Can antioxidant's reactive oxygen species (ROS) scavenging capacity contribute to aged seed recovery? Contrasting effect of melatonin, ascorbate and glutathione on germination ability of aged maize seeds.

abstract：:The widely used anti-cancer drug cisplatin imparts various toxic manifestations in the host, with nephrotoxicity being the most severe one. The trace element selenium shows antioxidant activity in both human and animals. The present study was designed to assess the chemoprotecting and chemoenhancing efficacy of a naph...

journal_title：Free radical research

authors： Ghosh P,Singha Roy S,Basu A,Bhattacharjee A,Bhattacharya S

更新日期：2015-04-01 00:00:00

abstract：:Flavonoids, which are dietary components and have possible drug uses, inhibit lipoprotein oxidation in vitro. The present study considered whether flavonoid supplementation in humans could influence lipoprotein vulnerability to oxidation. Citrus flavonoid supplementation (about 1g/day, 3 weeks), or placebo, was given ...

journal_title：Free radical research

authors： Blostein-Fujii A,DiSilvestro RA,Frid D,Katz C

更新日期：1999-04-01 00:00:00

abstract：:Paraquat is a synthetic bipyridylium salt widely used as herbicide and defoliant. Enzyme-catalyzed redoxcycling of paraquat generates oxygen radicals. The toxic, even lethal, effects of paraquat are due to free radical-mediated tissue injury. Ocular lesions, sometimes quite severe, have been observed following acciden...

journal_title：Free radical research

authors： Nordquist RE,Nguyen H,Poyer JL,Carubelli R

更新日期：1995-07-01 00:00:00

abstract：:Nerve growth factor (NGF) is one of the several structurally related proteins, named neurotrophins (NTs), that regulate neuronal survival, development, function, and plasticity. Moreover, NGF is an important activator of antioxidant mechanisms. These NGF functions are mediated by tropomyosin-related kinase receptor A ...

journal_title：Free radical research

authors： Valdovinos-Flores C,Gonsebatt ME

更新日期：2013-05-01 00:00:00

abstract：:Autophagy modulation is a potential therapeutic strategy for breast cancer, and a previous study indicated that metformin exhibits significant anti-carcinogenic activity. However, the ability of metformin to induce autophagy and its role in breast cancer cell death remains unclear. In this study, we exposed MCF-7 cell...

journal_title：Free radical research

authors： Tan M,Wu A,Liao N,Liu M,Guo Q,Yi J,Wang T,Huang Y,Qiu B,Zhou W

更新日期：2018-08-01 00:00:00

abstract：:During the early postimplantation period, rodent embryos survive in a relatively anaerobic environment in utero and are vulnerable to a high oxygen pressure. They become resistant to oxygen stress when they are exposed to a higher oxygen pressure after the uteroplacental circulation is established. However, it is unkn...

journal_title：Free radical research

authors： Kobayashi-Miura M,Nakamura H,Yodoi J,Shiota K

更新日期：2002-09-01 00:00:00

abstract：:In cells, NADH and NADPH are mainly bound to dehydrogenases such as lactate dehydrogenase (LDH). In cell-free systems, the binary LDH-NADH complex has been demonstrated to produce reactive oxygen species via a chain oxidation of NADH initiated and propagated by superoxide. We studied here whether this chain radical re...

journal_title：Free radical research

authors： Petrat F,Bramey T,Kirsch M,De Groot H

更新日期：2005-10-01 00:00:00

abstract：:Along with differentiation of mouse stromal preadipocytes OP9 into adipocytes, intracellular ROS, especially superoxide anion radicals detected by NBT reduction assay, were found to appreciably increase, mainly in cytoplasmic area, parallelling with increases in intracellular lipid-droplet accumulation, whereas undiff...

journal_title：Free radical research

authors： Saitoh Y,Xiao L,Mizuno H,Kato S,Aoshima H,Taira H,Kokubo K,Miwa N

更新日期：2010-09-01 00:00:00

abstract：:To examine the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) in the oxidative stress-induced increase of permeability in endothelial cells, the effects of a p38 MAPK inhibitor (SB203580) and ERK inhibitor (PD90859) on the H2O2-induced increase of permeab...

journal_title：Free radical research

authors： Niwa K,Inanami O,Ohta T,Ito S,Karino T,Kuwabara M

更新日期：2001-11-01 00:00:00

abstract：:We have determined the effects of chronic vitamin C intake on neutrophil and lymphocyte antioxidant defences during the acute phase immune response induced by intense exercise. Blood samples were taken from 16 voluntary athletes in basal conditions, both immediately after and 1 h after a duathlon competition. Sportsme...

journal_title：Free radical research

authors： Tauler P,Aguiló A,Gimeno I,Noguera A,Agustí A,Tur JA,Pons A

更新日期：2003-09-01 00:00:00

abstract：:C-phycocyanins, major biliproteins of blue green algae (cyanobacteria), widely used as colourants in food and cosmetics are known for their antioxidant as well as therapeutic potential. Recent claims indicating phycobiliproteins exert stronger photodynamic action on tumor cells than clinically approved hematoporphyrin...

journal_title：Free radical research

authors： Paul BT,Patel A,Selvam GS,Mishra S,Ghosh PK,Murugesan R

更新日期：2006-08-01 00:00:00

abstract：:Myeoloperoxidase catalyses the formation of hypochlorous acid (HOCl) via reaction of H(2)O(2) with Cl(-) ion. Although HOCl is known to play a major role in the human immune system by killing bacteria and other invading pathogens, excessive generation of this oxidant is known to cause damage to tissue. Recently, it wa...

journal_title：Free radical research

authors： Park SY,Lee SM,Shin SW,Park JW

更新日期：2008-05-01 00:00:00

abstract：:Oxidative stress appears to be implicated in the pathogenesis of various diseases including hepatotoxicity. Although intracellular Ca2+ signals have been suggested to play a role in the oxidative damage of hepatocytes, the sources and effects of oxidant-induced intracellular Ca2+ increases are currently debatable. Thu...

journal_title：Free radical research

authors： Kim JA,Kang YS,Lee SH,Lee YS

更新日期：2000-09-01 00:00:00

abstract：:We have investigated the toxicity to human monocytemacrophages, and susceptibility to oxidation, of different individual dietary fatty acids in cholesterol esters and triglycerides, added to the cell cultures as coacervates with bovine serum albumin. Toxicity was assessed using release of radioactivity from cells prel...

journal_title：Free radical research

authors： Hardwick SJ,Carpenter KL,Law NS,Van Der Veen C,Marchant CE,Hird R,Mitchinson MJ

更新日期：1997-04-01 00:00:00

abstract：:Ionizing radiations such as X-ray and γ-ray can directly or indirectly produce clustered or multiple damages in DNA. Previous studies have reported that overexpression of DNA glycosylases in Escherichia coli (E. coli) and human lymphoblast cells caused increased sensitivity to γ-ray and X-ray irradiation. However, the...

journal_title：Free radical research

authors： Yoshikawa Y,Yamasaki A,Takatori K,Suzuki M,Kobayashi J,Takao M,Zhang-Akiyama QM

更新日期：2015-10-01 00:00:00

abstract：:8-Oxoguanine (8-oxoG) is the most common DNA base modification in the mammalian genome, associated with oxidative stress. Here we analysed the alterations in the distribution of 8-oxoG across the entire murine genome, before and after an elevation of oxidative stress by the use of ferric nitrilotriacetate (Fe-NTA) as ...

journal_title：Free radical research

authors： Akatsuka S,Li GH,Kawaguchi S,Takahashi T,Yoshihara M,Suyama M,Toyokuni S

更新日期：2020-04-16 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

journal_title：Free radical research

authors： Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

更新日期：2019-12-06 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:An iodoacetamide azaadamantyl spin label was studied in fluid solution and in 9:1 trehalose:sucrose glass. In 9:1 toluene:CH2Cl2 solution at 293 K, the isotropic nitrogen hyperfine coupling is 19.2 G, T1 is 0.37 µs and T2 is 0.30-0.35 µs. Between about 80 and 150 K 1/Tm in 9:1 trehalose:sucrose is approximately indepe...

journal_title：Free radical research

authors： Eaton SS,Rajca A,Yang Z,Eaton GR

更新日期：2018-03-01 00:00:00

abstract：:Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...

journal_title：Free radical research

authors： Zusterzeel PL,Mulder TP,Peters WH,Wiseman SA,Steegers EA

更新日期：2000-11-01 00:00:00

abstract：:The synproportionation reaction between ferryl leghemoglobin and oxyleghemoglobin does not occur, at least under conditions where this process could be clearly demonstrated with myoglobin and hemoglobin. In contrast, a cross synproportionation can occur between oxyleghemoglobin and ferryl myoglobin or between ferryl l...

journal_title：Free radical research

authors： Mathieu C,Swaraj K,Davies MJ,Trinchant JC,Puppo A

更新日期：1997-08-01 00:00:00

abstract：:We tested the hypothesis that hypertension associated with polycythemia vera (PV) may be related to hemoglobin released from erythrocytes (cell-free hemoglobin, fHb). We assessed hematocrit, mean arterial pressure (MAP), blood viscosity, and the level of fHb and nitrite/nitrate (NOx) in the plasma of 73 PV patients an...

journal_title：Free radical research

authors： Rusak T,Misztal T,Piszcz J,Tomasiak M

更新日期：2014-02-01 00:00:00

abstract：:Flavonoids are components of fruit and vegetables that may be beneficial in the prevention of disease such as cancer and cardiovascular diseases. Their beneficial effects will be dependent upon their uptake and disposition in tissues and cells. The metabolism and pharmacokinetics of flavonoids has been an area of acti...

journal_title：Free radical research

authors： Manach C,Donovan JL

更新日期：2004-08-01 00:00:00

abstract：:Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...

journal_title：Free radical research

authors： Peerapanyasut W,Thamprasert K,Wongmekiat O

更新日期：2014-02-01 00:00:00

abstract：:In the present study we isolated proteasome complexes from control, mild cognitive impairment (MCI), and Alzheimer's disease (AD) subjects. No significant difference in the amount of proteasomes was detected across the different groups, although impairments in chymotrypsin-like proteasome activity was observed in AD s...

journal_title：Free radical research

authors： Cecarini V,Ding Q,Keller JN

更新日期：2007-06-01 00:00:00

abstract：:Weaning mice were fed a diet supplemented with beef tallow (BT) or BT plus docosahexaenoic acid (DHA) containing 100 mg alpha-tocopherol/kg (alpha-Toc100) or 500 mg alpha-tocopherol/kg (alpha-Toc500) for 4 wk to modify membrane fatty acid unsaturation, and then were administered ferric nitrilotriacetate (Fe-NTA). The ...

journal_title：Free radical research

authors： Yasuda S,Watanabe S,Kobayashi T,Hata N,Misawa Y,Utsumi H,Okuyama H

更新日期：1999-03-01 00:00:00

abstract：:Glycation of proteins or other biomolecules and their further long-term degradation result in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction trigg...

journal_title：Free radical research

authors： Guedes-Martins L,Matos L,Soares A,Silva E,Almeida H

更新日期：2013-08-01 00:00:00

abstract：:Ceruloplasmin (CP) is a blue copper glycoprotein with multiple physiological functions including ferroxidase and oxidase activities. CP is also an important serum oxygen free radical (OFR) scavenger and antioxidant, exerting cardioprotective and antifibrillatory actions. Although it has been reported that CP activitie...

journal_title：Free radical research

authors： Aouffen M,Paquin J,Furtos A,Waldron KC,Mateescu MA

更新日期：2004-01-01 00:00:00

abstract：:Anxiety disorders are the most common mental illness in the USA affecting 18% of the population. The cause(s) of anxiety disorders is/are not completely clear, and research in the neurobiology of anxiety at the molecular level is still rather limited. Although mounting clinical and preclinical evidence now indicates t...

journal_title：Free radical research

authors： Fedoce ADG,Ferreira F,Bota RG,Bonet-Costa V,Sun PY,Davies KJA

更新日期：2018-07-01 00:00:00

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00