP increased from 0 to 59 +/- 10 mmHg (p < 0.004) and 62 +/- 11 mmHg 5 and 15 min after end of infusion of H2O2, respectively. Neither 55 microM nor 220 microM adenosine inhibited the H2O2-induced increase of LVEDP. Adenosine 110 microM attenuated the increase after 15 (15 +/- 4 mmHg, p < 0.004) and 25 min observation (26 +/- 7 mmHg, p < 0.012). Adenosine did not attenuate the reduction of LVDP. CF initially increased during infusion of H2O2, thereafter decreased. Hearts given adenosine had higher basal CF, and CF did not increase after H2O2. Control perfusion with adenosine, given throughout perfusion or as an intervention, increased CF and tended to increase LVSP. In summary, adenosine did not inhibit H2O2-induced depression of contractility or reduction of CF. One concentration of adenosine (110 microM) attenuated H2O2-induced impairment of relaxation. Exogenous adenosine does not have an important influence on functional injury caused by exogenous oxidants.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Valen G,Vaage Jdoi
10.3109/10715769609087997subject
Has Abstractpub_date
1996-01-01 00:00:00pages
31-38issue
1eissn
1071-5762issn
1029-2470journal_volume
24pub_type
杂志文章abstract::The present study has been designed and carried out to investigate the protective role of taurine (2-aminoethanesulphonic acid) against NaAsO(2) induced nephrotoxicity. Oral administration of arsenic increased the productions of ROS and RNS, enhanced lipid peroxidation, protein carbonylation and decreased intracellula...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760903164998
更新日期:2009-10-01 00:00:00
abstract::Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600978831
更新日期:2007-02-01 00:00:00
abstract::The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping techniq...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769709065781
更新日期:1997-10-01 00:00:00
abstract::γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2015.1040788
更新日期:2015-01-01 00:00:00
abstract::The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked whether sublethal and weakly lethal photic stress, induced by irradiation of ARPE-19 cells containing phagocytised LFG, affected the cell...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1380307
更新日期:2017-10-01 00:00:00
abstract:PURPOSE:Ionizing radiation generates free radicals and reactive oxygen species that induce DNA damage in vivo. This study aimed to determine the relationship between serum reactive oxygen metabolite (ROM) levels and skin reaction after irradiation in a rat model. METHODS AND MATERIALS:I. Female Wistar rats were classi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.894637
更新日期:2014-05-01 00:00:00
abstract::In the present study we tested the ability of different antioxidant agents, used alone or in combination, to reduce the reactive oxygen species (ROS) levels and to increase the glutathione peroxidase (GPx) activity. Moreover, we tested the ability of such antioxidant agents to reduce the serum levels of proinflammator...
journal_title:Free radical research
pub_type: 杂志文章
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abstract::To solve the problems faced in clinical use of hypocrellins, a water-soluble preparation of Hypocrellin B (HB), HB-Triton X-100 (TX-100) micelles, was prepared. To evaluate the photodynamic activity, the free radicals (*OH and HB*-) and singlet oxygen (1O2) generated via photosensitization of the preparation in aqueou...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001601056
更新日期:2003-10-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2010.515220
更新日期:2011-02-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600632545
更新日期:2006-07-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715760410001727858
更新日期:2004-08-01 00:00:00
abstract::Exposure of dry powder forms of the drugs nitrendipine, nifedipine, felodipine, and nimodipine to gamma-radiation results in the formation of free radicals detected by electron paramagnetic resonance (EPR) spectroscopy. The four structurally related drugs show qualitatively identical EPR spectral features in terms of ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300791
更新日期:1999-09-01 00:00:00
abstract::G72 has been characterised as a susceptibility gene that can have wide-ranging effects in a number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is a potential serum biomarker for schizophrenia. Previous transcriptomic and biochemical studies have indicated th...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1504293
更新日期:2018-09-01 00:00:00
abstract::We have reported previously that the apparent rate of peroxynitrite (ONOO(-) ) decay, as followed from its absorbance at 302 nm, decreases in the presence of hydrogen peroxide, mannitol and ethanol (Alvarez et al., 1995, Chem. Res. Toxicol. 8:859-864; Alvarez et al., 1998, Free Radic. Biol. Med. 24:1331-1337). Recentl...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300411
更新日期:2001-05-01 00:00:00
abstract::Reactive oxygen species (ROS) are involved in the mechanism of photoaging and carcinogenesis. Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. The aim of our study was to estimate the protective effect of manganese against oxidat...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769509065255
更新日期:1995-10-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.715371
更新日期:2012-11-01 00:00:00
abstract::The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up in 1997 to resolve methodological problems and to reach agreement on the basal level of 8-oxo-2'-deoxyguanosine (8-oxodG) in biological samples. In the present ESCODD trial 6 samples of 8-oxodG-containing oligonucleotides with different ratio...
journal_title:Free radical research
pub_type: 杂志文章,多中心研究
doi:10.1080/10715760290029047
更新日期:2002-06-01 00:00:00
abstract::The possible protective effects of resveratrol (RVT) against cardiotoxicity were investigated in Wistar albino rats treated with saline, saline+doxorubicin (DOX; 20 mg/kg) or RVT (10 mg/kg)+DOX. Blood pressure and heart rate were recorded on the 1st week and on the 7th week, while cardiomyopathy was assessed using tra...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760802673008
更新日期:2009-03-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000300601
更新日期:2000-07-01 00:00:00
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journal_title:Free radical research
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doi:10.3109/10715769709097815
更新日期:1997-04-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Free radical research
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doi:10.1080/10611860310001648167
更新日期:2004-03-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001638010
更新日期:2004-05-01 00:00:00
abstract::An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine, and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine, we...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2012.748904
更新日期:2013-02-01 00:00:00
abstract::Oxygen radical generating systems, namely, Cu(II)/ H2O2, Cu(II)/ascorbate, Cu(II)/NAD(P)H, Cu(II)/ H2O2/catecholamine and Cu(II)/H2O2/SH-compounds irreversibly inhibited yeast glutathione reductase (GR) but Cu(II)/H2O2 enhanced the enzyme diaphorase activity. The time course of GR inactivation by Cu(II)/H2O2 dependent...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715769709097858
更新日期:1997-12-01 00:00:00
abstract::Pyruvate is a well-known scavenger of hydrogen peroxide (H2O2). In addition, it scavenges superoxide radical (O2.-). However, evidence on its intracellular antioxidant function is meager at present. Hence, we have examined the effectiveness of this metabolite and its ethyl ester against intracellular oxidative damage ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769809065799
更新日期:1998-02-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715769900301031
更新日期:1999-12-01 00:00:00
abstract::Gamma-glutamylcysteine synthetase (GCS; also referred to as glutamate-cysteine ligase, GLCL) catalyzes the rate-limiting reaction in glutathione (GSH) biosynthesis. The GCS holoenzyme is composed of a catalytic and regulatory subunit, each encoded by a unique gene. In addition to some conditions which specifically upr...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715760000300291
更新日期:2000-04-01 00:00:00
abstract::In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...
journal_title:Free radical research
pub_type: 杂志文章,随机对照试验
doi:10.1080/10715760802555569
更新日期:2008-11-01 00:00:00