Abstract:
:The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory factors with oxidative damage and showed inactivation of FOXO and its target genes, catalase and SOD. However, baicalein suppressed radiation-induced inflammatory response by negatively regulating NF-κB and up-regulating FOXO activation and catalase and SOD activities. Furthermore, baicalein inhibited radiation-induced phosphorylation of MAPKs and Akt, which are the upstream kinases of NF-κB and FOXOs. Based on these findings, it is concluded that baicalein has a radioprotective effect against NF-κB-mediated inflammatory response through MAPKs and the Akt pathway, which is accompanied by the protective effects on FOXO and its target genes, catalase and SOD. Thus, these findings provide new insights into the molecular mechanism underlying the radioprotective role of baicalein in mice.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Lee EK,Kim JM,Choi J,Jung KJ,Kim DH,Chung SW,Ha YM,Yu BP,Chung HYdoi
10.3109/10715762.2011.555479subject
Has Abstractpub_date
2011-05-01 00:00:00pages
507-17issue
5eissn
1071-5762issn
1029-2470journal_volume
45pub_type
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