Scavenging of benzylperoxyl radicals by carotenoids.


:Carotenoids scavenge simple lipid-like alkylperoxyl radicals. However, the rate constant is too low to be determined directly and the mechanism is likewise not known with certainty [Mortensen, A. and Skibsted, L.H. (1998) FEBS Lett. 426, 392-396]. It is demonstrated that carotenoids react with peroxyl radicals only slightly more reactive than lipidperoxyl radicals neither by electron transfer nor by hydrogen atom donation, but by adduct formation. Benzylperoxyl radicals are scavenged by the carotenoids beta-carotene and canthaxanthin with a second-order rate constant of at least 1 x 10(6) M(-1) s(-1) by formation of an adduct which decays in a first-order reaction.


Free Radic Res


Free radical research


Mortensen A





Has Abstract


2002-02-01 00:00:00












  • Nucleoside transporters are critical to the uptake and antioxidant activity of 7,8-dihydroneopterin in monocytic cells.

    abstract::7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms. Therefore, the objective of this study was to...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Janmale TV,Lindsay A,Gieseg SP

    更新日期:2020-05-01 00:00:00

  • Mth1 deficiency provides longer survival upon intraperitoneal crocidolite injection in female mice.

    abstract::Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Funahashi S,Okazaki Y,Akatsuka S,Takahashi T,Sakumi K,Nakabeppu Y,Toyokuni S

    更新日期:2020-03-01 00:00:00

  • Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase.

    abstract::Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. The aim of this study...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Madsen-Bouterse SA,Zhong Q,Mohammad G,Ho YS,Kowluru RA

    更新日期:2010-03-01 00:00:00

  • Aldehyde adducts generated during lipid peroxidation modification of proteins.

    abstract::Various lines of evidence indicate that an important part in the pathogenesis of atherosclerosis is the modification of the plasma low-density lipoproteins (LDLs). A large number of pro-inflammatory and pro-atherogenic properties have been ascribed to the oxidatively modified LDLs and their components. There is consid...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Uchida K

    更新日期:2015-01-01 00:00:00

  • Antioxidant effects and hepatoprotective activity of 2,5-dihydroxy-4,3'-di(beta-d-glucopyranosyloxy)-trans-stilbene from Morus bombycis Koidzumi roots on CCl4-induced liver damage.

    abstract::We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene displayed dose-dependent ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Jin YS,Lee MJ,Han W,Heo SI,Sohn SI,Wang MH

    更新日期:2006-09-01 00:00:00

  • Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease.

    abstract::Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer's, Parkinson's and prion diseases and their respective animal models. While the causes of oxidative stress are relatively well-documented, the effects of chronically reducing oxidative stress on cognition, patholo...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Siedlak SL,Casadesus G,Webber KM,Pappolla MA,Atwood CS,Smith MA,Perry G

    更新日期:2009-02-01 00:00:00

  • Prevention of intracellular oxidative stress to lens by pyruvate and its ester.

    abstract::Pyruvate is a well-known scavenger of hydrogen peroxide (H2O2). In addition, it scavenges superoxide radical (O2.-). However, evidence on its intracellular antioxidant function is meager at present. Hence, we have examined the effectiveness of this metabolite and its ethyl ester against intracellular oxidative damage ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Varma SD,Devamanoharan PS,Ali AH

    更新日期:1998-02-01 00:00:00

  • The heme oxygenase pathway and its interaction with nitric oxide in the control of cellular homeostasis.

    abstract::Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO), iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is susceptible to up-regulation by a diverse variety of conditions and agents in mammalian tissue, leading to the common conception that HO-1 is a s...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Foresti R,Motterlini R

    更新日期:1999-12-01 00:00:00

  • Do mitochondria make nitric oxide? no?

    abstract::Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

    更新日期:2004-06-01 00:00:00

  • Silver nanoparticles-induced H2O2 triggers apoptosis-like death and is associated with dinF in Escherichia coli.

    abstract::Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Kim S,Lee DG

    更新日期:2021-01-06 00:00:00

  • Interactions of malondialdehyde and 4-hydroxynonenal with rat liver plasma membranes and their effect on binding of prostaglandin E2 by specific receptors.

    abstract::We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Buko VU,Artsukevich A,Zavodnik I,Maltsev A,Sushko L,Zimmermann T,Dianzani MU

    更新日期:1996-11-01 00:00:00

  • Oxidative stress, d-ROMs test, and ceruloplasmin.

    abstract::Human serum samples were evaluated for oxidative stress with the d-ROMs test. The ceruloplasmin (CP) and copper contents of the samples was independently measured and compared to those calculated on the basis of the d-ROMs test results for pure CP solutions. The d-ROMs readings did not show any significant correlation...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Colombini F,Carratelli M,Alberti A

    更新日期:2016-01-01 00:00:00

  • Does manganese protect cultured human skin fibroblasts against oxidative injury by UVA, dithranol and hydrogen peroxide?

    abstract::Reactive oxygen species (ROS) are involved in the mechanism of photoaging and carcinogenesis. Skin is endowed with antioxidant enzymes including superoxide dismutases (SOD): cytosolic copper zinc SOD and mitochondrial manganese SOD. The aim of our study was to estimate the protective effect of manganese against oxidat...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Parat MO,Richard MJ,Leccia MT,Amblard P,Favier A,Beani JC

    更新日期:1995-10-01 00:00:00

  • Antioxidant properties of catechins and proanthocyanidins: effect of polymerisation, galloylation and glycosylation.

    abstract::A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

    更新日期:1998-10-01 00:00:00

  • Exercise training and oxidative stress in the elderly as measured by antipyrine hydroxylation products.

    abstract::Effects of 12 wk exercise training on oxidative stress were examined in elderly humans. We measured oxidative stress during a 45 min cycling test by using antipyrine hydroxylation products. Antipyrine breakdown is independent of blood flow to the liver, which is important during exercise. Furthermore, antipyrine react...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Meijer EP,Coolen SA,Bast A,Westerterp KR

    更新日期:2001-10-01 00:00:00

  • Plasma protein carbonyls in nonpregnant, healthy pregnant and preeclamptic women.

    abstract::Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Zusterzeel PL,Mulder TP,Peters WH,Wiseman SA,Steegers EA

    更新日期:2000-11-01 00:00:00

  • GSK-3β inhibition by curcumin mitigates amyloidogenesis via TFEB activation and anti-oxidative activity in human neuroblastoma cells.

    abstract::The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

    更新日期:2020-07-28 00:00:00

  • Analysis of dichlorodihydrofluorescein and dihydrocalcein as probes for the detection of intracellular reactive oxygen species.

    abstract::Dihydrocalcein (H2-calcein) is recommended as a superior probe for intracellular radical (ROS) detection as different to dichlorodihydrofluorescein (H2-DCF), its oxidation product calcein is thought not to leak out of cells. We determined whether H2-calcein is a useful tool to measure ROS in vascular smooth muscle cel...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Keller A,Mohamed A,Dröse S,Brandt U,Fleming I,Brandes RP

    更新日期:2004-12-01 00:00:00

  • Turning point in apoptosis/necrosis induced by hydrogen peroxide.

    abstract::The turning point between apoptosis and necrosis induced by hydrogen peroxide (H2O2) have been investigated using human T-lymphoma Jurkat cells. Cells treated with 50 microM H2O2 exhibited caspase-9 and caspase-3 activation, finally leading to apoptotic cell death. Treatment with 500 microM H2O2 did not exhibit caspas...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Saito Y,Nishio K,Ogawa Y,Kimata J,Kinumi T,Yoshida Y,Noguchi N,Niki E

    更新日期:2006-06-01 00:00:00

  • AGEs, contributors to placental bed vascular changes leading to preeclampsia.

    abstract::Glycation of proteins or other biomolecules and their further long-term degradation result in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction trigg...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Guedes-Martins L,Matos L,Soares A,Silva E,Almeida H

    更新日期:2013-08-01 00:00:00

  • Novel polyhydroxylated fullerene suppresses intracellular oxidative stress together with repression of intracellular lipid accumulation during the differentiation of OP9 preadipocytes into adipocytes.

    abstract::Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

    更新日期:2010-09-01 00:00:00

  • Visualising reactive oxygen species in live mammals and revealing of ROS-related system.

    abstract::Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Li

    更新日期:2019-12-01 00:00:00

  • Hispidulin: antioxidant properties and effect on mitochondrial energy metabolism.

    abstract::Hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3',4'-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant and antineoplastic properties, although their action mechanisms have not been previously described. We now report the eff...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Dabaghi-Barbosa P,Mariante Rocha A,Franco da Cruz Lima A,Heleno de Oliveira B,Benigna Martinelli de Oliveira M,Gunilla Skare Carnieri E,Cadena SM,Eliane Merlin Rocha M

    更新日期:2005-12-01 00:00:00

  • Status of antioxidants in brain microvessels of monkey and rat.

    abstract::Levels of certain antioxidants namely reduced glutathione (GSH), ascorbic acid (Vit C), alpha-tocopherol (Vit E) and antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR) were compared in monkey and rat brain microvessels which constitute the blood...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Shukla A,Dikshit M,Srimal RC

    更新日期:1995-04-01 00:00:00

  • Salicylate trapping of .OH as a tool for studying post-ischemic oxidative injury in the isolated rat heart.

    abstract::The use of salicylate as a chemical trap for .OH represents a simple and convenient alternative to the use of spin trapping techniques to study oxidative injury in isolated perfused organs. In these systems, salicylate is included in the perfusion buffer at concentrations ranging from 0.1 to 2 mM depending on the dete...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Powell SR

    更新日期:1994-11-01 00:00:00

  • Lipid peroxidation, tissue necrosis, and metabolic and mechanical recovery of isolated reperfused rat heart as a function of increasing ischemia.

    abstract::Isolated Langendorff-perfused rat hearts, after 30 min of preperfusion, were submitted to increasing times of global normothermic ischemia (1, 2, 5, 10, 20 and 30 min) or to the same times of ischemia followed by 30 min of reperfusion. Analysis of malondialdehyde, ascorbic acid, oxypurines, nucleosides, nicotinic coen...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Tavazzi B,Di Pierro D,Bartolini M,Marino M,Distefano S,Galvano M,Villani C,Giardina B,Lazzarino G

    更新日期:1998-01-01 00:00:00

  • Peroxyl radical scavenging activities of hamamelitannin in chemical and biological systems.

    abstract::The antioxidative activities of hamamelitannin (2',5-di-O-galloyl-hamamelose), gallic acid and dl-alpha-tocopherol against lipid peroxyl radicals were evaluated in chemical and biological systems. The peroxyl radical scavenging activity was evaluated by electron spin resonance (ESR) method in which both spin-trapping ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Masaki H,Atsumi T,Sakurai H

    更新日期:1995-05-01 00:00:00

  • Free radical oxidation of cholesterol and its precursors: Implications in cholesterol biosynthesis disorders.

    abstract::Free radical oxidation of cholesterol and its precursors contribute significantly to the pathophysiology of a number of human diseases. This review intends to summarize recent developments and provide a perspective on the reactivities of sterols toward free radical oxidation, the free radical reaction mechanism, and t...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Xu L,Porter NA

    更新日期:2015-01-01 00:00:00

  • An investigation of the antioxidant activity of black tea using enhanced chemiluminescence.

    abstract::Antioxidants are important species which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. A variety of free radical-scavenging antioxidants exist within the body many of which are derived from dietary sources. There is currently much interest in the antioxidant role ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Robinson EE,Maxwell SR,Thorpe GH

    更新日期:1997-03-01 00:00:00

  • Oxidative aggregation of ceruloplasmin induced by hydrogen peroxide is prevented by pyruvate.

    abstract::Ceruloplasmin (CP) is a blue copper glycoprotein with multiple physiological functions including ferroxidase and oxidase activities. CP is also an important serum oxygen free radical (OFR) scavenger and antioxidant, exerting cardioprotective and antifibrillatory actions. Although it has been reported that CP activitie...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Aouffen M,Paquin J,Furtos A,Waldron KC,Mateescu MA

    更新日期:2004-01-01 00:00:00