Abstract:
:Reactive oxygen species (ROS) are involved in the mechanism of photoaging and carcinogenesis. Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. The aim of our study was to estimate the protective effect of manganese against oxidative injury on cultured human skin fibroblasts. Dithranol, hydrogen peroxide and UV-A radiation (375 nm) were employed as oxidative stressors. The supply of manganese chloride produced an increase in cellular content of this element up to 24 fold without concomitant elevation of MnSOD activity. Nevertheless, manganese protects cells against two of the three ROS generating systems assessed, namely hydrogen peroxyde and UV-A. This protective effect depends on the concentration of manganese in the medium, 0.1 mM and 0.2 mM protect against UVA cytotoxicity, only 0.2 mM protects against H2O2 cytotoxicity.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Parat MO,Richard MJ,Leccia MT,Amblard P,Favier A,Beani JCdoi
10.3109/10715769509065255subject
Has Abstractpub_date
1995-10-01 00:00:00pages
339-51issue
4eissn
1071-5762issn
1029-2470journal_volume
23pub_type
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