The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD.

abstract：:The effects of inorganic phosphate (Pi), the main intracellular membrane permeable anion capable of altering mitochondrial pH gradients (Delta pH), were measured on mitochondrial H2O2 release. As expected, Pi decreased Delta pH and increased the electric membrane potential (Delta Psi). Mitochondrial H2O2 release was s...

journal_title：Free radical research

authors： Oliveira GA,Kowaltowski AJ

更新日期：2004-10-01 00:00:00

abstract：:The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this ...

journal_title：Free radical research

authors： Tartaro Bujak I,Mihaljević B,Ferreri C,Chatgilialoglu C

更新日期：2016-11-01 00:00:00

abstract：:The production of reactive oxygen species, including hydrogen peroxide (H(2)O(2)), is increased in diseased blood vessels. Although H(2)O(2) leads to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP signaling pathway, it is not clear whether this reactive molecule affects the redox state of sGC...

journal_title：Free radical research

authors： Tawa M,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2015-01-01 00:00:00

abstract：:Adriamycin (ADR) is nephrotoxic. One component of ADR-induced nephropathy may be oxidative stress. This study used a recently developed line of transgenic mice (Nmt) on the FVB background strain, which over-express the antioxidant protein metallothionein (MT) in podocytes. Cultured podocytes from Nmt mice were resista...

journal_title：Free radical research

authors： Yang L,Zheng S,Epstein PN

更新日期：2009-02-01 00:00:00

abstract：:Oxidative stress appears to be implicated in the pathogenesis of various diseases including hepatotoxicity. Although intracellular Ca2+ signals have been suggested to play a role in the oxidative damage of hepatocytes, the sources and effects of oxidant-induced intracellular Ca2+ increases are currently debatable. Thu...

journal_title：Free radical research

authors： Kim JA,Kang YS,Lee SH,Lee YS

更新日期：2000-09-01 00:00:00

abstract：:The review deals with impairment of Ca(2+)-ATPases by high glucose or its derivatives in vitro, as well as in human diabetes and experimental animal models. Acute increases in glucose level strongly correlate with oxidative stress. Dysfunction of Ca(2+)-ATPases in diabetic and in some cases even in nondiabetic conditi...

journal_title：Free radical research

authors： Horáková L,Strosova MK,Spickett CM,Blaskovic D

更新日期：2013-08-01 00:00:00

abstract：:Autophagy modulation is a potential therapeutic strategy for breast cancer, and a previous study indicated that metformin exhibits significant anti-carcinogenic activity. However, the ability of metformin to induce autophagy and its role in breast cancer cell death remains unclear. In this study, we exposed MCF-7 cell...

journal_title：Free radical research

authors： Tan M,Wu A,Liao N,Liu M,Guo Q,Yi J,Wang T,Huang Y,Qiu B,Zhou W

更新日期：2018-08-01 00:00:00

abstract：:A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by the tert-butylhydroperoxide/PbO2 system. The ...

journal_title：Free radical research

authors： Tanfani F,Carloni P,Damiani E,Greci L,Wozniak M,Kulawiak D,Jankowski K,Kaczor J,Matuszkiewics A

更新日期：1994-10-01 00:00:00

abstract：:In cells, NADH and NADPH are mainly bound to dehydrogenases such as lactate dehydrogenase (LDH). In cell-free systems, the binary LDH-NADH complex has been demonstrated to produce reactive oxygen species via a chain oxidation of NADH initiated and propagated by superoxide. We studied here whether this chain radical re...

journal_title：Free radical research

authors： Petrat F,Bramey T,Kirsch M,De Groot H

更新日期：2005-10-01 00:00:00

abstract：:The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up in 1997 to resolve methodological problems and to reach agreement on the basal level of 8-oxo-2'-deoxyguanosine (8-oxodG) in biological samples. In the present ESCODD trial 6 samples of 8-oxodG-containing oligonucleotides with different ratio...

journal_title：Free radical research

authors： Riis B

更新日期：2002-06-01 00:00:00

abstract：:Tumour necrosis factor alpha (TNF alpha) cytotoxicity is mediated, at least in part, by oxidative stress and phospholipase A2 activation. The first post-receptor events to be observed in TNF alpha-sensitive lines are the generation of superoxide anion (O2-) within the mitochondria and the activation of phospholipase A...

journal_title：Free radical research

authors： Polla BS,Jacquier-Sarlin MR,Kantengwa S,Mariéthoz E,Hennet T,Russo-Marie F,Cossarizza A

更新日期：1996-08-01 00:00:00

abstract：:Creatol (CTL) is a product resulting from the reaction of creatinine (Cr) with the hydroxyl radical and is identified as a precursor of methylguanidine (MG), a uremic toxin. In this study, we investigated serum CTL levels together with those of Cr and MG in 66 patients who were on maintenance hemodialysis (HD). Prior ...

journal_title：Free radical research

authors： Tomida C,Aoyagi K,Nagase S,Gotoh M,Yamagata K,Takemura K,Koyama A

更新日期：2000-01-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) is a neurotoxin to produce an animal model of Parkinson's disease. 6-OHDA increased the formation of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), a biomarker of oxidatively damaged DNA, and induced apoptosis in human neuroblastoma SH-SY5Y cells. Iron or copper chelators inhibited 6-OHDA-i...

journal_title：Free radical research

authors： Kobayashi H,Oikawa S,Umemura S,Hirosawa I,Kawanishi S

更新日期：2008-07-01 00:00:00

abstract：:The reduction of ferrate(VI) to ferrate(V) by superoxide ions was studied over the pH range 2.6-13.0 using the premix pulse radiolysis technique. The pH dependence indicates that only the unstable protonated forms of ferrate, H2FeO4 (pKa3.5) and HFeO4- (pKa7.3) are reactive, k(HFeO4(-) + O2) = (1.7 +/- 0.2) x 10(7) M-...

journal_title：Free radical research

authors： Rush JD,Zhao Z,Bielski BH

更新日期：1996-03-01 00:00:00

abstract：:Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo. The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/m...

journal_title：Free radical research

authors： Gieseg SP,Reibnegger G,Wachter H,Esterbauer H

更新日期：1995-08-01 00:00:00

abstract：INTRODUCTION:Nuclear factor, erythroid 2 like 2 (NFE2L2) is an important transcription factor that protects cells from oxidative stress (OS). NFE2L2 deficiency in placentas is associated with pregnancy complications. We have demonstrated that elevated OS existed in placental shares of the smaller fetus in selective int...

journal_title：Free radical research

authors： Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

更新日期：2017-04-01 00:00:00

abstract：:Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from ...

journal_title：Free radical research

authors： Wei YP,Jia CN,Lan Y,Hou XQ,Zuo JJ,Cui H,Guan XJ,Wang Y,Mao GY

更新日期：2019-04-01 00:00:00

abstract：:Free radical oxidation of cholesterol and its precursors contribute significantly to the pathophysiology of a number of human diseases. This review intends to summarize recent developments and provide a perspective on the reactivities of sterols toward free radical oxidation, the free radical reaction mechanism, and t...

journal_title：Free radical research

authors： Xu L,Porter NA

更新日期：2015-01-01 00:00:00

abstract：:The present study was designed to determine whether hydroxymethylglutaryl-CoA reductase inhibitors (statins) modulate the NO production via iNOS in adipocytes stimulated by lipopolysaccharide (L) and tumour necrosis factor-alpha (T). Well-differentiated 3T3-L1 adipocytes significantly produced NO by LT-treatment. Pre-...

journal_title：Free radical research

authors： Araki S,Dobashi K,Asayama K,Shirahata A

更新日期：2007-09-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their h...

journal_title：Free radical research

authors： Chen X,Zhong Z,Xu Z,Chen L,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress. Two groups of Sprague Dawley rats were used: one vehicle-exposed group undergoing inhalation of NaCl (0.9%, n = 24) and one Cd-exposed group unde...

journal_title：Free radical research

authors： Kirschvink N,Martin N,Fievez L,Smith N,Marlin D,Gustin P

更新日期：2006-03-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is characterised by excessive accumulation of hepatic lipids and oxidative injury of hepatocytes. Scutellarin is a flavonoid glycoside having antioxidative stress activity. Our current study aims to investigate the molecular mechanism of scutellarin ameliorating NAFLD. Scutella...

journal_title：Free radical research

authors： Zhang X,Ji R,Sun H,Peng J,Ma X,Wang C,Fu Y,Bao L,Jin Y

更新日期：2018-02-01 00:00:00

abstract：:N-nitroso species have recently been detected in animal tissues. Protein N-nitrosotryptophan is the best candidate for this N-nitroso pool. N-nitrosation of N-blocked trytophan derivatives like melatonin (MelH) by N2O3 or peroxynitrite (ONOOH/ONOO- ) has been observed under conditions of pH and reagent concentrations ...

journal_title：Free radical research

authors： Peyrot F,Houée-Levin C,Ducrocq C

更新日期：2006-09-01 00:00:00

abstract：:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...

journal_title：Free radical research

authors： Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

更新日期：2008-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS co...

journal_title：Free radical research

authors： Sheshadri P,Kumar A

更新日期：2016-01-01 00:00:00

abstract：:Over the last decades, oxidative stress has been described as a deleterious phenomenon contributing to numerous noncommunicable diseases such as cardiovascular disease, diabetes, and cancers. As many authors ascribed the healthy effect of fruit and vegetable consumption mainly to their antioxidant contents, it has bee...

journal_title：Free radical research

authors： Courraud J,Charnay C,Cristol JP,Berger J,Avallone S

更新日期：2013-12-01 00:00:00

abstract：:Silibinin, a major active constituent of silymarin, is clinically used as a hepatoprotectant, and in recent years, it has been used for the treatment of cancer in China. Because the mechanism of silibinin action on cancer cells was still unclear, we investigated the contribution of silibinin to the induction of apopto...

journal_title：Free radical research

authors： Yu Y,Fan SM,Yuan SJ,Tashiro S,Onodera S,Ikejima T

更新日期：2012-11-01 00:00:00

abstract：:We investigated whether oxidant status and antioxidant enzyme activities during ageing of mouse brain are regulated in sex-dependent manner. In the homogenate from the brain of 1, 4, 10 and 18 months old male and female CBA mice, lipid peroxidation (LPO), total superoxide dismutase (tSOD), catalase (CAT) and glutathio...

journal_title：Free radical research

authors： Sobocanec S,Balog T,Sverko V,Marotti T

更新日期：2003-07-01 00:00:00

abstract：:G72 has been characterised as a susceptibility gene that can have wide-ranging effects in a number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is a potential serum biomarker for schizophrenia. Previous transcriptomic and biochemical studies have indicated th...

journal_title：Free radical research

authors： Wang M,Saw HP,Cui FF,Lin SY,Chang HT,Chiu CD

更新日期：2018-09-01 00:00:00

abstract：:Membrane rafts (MRs) are specialized microdomains in the cell membrane with an altered lipid composition. Upon various stimulations, MRs can be clustered to aggregate or recruit NADPH oxidase sub-units and related proteins to form MR redox signalosomes in the membrane of cells like vascular endothelial cells (ECs). Mu...

journal_title：Free radical research

authors： Zhang C,Li PL

更新日期：2010-08-01 00:00:00