Abstract:
:Weaning mice were fed a diet supplemented with beef tallow (BT) or BT plus docosahexaenoic acid (DHA) containing 100 mg alpha-tocopherol/kg (alpha-Toc100) or 500 mg alpha-tocopherol/kg (alpha-Toc500) for 4 wk to modify membrane fatty acid unsaturation, and then were administered ferric nitrilotriacetate (Fe-NTA). The mortality caused by Fe-NTA was higher in the group fed the DHA (alpha-Toc100) diet than in the BT diet groups but the DHA (alpha-Toc500) diet suppressed this increase. Serum and kidney alpha-tocopherol contents were slightly influenced by the dietary fatty acids but not significantly. These results indicate that the increased unsaturation of tissue lipids enhances oxidative damage induced by Fe-NTA in mice fed DHA (alpha-Toc100) but not when additional alpha-tocopherol is supplemented. The apparent discrepancy between the observed enhancement by dietary DHA of oxidative damage and the beneficial effects of dietary DHA on the so-called free radical diseases is discussed in terms of strong bolus oxidative stress and moderate chronic oxidative stress.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Yasuda S,Watanabe S,Kobayashi T,Hata N,Misawa Y,Utsumi H,Okuyama Hdoi
10.1080/10715769900300221keywords:
subject
Has Abstractpub_date
1999-03-01 00:00:00pages
199-205issue
3eissn
1071-5762issn
1029-2470journal_volume
30pub_type
杂志文章abstract::Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...
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journal_title:Free radical research
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doi:10.3109/10715762.2014.995183
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abstract::Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...
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doi:10.3109/10715762.2014.974037
更新日期:2015-01-01 00:00:00
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journal_title:Free radical research
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doi:10.3109/10715762.2015.1136063
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journal_title:Free radical research
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doi:10.1080/10715762.2018.1437914
更新日期:2018-04-01 00:00:00
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doi:10.3109/10715762.2011.579120
更新日期:2011-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1994-03-01 00:00:00
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journal_title:Free radical research
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更新日期:2012-03-01 00:00:00
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journal_title:Free radical research
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pub_type: 杂志文章,随机对照试验
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更新日期:2012-10-01 00:00:00
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更新日期:2011-04-01 00:00:00