Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease.

abstract：:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by meas...

journal_title：Free radical research

authors： Rathee JS,Patro BS,Brown L,Chattopadhyay S

更新日期：2016-01-01 00:00:00

abstract：:The intracellular superoxide and glutathione disulphide concentrations increased in Penicillium chrysogeum treated with 50, 250 or 500 microM menadione (MQ). A significant increase in the intracellular peroxide concentration was also observed when mycelia were exposed to 250 or 500 microM MQ. The specific activity of ...

journal_title：Free radical research

authors： Emri T,Pócsi I,Szentirmai A

更新日期：1999-02-01 00:00:00

abstract：BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...

journal_title：Free radical research

authors： Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue M

更新日期：2004-04-01 00:00:00

abstract：:We investigated the antioxidant and radical scavenging activity of polyphenolic isochromans. To assess the relation between structure and scavenging properties the natural occurring 1-(3'-methoxy-4'-hydroxy)phenyl-6,7-dihydroxy-isochroman (ISO-3, three OH groups) was compared with three newly synthesized derivatives t...

journal_title：Free radical research

authors： Lorenz P,Zeh M,Martens-Lobenhoffer J,Schmidt H,Wolf G,Horn TF

更新日期：2005-05-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress. Two groups of Sprague Dawley rats were used: one vehicle-exposed group undergoing inhalation of NaCl (0.9%, n = 24) and one Cd-exposed group unde...

journal_title：Free radical research

authors： Kirschvink N,Martin N,Fievez L,Smith N,Marlin D,Gustin P

更新日期：2006-03-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...

journal_title：Free radical research

authors： Kim S,Lee DG

更新日期：2021-01-06 00:00:00

abstract：:Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...

journal_title：Free radical research

authors： Zhang H,Zheng RL

更新日期：1996-04-01 00:00:00

abstract：:We have determined the effects of chronic vitamin C intake on neutrophil and lymphocyte antioxidant defences during the acute phase immune response induced by intense exercise. Blood samples were taken from 16 voluntary athletes in basal conditions, both immediately after and 1 h after a duathlon competition. Sportsme...

journal_title：Free radical research

authors： Tauler P,Aguiló A,Gimeno I,Noguera A,Agustí A,Tur JA,Pons A

更新日期：2003-09-01 00:00:00

abstract：:Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice...

journal_title：Free radical research

authors： Kang ES,Lee J,Homma T,Kurahashi T,Kobayashi S,Nabeshima A,Yamada S,Seo HG,Miyata S,Sato H,Fujii J

更新日期：2017-01-01 00:00:00

abstract：:The antioxidant properties of protoporphyrin IX and related tetrapyrroles are poorly characterized. Therefore, eight tetrapyrroles, five of which are produced in vivo, were tested to assess their antioxidant capacities in the Salmonella reverse mutation, TEAC, FRAP and ORAC assays. Tertiary-butyl hydroperoxide (tert-B...

journal_title：Free radical research

authors： Mölzer C,Huber H,Steyrer A,Ziesel G,Ertl A,Plavotic A,Wallner M,Bulmer AC,Wagner KH

更新日期：2012-11-01 00:00:00

abstract：:A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

journal_title：Free radical research

authors： Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

更新日期：1998-10-01 00:00:00

abstract：:Paraquat is a synthetic bipyridylium salt widely used as herbicide and defoliant. Enzyme-catalyzed redoxcycling of paraquat generates oxygen radicals. The toxic, even lethal, effects of paraquat are due to free radical-mediated tissue injury. Ocular lesions, sometimes quite severe, have been observed following acciden...

journal_title：Free radical research

authors： Nordquist RE,Nguyen H,Poyer JL,Carubelli R

更新日期：1995-07-01 00:00:00

abstract：:Glucose at pathophysiological concentrations was able to accelerate copper-induced oxidation of isolated low-density lipoprotein (LDL) and whole serum. The efficiency of glucose was favored under the following circumstances: (a) when LDL oxidation was induced by low copper concentration, (b) when LDL was partly oxidiz...

journal_title：Free radical research

authors： Leoni V,Albertini R,Passi A,Abuja PM,Borroni P,D'Eril GM,De Luca G

更新日期：2002-05-01 00:00:00

abstract：:We investigated whether oxidant status and antioxidant enzyme activities during ageing of mouse brain are regulated in sex-dependent manner. In the homogenate from the brain of 1, 4, 10 and 18 months old male and female CBA mice, lipid peroxidation (LPO), total superoxide dismutase (tSOD), catalase (CAT) and glutathio...

journal_title：Free radical research

authors： Sobocanec S,Balog T,Sverko V,Marotti T

更新日期：2003-07-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:Validation of markers requires two different steps. The first one is the analytical validation including analytical procedures, definition of standard reference, and round-tests analysis. The second one is the assessment of the biological relevance of the selected marker. This biological relevance may be in the field ...

journal_title：Free radical research

authors： Antoine JM,Diplock AT

更新日期：2000-11-01 00:00:00

abstract：:Nerve growth factor (NGF) is one of the several structurally related proteins, named neurotrophins (NTs), that regulate neuronal survival, development, function, and plasticity. Moreover, NGF is an important activator of antioxidant mechanisms. These NGF functions are mediated by tropomyosin-related kinase receptor A ...

journal_title：Free radical research

authors： Valdovinos-Flores C,Gonsebatt ME

更新日期：2013-05-01 00:00:00

abstract：:The significance of 5-lipoxygenase and myeloperoxidase activities has not been extensively studied among young male smokers. Leukotriene B(4), 20-hydroxy-leukotriene B(4), 20-carboxy-leukotriene B(4) and 3-chlorotyrosine were measured in plasma and urinary samples of young male smokers at 8 hours following cigarette a...

journal_title：Free radical research

authors： Loke WM,Lam KM,Chong WL,Chew SE,Quek AM,Lim ECh,Seet RC

更新日期：2012-10-01 00:00:00

abstract：:We have reported previously that the apparent rate of peroxynitrite (ONOO(-) ) decay, as followed from its absorbance at 302 nm, decreases in the presence of hydrogen peroxide, mannitol and ethanol (Alvarez et al., 1995, Chem. Res. Toxicol. 8:859-864; Alvarez et al., 1998, Free Radic. Biol. Med. 24:1331-1337). Recentl...

journal_title：Free radical research

authors： Alvarez B,Radi R

更新日期：2001-05-01 00:00:00

abstract：:The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or doubl...

journal_title：Free radical research

authors： Rytter E,Johansson C,Vessby B,Sjödin A,Möller L,Akesson B,Basu S

更新日期：2010-05-01 00:00:00

abstract：:The aim of the study was to analyse the effect of Val 16Ala polymorphism in SOD2 gene on oxidative stress parameters and lipid profile of the blood during a three-month wrestling training. The study included 53 Polish young wrestlers. Blood samples were collected at the beginning of the programme and following three m...

journal_title：Free radical research

authors： Jówko E,Gierczuk D,Cieśliński I,Kotowska J

更新日期：2017-05-01 00:00:00

abstract：:Mammalian odorant-binding proteins (OBPs) are soluble lipocalins produced in the nasal mucosa and in other epithelial tissues of several animal species, where they are supposed to serve as scavengers for small structurally unrelated hydrophobic molecules. These would include odorants and toxic aldehydes like 4-hydroxy...

journal_title：Free radical research

authors： Macedo-Márquez A,Vázquez-Acevedo M,Ongay-Larios L,Miranda-Astudillo H,Hernández-Muñoz R,González-Halphen D,Grolli S,Ramoni R

更新日期：2014-07-01 00:00:00

abstract：:There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation of the amyloid proteins associated with some of these diseases. Hydrog...

journal_title：Free radical research

authors： Tabner BJ,Turnbull S,King JE,Benson FE,El-Agnaf OM,Allsop D

更新日期：2006-07-01 00:00:00

abstract：:Asthma is an allergic inflammation driven by the Th2 immune response with release of cytokines such as IL-4 and IL-13, which contribute to the airflow limitations and airway hyperresponsiveness (AHR). The involvement of oxidative stress in this process is well-established, but the specific role of the superoxide anion...

journal_title：Free radical research

authors： Nesi RT,Barroso MV,Souza Muniz V,de Arantes AC,Martins MA,Brito Gitirana L,Neves JS,Benjamim CF,Lanzetti M,Valenca SS

更新日期：2017-07-01 00:00:00

abstract：:Ascorbic acid (vitamin C) induced hydrogen peroxide (H(2)O(2)) formation was measured in household drinking water and metal supplemented Milli-Q water by using the FOX assay. Here we show that ascorbic acid readily induces H(2)O(2) formation in Cu(II) supplemented Milli-Q water and poorly buffered household drinking w...

journal_title：Free radical research

authors： Jansson PJ,Lindqvist C,Nordström T

更新日期：2005-11-01 00:00:00

abstract：:An involvement of oxidative stress (OS) was found in recent studies of Sjøgren's syndrome (SS) that reported significant changes in protein oxidation, myeloperoxidase activity, TNF-α, nitrotyrosine, and GSH levels in plasma from SS patients. Excess levels of OS markers, as oxidative DNA damage and propanoyl-lysine, we...

journal_title：Free radical research

authors： Pagano G,Castello G,Pallardó FV

更新日期：2013-02-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:It is well known that antioxidants such as AA (reduced ascorbate), glutathione (GSH) (reduced glutathione) and melatonin can delay seed ageing. Can they recover aged seed? Artificial aged maize seeds were obtained and their reduced germination rate (GR) and high lipid peroxidation were recorded. Exogenous melatonin wa...

journal_title：Free radical research

authors： Deng B,Yang K,Zhang Y,Li Z

更新日期：2017-10-01 00:00:00

abstract：:The aim of the study was to investigate whether there is transmembrane transport of intact glutathione ([3H]-GSH, 0.1 microCi) in rat and human type II pneumocytes (T2P), and if this transport might be dependent on the redox state of the extracellular fluid. The T2P were pretreated with acivicin (250 microM) to inhibi...

journal_title：Free radical research

authors： van Klaveren RJ,Hoet PH,Demedts M,Nemery B

更新日期：1999-05-01 00:00:00

abstract：:Parkinson's disease (PD) is a neurodegenerative disorder characterised by selective degeneration of the nigral dopaminergic neurons, and neuroinflammation and oxidative stress are believed to be involved in its pathogenesis. In the present study, we provide data that the synthetic steroid exemestane, which is currentl...

journal_title：Free radical research

authors： Son HJ,Han SH,Lee JA,Shin EJ,Hwang O

更新日期：2017-06-01 00:00:00