Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats.


:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by measuring the systolic BP (SBP). DOCA-salt rats showed very high SBP, associated with organ hypertrophy, collagen depositions, and inflammatory infiltrations in cardiac and aortic sections, reduced plasma total antioxidant status and NO level, and increased levels of TBARS, PGI2 as well as vasoconstrictors (AVP, Big ET, and ET-1). DOCA-salt also reduced smooth muscle- and endothelium-dependent vascular relaxation in rats. Mal C reversed all these changes of the DOCA-salt rats and improved their vascular reactivity. Mal C exerts anti-hypertensive property in DOCA-salt rats by reducing oxidative stress and organ hypertrophy, and improving endothelial and vascular functions. Given that mal C has appreciable natural abundance and is non-toxic to rodents, further studies would help in establishing its medicinal potential against hypertension.


Free Radic Res


Free radical research


Rathee JS,Patro BS,Brown L,Chattopadhyay S




Has Abstract


2016-01-01 00:00:00












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    abstract::Cigarette smoking is associated with increased oxidative stress and increased risk of degenerative disease. As the major lipophilic antioxidant, requirements for vitamin E may be higher in smokers due to increased utilisation. In this observational study we have compared vitamin E status in smokers and non-smokers usi...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Jeanes YM,Hall WL,Proteggente AR,Lodge JK

    更新日期:2004-08-01 00:00:00

  • Activated oxygen generation from thylakoids: a novel spin trap.

    abstract::Using a novel phosphorylated spin trap, 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO), an analogue of the commonly used spin trap 5,5'-dimethyl-1-pyrroline N-oxide (DMPO), we have investigated the production of oxygen radical species under illumination of thylakoids from wheat (Triticum durum Desf cv. O...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Sgherri CL,Pinzino C,Samaritani E,Navari-Izzo F

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    abstract::A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

    更新日期:2008-03-01 00:00:00

  • Spatially resolved two-photon irradiation of an intracellular singlet oxygen photosensitizer: correlating cell response to the site of localized irradiation.

    abstract::The response of HeLa cells to subcellular spatially localized two-photon irradiation of a singlet oxygen photosensitizer (protoporphyrin IX, PpIX) using a focused laser was assessed. Upon irradiation under these conditions, a localized population of PpIX excited states can be produced with meaningful intracellular spa...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Gollmer A,Besostri F,Breitenbach T,Ogilby PR

    更新日期:2013-09-01 00:00:00

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    abstract::The purpose of the present study was to investigate the protective effect of esculetin (ES) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the lung epithelial A549 cells. Mice were intragastrically administered with ES (20 and 40 mg/kg) 1 h prior to LPS challenge. ES pretreatment at doses of 20 and 40...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Chen T,Guo Q,Wang H,Zhang H,Wang C,Zhang P,Meng S,Li Y,Ji H,Yan T

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Wang H,Jenner AM,Lee CY,Shui G,Tang SY,Whiteman M,Wenk MR,Halliwell B

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  • Pharmacology, genomics, and the evolutionary biology of ageing.

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    journal_title:Free radical research

    pub_type: 杂志文章,评审


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    更新日期:2002-12-01 00:00:00

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Parat MO,Richard MJ,Leccia MT,Amblard P,Favier A,Beani JC

    更新日期:1995-10-01 00:00:00

  • Free radical production after exposure of astrocytes and astrocytic C6 glioma cells to ethanol. Preliminary results.

    abstract::Formation of the alpha-hydroxyethyl radical (CH3 degree CHOH) has already been extensively demonstrated after ethanol metabolism in the liver. Despite favourable conditions, this formation in the brain has remained speculative since there is no direct experimental evidence in intact brain cells. In this preliminary st...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Gonthier B,Eysseric H,Soubeyran A,Daveloose D,Saxod R,Barret L

    更新日期:1997-12-01 00:00:00

  • The potential of lipid-polymer nanoparticles as epigenetic and ROS control approaches for COPD.

    abstract::Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

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    authors: Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

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  • Azaadamantyl nitroxide spin label: complexation with β-cyclodextrin and electron spin relaxation.

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Eaton SS,Rajca A,Yang Z,Eaton GR

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  • Podophyllotoxin and rutin in combination prevents oxidative stress mediated cell death and advances revival of mice gastrointestine following lethal radiation injury.

    abstract::Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Dutta A,Gupta ML,Verma S

    更新日期:2018-01-01 00:00:00

  • Posttranslational protein modifications by reactive nitrogen and chlorine species and strategies for their prevention and elimination.

    abstract::Proteins are subject to various posttranslational modifications, some of them being undesired from the point of view of metabolic efficiency. Prevention of such modifications is expected to provide new means of therapy of diseases and decelerate the process of aging. In this review, modifications of proteins by reacti...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Sadowska-Bartosz I,Ott C,Grune T,Bartosz G

    更新日期:2014-11-01 00:00:00

  • Vitamin C (ascorbic acid) induced hydroxyl radical formation in copper contaminated household drinking water: role of bicarbonate concentration.

    abstract::We have previously shown that Vitamin C (ascorbic acid) can trigger hydroxyl radical formation in copper contaminated household drinking water. We report here that the capacity of ascorbic acid to catalyze hydroxyl radical generation in the drinking water samples is strongly dependent on the bicarbonate concentration ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Jansson PJ,Asplund KU,Mäkelä JC,Lindqvist C,Nordström T

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Berg K,Wiseth R,Bjerve K,Brurok H,Gunnes S,Skarra S,Jynge P,Basu S

    更新日期:2004-05-01 00:00:00

  • Validation of markers for their relevance to health and disease.

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    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Antoine JM,Diplock AT

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    abstract::Nitration-induced protein damage in the placenta leads to impaired blood flow and deficient feto-placental exchange in diabetic pregnancies. This work studied the effect of nitric oxide and peroxynitrite on Cu/Zn SOD activity in rat placentas and evaluated whether Cu/Zn SOD is nitrated in the placenta from diabetic ra...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: White V,Capobianco E,Higa R,Martínez N,Sosa M,Pustovrh MC,Jawerbaum A

    更新日期:2010-12-01 00:00:00

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

    更新日期:2009-03-01 00:00:00

  • Measurement of oxidatively induced DNA damage and its repair, by mass spectrometric techniques.

    abstract::Oxidatively induced damage caused by free radicals and other DNA-damaging agents generate a plethora of products in the DNA of living organisms. There is mounting evidence for the involvement of this type of damage in the etiology of numerous diseases including carcinogenesis. For a thorough understanding of the mecha...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Dizdaroglu M,Coskun E,Jaruga P

    更新日期:2015-05-01 00:00:00

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    abstract::Liver microsomal functions related to xenobiotic biotransformation and free radical production were studied in control rats and in animals subjected to L-3,3',5-triiodothyronine (T3) and/or lindane administration as possible mechanisms contributing to oxidative stress, in relation to the activity of enzymes (superoxid...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Simon Giavarotti KA,Rodrigues L,Rodrigues T,Junqueira VB,Videla LA

    更新日期:1998-07-01 00:00:00

  • Characterization of hydrogen peroxide and superoxide degrading pathways of Aspergillus niger catalase: a steady-state analysis.

    abstract::The oxidized intermediates generated upon exposure of Aspergillus niger catalase to hydrogen peroxide and superoxide radical fluxes were examined with UV-visible spectrophotometry. Hydrogen peroxide and superoxide radical were generated by means of glucose/glucose oxidase and xanthine/xanthine oxidase systems. Serial ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Lardinois OM,Rouxhet PG

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    abstract::Antioxidants are important species which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. A variety of free radical-scavenging antioxidants exist within the body many of which are derived from dietary sources. There is currently much interest in the antioxidant role ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Robinson EE,Maxwell SR,Thorpe GH

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  • Genes, ageing and longevity in humans: problems, advantages and perspectives.

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    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Salvioli S,Olivieri F,Marchegiani F,Cardelli M,Santoro A,Bellavista E,Mishto M,Invidia L,Capri M,Valensin S,Sevini F,Cevenini E,Celani L,Lescai F,Gonos E,Caruso C,Paolisso G,De Benedictis G,Monti D,Franceschi C

    更新日期:2006-12-01 00:00:00

  • Hydrogen peroxide constricts rat arteries by activating Na+-permeable and Ca2+-permeable cation channels.

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    pub_type: 杂志文章


    authors: Park HJ,Shin KC,Yoou SK,Kang M,Kim JG,Sung DJ,Yu W,Lee Y,Kim SH,Bae YM,Park SW

    更新日期:2019-01-01 00:00:00

  • Phosphate increases mitochondrial reactive oxygen species release.

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Oliveira GA,Kowaltowski AJ

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

    更新日期:2003-09-01 00:00:00

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Wu J,He Z,Gao Y,Zhang G,Huang X,Fang Q

    更新日期:2017-04-01 00:00:00

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Homma T,Fujii J

    更新日期:2020-04-20 00:00:00

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    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Yu PL,Lin TM,Wang SW,Wang PS

    更新日期:2012-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Ali SI,Alhusseini NF,Atteia HH,Idris RA,Hasan RA

    更新日期:2016-09-01 00:00:00