Abstract:
:Rheumatoid arthritis (RA) is characterized by synovial proliferation and migration which is induced by proinflammatory cytokines or oxidative stress, followed by joint destruction. Edaravone, clinically available free radical scavenger in Japan, is confirmed to be beneficial in the acute stage of cerebral infarction. We aimed to investigate whether edaravone suppressed in vitro proliferation and migration of synovial cells (SC) induced by IL-1beta. SC proliferation and migration induced by IL-1beta were dose-dependently suppressed by edaravone at the clinically available concentration. These data suggest that edaravone has potential effects to suppress SC proliferation and migration, followed by suppression of synovial proliferation in RA. Therefore, edaravone, an antioxidant agent, might be a novel therapeutic agent which develops the new strategy for treatment of RA, and more detailed studies are required to establish the therapeutic effect of edaravone on RA in vivo.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Arii K,Kumon Y,Ikeda Y,Suehiro T,Hashimoto Kdoi
10.1080/10715760500401116keywords:
subject
Has Abstractpub_date
2006-02-01 00:00:00pages
121-5issue
2eissn
1071-5762issn
1029-2470pii
UX82183081340HP8journal_volume
40pub_type
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