Effect of rhinovirus challenge on antioxidant enzymes in respiratory epithelial cells.

abstract：:Dihydrocalcein (H2-calcein) is recommended as a superior probe for intracellular radical (ROS) detection as different to dichlorodihydrofluorescein (H2-DCF), its oxidation product calcein is thought not to leak out of cells. We determined whether H2-calcein is a useful tool to measure ROS in vascular smooth muscle cel...

journal_title：Free radical research

authors： Keller A,Mohamed A,Dröse S,Brandt U,Fleming I,Brandes RP

更新日期：2004-12-01 00:00:00

abstract：:Hepatic sinusoidal obstruction syndrome (HSOS) is a rare and life-threatening liver disease. (+)-Catechin is a natural dietary flavonol with high antioxidant capacity. This study aims to investigate the involvement of nuclear factor erythroid 2-related factor 2 (Nrf2) antioxidant signalling pathway in the protection o...

journal_title：Free radical research

authors： Jing X,Zhang J,Huang Z,Sheng Y,Ji L

更新日期：2018-04-01 00:00:00

abstract：:5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO), a new cyclic DEPMPO-type nitrone was evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. CYPMPO is colorless crystalline and freely soluble in water. Both the solid and diluted aqueous solution did not dev...

journal_title：Free radical research

authors： Kamibayashi M,Oowada S,Kameda H,Okada T,Inanami O,Ohta S,Ozawa T,Makino K,Kotake Y

更新日期：2006-11-01 00:00:00

abstract：:The purpose of the present study was to investigate the protective effect of esculetin (ES) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the lung epithelial A549 cells. Mice were intragastrically administered with ES (20 and 40 mg/kg) 1 h prior to LPS challenge. ES pretreatment at doses of 20 and 40...

journal_title：Free radical research

authors： Chen T,Guo Q,Wang H,Zhang H,Wang C,Zhang P,Meng S,Li Y,Ji H,Yan T

更新日期：2015-01-01 00:00:00

abstract：:Diabetes mellitus is a risk factor for prognosis after liver resection. In previous work, we found a pro-apoptotic state in the diabetic rat liver. In this work, this was also observed 1 hour post-partial hepatectomy (PH) and resulted in a deficient regenerative response 24 hours post-PH. Treatment with insulin and/or...

journal_title：Free radical research

authors： Francés DE,Ronco MT,Ingaramo PI,Monti JA,Pisani GB,Parody JP,Pellegrino JM,Carrillo MC,Martín-Sanz P,Carnovale CE

更新日期：2011-10-01 00:00:00

abstract：:Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were develop...

journal_title：Free radical research

authors： Earla A,Walter ED,Braslau R

更新日期：2019-12-01 00:00:00

abstract：:A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

journal_title：Free radical research

authors： Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

更新日期：1998-10-01 00:00:00

abstract：:The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up in 1997 to resolve methodological problems and to reach agreement on the basal level of 8-oxo-2'-deoxyguanosine (8-oxodG) in biological samples. In the present ESCODD trial 6 samples of 8-oxodG-containing oligonucleotides with different ratio...

journal_title：Free radical research

authors： Riis B

更新日期：2002-06-01 00:00:00

abstract：:We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene displayed dose-dependent ...

journal_title：Free radical research

authors： Jin YS,Lee MJ,Han W,Heo SI,Sohn SI,Wang MH

更新日期：2006-09-01 00:00:00

abstract：:The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory fac...

journal_title：Free radical research

authors： Lee EK,Kim JM,Choi J,Jung KJ,Kim DH,Chung SW,Ha YM,Yu BP,Chung HY

更新日期：2011-05-01 00:00:00

abstract：:This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...

journal_title：Free radical research

authors： Ionita P

更新日期：2006-01-01 00:00:00

abstract：:Prostaglandin E2 (PGE2) has been reported to play critical roles in cell fate decision by interacting with four types of prostanoid receptors such as EP1, EP2, EP3 and EP4. The present study was aimed at investigating the effect of the EP4-specific agonist CAY10598 in human colon cancer HCT116 cells. Our study reveale...

journal_title：Free radical research

authors： Chae IG,Kim DH,Kundu J,Jeong CH,Kundu JK,Chun KS

更新日期：2014-11-01 00:00:00

abstract：:We investigated whether oxidant status and antioxidant enzyme activities during ageing of mouse brain are regulated in sex-dependent manner. In the homogenate from the brain of 1, 4, 10 and 18 months old male and female CBA mice, lipid peroxidation (LPO), total superoxide dismutase (tSOD), catalase (CAT) and glutathio...

journal_title：Free radical research

authors： Sobocanec S,Balog T,Sverko V,Marotti T

更新日期：2003-07-01 00:00:00

abstract：:APE1/Ref-1, the mammalian ortholog of E. coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has dual role in controlling cellular response to oxidative stress. It is rate-limiting in repair of oxidative DNA damage including strand breaks and also has co-transc...

journal_title：Free radical research

authors： Fantini D,Vascotto C,Deganuto M,Bivi N,Gustincich S,Marcon G,Quadrifoglio F,Damante G,Bhakat KK,Mitra S,Tell G

更新日期：2008-01-01 00:00:00

abstract：:Transforming growth factor-β1 (TGF-β1) induces expression of the proinflammatory and profibrotic cytokine monocyte chemoattractant protein-1 (MCP-1) in tubular epithelial cells (TECs) and thereby contributes to the tubular epithelial-mesenchymal transition (EMT), which in turn leads to the progression of tubulointerst...

journal_title：Free radical research

authors： Li A,Wang J,Zhu D,Zhang X,Pan R,Wang R

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this study was to investigate the absorption and metabolism of hydroxycinnamates from artichoke extract by determining the urinary excretion of the conjugates. Ten healthy, non smoking volunteers (5 female, 5 male) were given three capsules containing artichoke extract every 4 h (0, 4, 8 h) following tw...

journal_title：Free radical research

authors： Rechner AR,Pannala AS,Rice-Evans CA

更新日期：2001-08-01 00:00:00

abstract：:Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein level...

journal_title：Free radical research

authors： Kuo YT,Jheng JH,Lo MC,Chen WL,Wang SG,Lee HM

更新日期：2018-12-01 00:00:00

abstract：:Nitronyl nitroxides (NNs) are the paramagnetic probes that are capable of scavenging physiologically relevant reactive oxygen (ROS) and nitrogen (RNS) species, namely superoxide, nitric oxide (NO), and nitroxyl (HNO). NNs are increasingly considered as potent antioxidants and potential therapeutic agents. Understandin...

journal_title：Free radical research

authors： Bobko AA,Khramtsov VV

更新日期：2015-01-01 00:00:00

abstract：:Approaching living systems, aqueous solutions are appropriate to characterize antioxidants, whereas the frequently used standard 1,1-diphenyl-2-picrylhydrazyl (DPPH) is insoluble in water. Therefore, mixed water-ethanol solvents were investigated using the electron paramagnetic resonance (EPR) spectroscopy. Two forms ...

journal_title：Free radical research

authors： Stasko A,Brezová V,Biskupic S,Misík V

更新日期：2007-04-01 00:00:00

abstract：:Recent research about the role of free radical derivatives of oxygen and nitrogen in biological systems has highlighted the possibility that antioxidants, such as vitamin E, that prevent these processes in vitro may be capable of carrying out a similar function in living organisms in vivo. There is increasing evidence...

journal_title：Free radical research

authors： Diplock AT

更新日期：1997-06-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:Recovery of neurological function in patients following cardiac arrest and cardiopulmonary resuscitation (CPR) is a complex event. Free radical induced oxidative stress is supposed to be involved in this process. We studied levels of 8-iso-PGF2alpha (indicating oxidative injury) and 15-keto-dihydro-PGF2alpha (indicati...

journal_title：Free radical research

authors： Basu S,Liu X,Nozari A,Rubertsson S,Miclescu A,Wiklund L

更新日期：2003-03-01 00:00:00

abstract：:Copper Fenton systems (Cu(II)/H2O2 and Cu(II)/Asc) inactivated the lipoamide reductase and enhanced the diaphorase activity of pig-heart lipoamide dehydrogenase (LADH). Cupric ions alone were less effective. As a result of Cu(II)/H2O2 treatment, the number of titrated thiols in LADH decreased from 6 to 1 per subunit. ...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1995-03-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma (PPARγ) is known to be activated via exercise-associated transient increases in oxidative stress. However, the precise mechanism(s) triggering PPARγ activation in monocytes during/following exercise remain to be confirmed. Here, two cohorts of five healthy male individu...

journal_title：Free radical research

authors： Davies NA,Watkeys L,Butcher L,Potter S,Hughes MG,Moir H,Morris K,Thomas AW,Webb R

更新日期：2015-01-01 00:00:00

abstract：:Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New d...

journal_title：Free radical research

authors： Negre-Salvayre A,Auge N,Ayala V,Basaga H,Boada J,Brenke R,Chapple S,Cohen G,Feher J,Grune T,Lengyel G,Mann GE,Pamplona R,Poli G,Portero-Otin M,Riahi Y,Salvayre R,Sasson S,Serrano J,Shamni O,Siems W,Siow RC,Wis

更新日期：2010-10-01 00:00:00

abstract：:Amphotericin B has been the gold standard for the treatment of invasive mycosis for many years. Its resistance mechanisms are reported to be mainly related to the decrease of ergosterol content or the changes of cell wall. Previous study has shown that Saccharomyces cerevisiae strain lack of BSC2 was sensitive signifi...

journal_title：Free radical research

authors： Kong Y,Wang Q,Cao F,Zhang X,Fang Z,Shi P,Wang H,Shen Y,Huang Z

更新日期：2020-04-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

journal_title：Free radical research

authors： Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

更新日期：2019-12-06 00:00:00

abstract：:The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant defence. Six calves were exposed to 0.75 ppm ozone, 12 h day(-1) for seven consecutive days. Pulmonary function tests...

journal_title：Free radical research

authors： Kirschvink N,Fiévez L,Bureau F,Degand G,Maghuin-Rogister G,Smith N,Art T,Lekeux P

更新日期：2002-01-01 00:00:00

abstract：:The glutathione system in epidermal cells of Allium cepa L. was measured by a quantitative image analysis method, using histochemical staining by monochlorobimane. Blockage of thiol groups with N-ethylmaleimide decreased fluorescence to a small rest fluorescence of maximum 5%. Pre-treatment with dithiothreitol increas...

journal_title：Free radical research

authors： Müller M,Tausz M,Wonisch A,Grill D

更新日期：1999-12-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) levels have been found to be low in human pancreatic cancer [Pancreas 26, (2003), 23] and human pancreatic cancer cell lines [Cancer Res. 63, (2003), 1297] when compared to normal human pancreas. We hypothesized that stable overexpression of pancreatic cancer cells with MnSOD cDN...

journal_title：Free radical research

authors： Ough M,Lewis A,Zhang Y,Hinkhouse MM,Ritchie JM,Oberley LW,Cullen JJ

更新日期：2004-11-01 00:00:00