Scavenging of benzylperoxyl radicals by carotenoids.

abstract：:To determine effect of nitric oxide (NO) on cellular glutathione peroxidase (GPX) level in living cells, we measured the activity, protein and mRNA of GPX in rat kidney (KNRK) cells under a high NO condition. Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ...

journal_title：Free radical research

authors： Dobashi K,Asayama K,Nakane T,Kodera K,Hayashibe H,Nakazawa S

更新日期：2001-09-01 00:00:00

abstract：:Ribonucleotide reductases catalyze the irreversible reductive formation of 2'-deoxyribonucleotides required for DNA replication and cell proliferation, and a radical mechanism was assumed to be involved in this reaction. In order to search for a radical in the aerobic manganese ribonucleotide reductase (Mn-RRase) by e...

journal_title：Free radical research

authors： Griepenburg U,Lassmann G,Auling G

更新日期：1996-06-01 00:00:00

abstract：:Gastric inflammation is a highly complex biochemical protective response to cellular/tissue injury. When this process occurs in an uncontrolled manner, the result is excessive cellular/tissue damage that results chronic inflammation and destruction of normal tissue. Current evidence suggests that Helicobacter pylori (...

journal_title：Free radical research

authors： Yoshikawa T,Naito Y

更新日期：2000-12-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress. Two groups of Sprague Dawley rats were used: one vehicle-exposed group undergoing inhalation of NaCl (0.9%, n = 24) and one Cd-exposed group unde...

journal_title：Free radical research

authors： Kirschvink N,Martin N,Fievez L,Smith N,Marlin D,Gustin P

更新日期：2006-03-01 00:00:00

abstract：PURPOSE:Ionizing radiation generates free radicals and reactive oxygen species that induce DNA damage in vivo. This study aimed to determine the relationship between serum reactive oxygen metabolite (ROM) levels and skin reaction after irradiation in a rat model. METHODS AND MATERIALS:I. Female Wistar rats were classi...

journal_title：Free radical research

authors： Nomiya T,Kaneko T,Goto J,Harada M,Akamatsu H,Hagiwara Y,Ota I,Nemoto K

更新日期：2014-05-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their h...

journal_title：Free radical research

authors： Chen X,Zhong Z,Xu Z,Chen L,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:Membrane rafts (MRs) are specialized microdomains in the cell membrane with an altered lipid composition. Upon various stimulations, MRs can be clustered to aggregate or recruit NADPH oxidase sub-units and related proteins to form MR redox signalosomes in the membrane of cells like vascular endothelial cells (ECs). Mu...

journal_title：Free radical research

authors： Zhang C,Li PL

更新日期：2010-08-01 00:00:00

abstract：:The production of reactive oxygen species, including hydrogen peroxide (H(2)O(2)), is increased in diseased blood vessels. Although H(2)O(2) leads to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP signaling pathway, it is not clear whether this reactive molecule affects the redox state of sGC...

journal_title：Free radical research

authors： Tawa M,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2015-01-01 00:00:00

abstract：:Penicillins, as bactericidal antibiotics, have been widely used to treat infections for several decades. Their structure contains both aromatic and thioether moieties susceptible to free radical oxidation. The (•)OH induced oxidation mechanism of amoxicillin was investigated by pulse radiolysis techniques and by final...

journal_title：Free radical research

authors： Szabó L,Tóth T,Rácz G,Takács E,Wojnárovits L

更新日期：2016-01-01 00:00:00

abstract：:Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the stu...

journal_title：Free radical research

authors： Salvioli S,Olivieri F,Marchegiani F,Cardelli M,Santoro A,Bellavista E,Mishto M,Invidia L,Capri M,Valensin S,Sevini F,Cevenini E,Celani L,Lescai F,Gonos E,Caruso C,Paolisso G,De Benedictis G,Monti D,Franceschi C

更新日期：2006-12-01 00:00:00

abstract：:Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). I...

journal_title：Free radical research

authors： Chokchaiwong S,Kuo YT,Lin SH,Hsu YC,Hsu SP,Liu YT,Chou AJ,Kao SH

更新日期：2018-12-01 00:00:00

abstract：:Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

journal_title：Free radical research

authors： Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

更新日期：2010-09-01 00:00:00

abstract：:In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose to...

journal_title：Free radical research

authors： Venditti P,Reed TT,Victor VM,Di Meo S

更新日期：2019-03-01 00:00:00

abstract：:The oxidative stress possibly resulting from an inherited respiratory chain (RC) deficiency was investigated in a series of human cultured skin fibroblasts presenting either ubiquinone depletion or isolated defect of the various RC complexes. Taken as an index for superoxide overproduction, a significant induction of ...

journal_title：Free radical research

authors： Geromel V,Rötig A,Munnich A,Rustin P

更新日期：2002-04-01 00:00:00

abstract：:The response of HeLa cells to subcellular spatially localized two-photon irradiation of a singlet oxygen photosensitizer (protoporphyrin IX, PpIX) using a focused laser was assessed. Upon irradiation under these conditions, a localized population of PpIX excited states can be produced with meaningful intracellular spa...

journal_title：Free radical research

authors： Gollmer A,Besostri F,Breitenbach T,Ogilby PR

更新日期：2013-09-01 00:00:00

abstract：:The toxic effect of copper was evaluated in sunflower plants by means of root elongation, lipid peroxidation and antioxidative enzyme activities. Plants were grown under controlled environmental conditions in hydroponic culture for two weeks and exposed to different copper concentrations for an additional week. Determ...

journal_title：Free radical research

authors： García A,Baquedano FJ,Navarro P,Castillo FJ

更新日期：1999-12-01 00:00:00

abstract：:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by meas...

journal_title：Free radical research

authors： Rathee JS,Patro BS,Brown L,Chattopadhyay S

更新日期：2016-01-01 00:00:00

abstract：:Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitm...

journal_title：Free radical research

authors： Rossi M,Delbauve S,Roumeguère T,Wespes E,Leo O,Flamand V,Le Moine A,Hougardy JM

更新日期：2019-10-01 00:00:00

abstract：:We evaluated whether nutritional vitamin A deficiency generates oxidative stress and inflammation in aorta. Wistar male rats (21 days old) were given free access to a control (8 mg retinol as retinyl palmitate/kg) or a vitamin A- deficient diet for three months. One group of deficient animals was fed with the control ...

journal_title：Free radical research

authors： Gatica L,Alvarez S,Gomez N,Zago MP,Oteiza P,Oliveros L,Gimenez MS

更新日期：2005-06-01 00:00:00

abstract：:Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin extracted from several Cortinarius mushrooms among them C. orellanus. The pathogenic mechanism involved in the C. orellanus-poisoning by orellanine leading to kidney impairment is not yet fully understood until now. Electron spin resonance (ESR) sp...

journal_title：Free radical research

authors： Oubrahim H,Richard JM,Cantin-Esnault D

更新日期：1998-05-01 00:00:00

abstract：:Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

journal_title：Free radical research

authors： Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

更新日期：2009-03-01 00:00:00

abstract：:Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice...

journal_title：Free radical research

authors： Kang ES,Lee J,Homma T,Kurahashi T,Kobayashi S,Nabeshima A,Yamada S,Seo HG,Miyata S,Sato H,Fujii J

更新日期：2017-01-01 00:00:00

abstract：:Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...

journal_title：Free radical research

authors： Hiramoto K,Tomiyama S,Kikugawa K

更新日期：1999-01-01 00:00:00

abstract：:The production of microRNAs (miRNA) is influenced by various stimuli, including environmental stresses. We hypothesized that reactive oxygen species (ROS)-associated stress could regulate macrophage miRNA synthesis. miRNAs undergo unique steps of maturation processing through either one of two pathways of cytoplasmic ...

journal_title：Free radical research

authors： Ranjan R,Lee YG,Karpurapu M,Syed MA,Chung S,Deng J,Jeong JJ,Zhao G,Xiao L,Sadikot RT,Weiss MJ,Christman JW,Park GY

更新日期：2015-01-01 00:00:00

abstract：:The beneficial effects of hyperoxia have been noted in treatment of several diseases and pathological states. However, the excessive production of ROS under hyperoxic conditions can directly damage cellular macromolecules if the imbalance in antioxidant status exists. Cytochrome P450 (Cyp) 4a14 has an important role i...

journal_title：Free radical research

authors： Sobocanec S,Balog T,Sarić A,Sverko V,Zarković N,Gasparović AC,Zarković K,Waeg G,Macak-Safranko Z,Kusić B,Marotti T

更新日期：2010-02-01 00:00:00

abstract：:Effects of vitamins B, C, E, K and P, as well as coenzymes Q, on formation of final products of radiation-induced free-radical transformations of ethanol, ethylene glycol, alpha-methylglycoside and glucose in aqueous solutions were studied. Based on the obtained results, it can be concluded that there are substances a...

journal_title：Free radical research

authors： Shadyro OI,Sosnovskaya AA,Edimecheva IP,Grintsevich IB,Lagutin PY,Alekseev AV,Kazem K

更新日期：2005-07-01 00:00:00

abstract：:Cardiolipin (CL) is a mitochondria-specific phospholipid and is critical for maintaining the integrity of mitochondrial membrane and mitochondrial function. CL also plays an active role in mitochondria-dependent apoptosis by interacting with cytochrome c (cyt c), tBid and other important Bcl-2 proteins. The unique str...

journal_title：Free radical research

authors： Yin H,Zhu M

更新日期：2012-08-01 00:00:00

abstract：:In a prospective, double-blind, randomised placebo-controlled study, we tested the hypothesis that a new formulation consisting of wheat gliadin chemically combined with a vegetal (thus orally effective) preparation of superoxide dismutase (SOD) allows to prevent hyperbaric oxygen (HBO)-induced oxidative cell stress. ...

journal_title：Free radical research

authors： Muth CM,Glenz Y,Klaus M,Radermacher P,Speit G,Leverve X

更新日期：2004-09-01 00:00:00

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00

abstract：:Oxidative stress is associated with many cardiovascular diseases, such as hypertension and arteriosclerosis. Oxidative stress reportedly activates the L-type voltage-gated calcium channel (VDCCL) and elevates [Ca2+]i in many cells. However, how oxidative stress activates VDCCL under clinical setting and the consequenc...

journal_title：Free radical research

authors： Park HJ,Shin KC,Yoou SK,Kang M,Kim JG,Sung DJ,Yu W,Lee Y,Kim SH,Bae YM,Park SW

更新日期：2019-01-01 00:00:00