Abstract:
:The synproportionation reaction between ferryl leghemoglobin and oxyleghemoglobin does not occur, at least under conditions where this process could be clearly demonstrated with myoglobin and hemoglobin. In contrast, a cross synproportionation can occur between oxyleghemoglobin and ferryl myoglobin or between ferryl leghemoglobin and oxymyoglobin. The non-exposure, at the surface of the leghemoglobin molecule, of the nearest tyrosine residue to the heme group could explain this behaviour. Thus leghemoglobin per se does not appear to be able to act as an antioxidant in removing H2O2 by synproportionation. However, in the presence of ascorbate and/or glutathione which can reduce ferryl leghemoglobin, this hemoprotein could act as an H2O2-removing antioxidant, in a process similar to that described for myoglobin. This could also explain why, despite the absence of synproportionation, ferryl leghemoglobin is not detected in nodule extracts.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Mathieu C,Swaraj K,Davies MJ,Trinchant JC,Puppo Adoi
10.3109/10715769709097848subject
Has Abstractpub_date
1997-08-01 00:00:00pages
165-71issue
2eissn
1071-5762issn
1029-2470journal_volume
27pub_type
杂志文章abstract::Ascorbic acid (vitamin C) induced hydrogen peroxide (H(2)O(2)) formation was measured in household drinking water and metal supplemented Milli-Q water by using the FOX assay. Here we show that ascorbic acid readily induces H(2)O(2) formation in Cu(II) supplemented Milli-Q water and poorly buffered household drinking w...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500249861
更新日期:2005-11-01 00:00:00
abstract::Neopterin and the reduced form, 7,8-dihydroneopterin (78NP) are pteridines released from macrophages when stimulated with gamma-interferon in vivo. The role of 78NP in inflammatory response is unknown though neopterin has been used clinically as a marker of immune cell activation, due to its very fluorescent nature. U...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300121
更新日期:2001-02-01 00:00:00
abstract::We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609149064
更新日期:1996-11-01 00:00:00
abstract::Cholesterol is an essential component of mammalian plasma membrane. Alterations in sterol metabolism or oxidation have been linked to various pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Unsaturated sterols are vulnerable to oxidation induced by singlet oxygen an...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2021.1879387
更新日期:2021-01-26 00:00:00
abstract::Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1364377
更新日期:2017-07-01 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) induces Mv1Lu cell senescence through inactivating glycogen synthase kinase 3 (GSK3), thereby inactivating complex IV and increasing intracellular ROS. In the present study, we identified protein kinase C delta (PKCδ) as an upstream regulator of GSK3 inactivation in this mechanis...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.929120
更新日期:2014-09-01 00:00:00
abstract::Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1418982
更新日期:2018-01-01 00:00:00
abstract::Oxidative stress may initiate lipid peroxidation that generates ethane. Ethane, at low concentrations, is eliminated by pulmonary exhalation. Previous methods have not allowed frequent sampling, thus ethane kinetics has not been studied in man. A validated method over the range 3.8-100,000 ppb with a limit of quantita...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576031000107353
更新日期:2003-08-01 00:00:00
abstract::The use of salicylate as a chemical trap for .OH represents a simple and convenient alternative to the use of spin trapping techniques to study oxidative injury in isolated perfused organs. In these systems, salicylate is included in the perfusion buffer at concentrations ranging from 0.1 to 2 mM depending on the dete...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715769409056588
更新日期:1994-11-01 00:00:00
abstract::p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to ce...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2013.821200
更新日期:2013-11-01 00:00:00
abstract::The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769509064017
更新日期:1995-07-01 00:00:00
abstract::Myeoloperoxidase catalyses the formation of hypochlorous acid (HOCl) via reaction of H(2)O(2) with Cl(-) ion. Although HOCl is known to play a major role in the human immune system by killing bacteria and other invading pathogens, excessive generation of this oxidant is known to cause damage to tissue. Recently, it wa...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760802098834
更新日期:2008-05-01 00:00:00
abstract::Septic shock, a severe form of sepsis, is characterized by cardiovascular collapse following microbial invasion of the body. The progressive hypotension, hyporeactivity to vasopressor agents and vascular leak leads to circulatory failure with multiple organ dysfunction and death. Many inflammatory mediators (e.g. TNF-...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760410001725517
更新日期:2004-11-01 00:00:00
abstract::Silibinin, a major active constituent of silymarin, is clinically used as a hepatoprotectant, and in recent years, it has been used for the treatment of cancer in China. Because the mechanism of silibinin action on cancer cells was still unclear, we investigated the contribution of silibinin to the induction of apopto...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.715369
更新日期:2012-11-01 00:00:00
abstract::A glycomic approach to the identification of target molecules in glycosyltransferase gene targeting mice is a promising strategy to understand the biological significance of glycosyltransferase genes in vivo. In order to understand the biological effects of N-acetylglucosaminyltransferase III (GnT-III) on tumor format...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576021000005258
更新日期:2002-08-01 00:00:00
abstract::Nine male volunteers were given 36 g of cocoa powder (containing 2610 mg of polyphenols) per day with sugar and 6 volunteers received an equivalent amount of sugar for 2 weeks. Conjugated diene production in LDL induced by 2-2' azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) and copper ion were evaluated. The lag t...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300091
更新日期:2001-01-01 00:00:00
abstract::Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currentl...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1353688
更新日期:2017-06-01 00:00:00
abstract::The protecting ability of the Piper betle leaves-derived phenol, allylpyrocatechol (APC) against AAPH-induced membrane damage of human red blood cells (RBCs) was investigated. Compared to control, AAPH (50 mM) treatment resulted in significant hemolysis (55%, p < 0.01), associated with increased malondialdehyde (MDA) ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2013.816847
更新日期:2013-09-01 00:00:00
abstract::Sonodynamic therapy, a promising new approach to cancer treatment, is based on synergistic cell killing by combination of certain drugs (sonosensitizers) and ultrasound. Although the mechanism of sonodynamic action is not understood, the role of free radicals produced from sonosensitizers by ultrasound is implicated. ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609145652
更新日期:1996-07-01 00:00:00
abstract::Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300621
更新日期:2001-07-01 00:00:00
abstract::Individuals with low serum cholesterol experience greater than expected age-adjusted mortality from non-atherosclerotic diseases, including cancer, respiratory and digestive illnesses, but the basis for these associations remains unclear. The current investigation considered the hypothesis that hypocholesterolemia is ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609149049
更新日期:1996-09-01 00:00:00
abstract::Interactions between transition metal ions and polyphenols can result in complexation, redox or polymerization, but the relative importance of these reactions is unclear. The present paper reports results from the reaction of gallic acid (GA) with Cu(II) using electron paramagnetic resonance (EPR) and UV/visible spect...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2010.515220
更新日期:2011-02-01 00:00:00
abstract::After minimal sample preparation, two different HPLC methodologies, one based on a single gradient reversed-phase HPLC step, the other on multiple HPLC runs each optimised for specific components, were used to investigate the composition of flavonoids and phenolic acids in apple and tomato juices. The principal compon...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000300551
更新日期:2000-06-01 00:00:00
abstract::It is well known that reperfusion damage of ischemic myocardium may be attributed to alterations in the antioxidant defense system against free radical aggression. In addition, the degree of myocardial damage may depend on the duration and severity of ischemia that precedes reperfusion. We carried out serial ischemic ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769409147514
更新日期:1994-03-01 00:00:00
abstract::Subjecting selected peptides to in vitro analyses covering their ability to interfere with the lipid oxidation chain reaction as well as to protect proteins from direct and indirect oxidation has provided the basis for a more detailed understanding of peptide-mediated protection in biological systems. The efficiency o...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760903137101
更新日期:2009-10-01 00:00:00
abstract::The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300411
更新日期:1999-05-01 00:00:00
abstract::In order to elucidate the oxidative damage in rat brain caused by oxidative stress, regional changes in the levels of lipid peroxidation products and antioxidative defense systems in cerebral cortex and hippocampus, and in their synapses, which modulate learning and memory functions in the brain, were studied. When ra...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576031000090019
更新日期:2003-04-01 00:00:00
abstract::The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by ge...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576031000061020
更新日期:2003-03-01 00:00:00
abstract::The NADPH oxidase (NOX) family of enzymes oxidase catalyzes the transport of electrons from NADPH to molecular oxygen and generates O(2)(•-), which is rapidly converted into H(2)O(2). We aimed to identify in hepatocytes the protein NOX complex responsible for H(2)O(2) synthesis after α(1)-adrenoceptor (α(1)-AR) stimul...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.627920
更新日期:2011-11-01 00:00:00
abstract::The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidat...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1542141
更新日期:2019-02-01 00:00:00