Redox balance following magnetic stimulation training in the quadriceps of patients with severe COPD.

Abstract:

:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who underwent quadriceps magnetic stimulation training for 8 weeks. A control group was also studied. In both groups, vastus lateralis specimens were obtained before and after the 8-week period. Muscle protein carbonylation and nitration and antioxidant enzymes were determined using immunoblotting and proportions and sizes of type I and II fibres using immunohistochemistry. Compared to controls, magnetic stimulation muscle training did not modify redox balance, whilst inducing a significant increase in type I fibre sizes. In severe COPD patients, it is concluded that quadriceps magnetic stimulation training was a well-tolerated therapeutic intervention, which did not enhance muscle oxidative stress, while increasing the size of slow-twitch fibres.

journal_name

Free Radic Res

journal_title

Free radical research

authors

Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

doi

10.1080/10715760802555569

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

939-48

issue

11-12

eissn

1071-5762

issn

1029-2470

pii

905979473

journal_volume

42

pub_type

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