Mechanism of the anti-hypertensive property of the naturally occurring phenolic, malabaricone C in DOCA-salt rats.


:In this study, we studied whether chronic oral administration of the natural antioxidant, malabaricone C (mal C) can reduce blood pressure (BP) and attenuate cardio-vascular remodeling in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. The dose of mal C for its anti-hypertensive action was optimized by measuring the systolic BP (SBP). DOCA-salt rats showed very high SBP, associated with organ hypertrophy, collagen depositions, and inflammatory infiltrations in cardiac and aortic sections, reduced plasma total antioxidant status and NO level, and increased levels of TBARS, PGI2 as well as vasoconstrictors (AVP, Big ET, and ET-1). DOCA-salt also reduced smooth muscle- and endothelium-dependent vascular relaxation in rats. Mal C reversed all these changes of the DOCA-salt rats and improved their vascular reactivity. Mal C exerts anti-hypertensive property in DOCA-salt rats by reducing oxidative stress and organ hypertrophy, and improving endothelial and vascular functions. Given that mal C has appreciable natural abundance and is non-toxic to rodents, further studies would help in establishing its medicinal potential against hypertension.


Free Radic Res


Free radical research


Rathee JS,Patro BS,Brown L,Chattopadhyay S




Has Abstract


2016-01-01 00:00:00












  • Effects of esculetin on lipopolysaccharide (LPS)-induced acute lung injury via regulation of RhoA/Rho Kinase/NF-кB pathways in vivo and in vitro.

    abstract::The purpose of the present study was to investigate the protective effect of esculetin (ES) in lipopolysaccharide (LPS)-induced acute lung injury (ALI) and the lung epithelial A549 cells. Mice were intragastrically administered with ES (20 and 40 mg/kg) 1 h prior to LPS challenge. ES pretreatment at doses of 20 and 40...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Chen T,Guo Q,Wang H,Zhang H,Wang C,Zhang P,Meng S,Li Y,Ji H,Yan T

    更新日期:2015-01-01 00:00:00

  • A comparison between different methods for the determination of reduced and oxidized glutathione in mammalian tissues.

    abstract::In this study, three rapid assay techniques for the determination of glutathione, one enzymatic, one fluorometric and one newly patented colorimetric method, were compared by measuring reduced (GSH) and oxidized (GSSG) glutathione in guinea-pig heart and liver. The HPLC technique was used as a standard, since it is co...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Floreani M,Petrone M,Debetto P,Palatini P

    更新日期:1997-05-01 00:00:00

  • Coenzyme Q10 serves to couple mitochondrial oxidative phosphorylation and fatty acid β-oxidation, and attenuates NLRP3 inflammasome activation.

    abstract::Multiple acyl-CoA dehydrogenase deficiency (MADD), an autosomal recessive metabolic disorder of fatty acid metabolism, is mostly caused by mutations in the ETFA, ETFB or ETFDH genes that result in dysfunctions in electron transfer flavoprotein (ETF) or electron transfer flavoprotein-ubiquinone dehydrogenase (ETFDH). I...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Chokchaiwong S,Kuo YT,Lin SH,Hsu YC,Hsu SP,Liu YT,Chou AJ,Kao SH

    更新日期:2018-12-01 00:00:00

  • Postanoxic damage of microglial cells is mediated by xanthine oxidase and cyclooxygenase.

    abstract::Brain ischemia and the following reperfusion are important causes for brain damage and leading causes of brain morbidity and human mortality. Numerous observations exist describing the neuronal damage during ischemia/reperfusion, but the outcome of such conditions towards glial cells still remains to be elucidated. Mi...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Widmer R,Engels M,Voss P,Grune T

    更新日期:2007-02-01 00:00:00

  • Inactivation of mitochondrial NADP+-dependent isocitrate dehydrogenase by hypochlorous acid.

    abstract::Myeoloperoxidase catalyses the formation of hypochlorous acid (HOCl) via reaction of H(2)O(2) with Cl(-) ion. Although HOCl is known to play a major role in the human immune system by killing bacteria and other invading pathogens, excessive generation of this oxidant is known to cause damage to tissue. Recently, it wa...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Park SY,Lee SM,Shin SW,Park JW

    更新日期:2008-05-01 00:00:00

  • A(1) and A(3) adenosine receptors alter glutathione status in an organ-specific manner and influence the changes after inhibition of gamma-glutamylcysteine ligase.

    abstract::Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

    更新日期:2009-03-01 00:00:00

  • NOX2 activated by α1-adrenoceptors modulates hepatic metabolic routes stimulated by β-adrenoceptors.

    abstract::The NADPH oxidase (NOX) family of enzymes oxidase catalyzes the transport of electrons from NADPH to molecular oxygen and generates O(2)(•-), which is rapidly converted into H(2)O(2). We aimed to identify in hepatocytes the protein NOX complex responsible for H(2)O(2) synthesis after α(1)-adrenoceptor (α(1)-AR) stimul...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Diaz-Cruz A,Vilchis-Landeros MM,Guinzberg R,Villalobos-Molina R,Piña E

    更新日期:2011-11-01 00:00:00

  • Membrane raft redox signalosomes in endothelial cells.

    abstract::Membrane rafts (MRs) are specialized microdomains in the cell membrane with an altered lipid composition. Upon various stimulations, MRs can be clustered to aggregate or recruit NADPH oxidase sub-units and related proteins to form MR redox signalosomes in the membrane of cells like vascular endothelial cells (ECs). Mu...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Zhang C,Li PL

    更新日期:2010-08-01 00:00:00

  • Peroxynitrite oxidizes erythrocyte membrane band 3 protein and diminishes its anion transport capacity.

    abstract::We describe an altered membrane band 3 protein-mediated anion transport in erythrocytes exposed to peroxynitrite, and relate the loss of anion transport to cell damage and to band 3 oxidative modifications. We found that peroxynitrite down-regulate anion transport in a dose dependent relation (100-300 micromoles/l). H...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Celedón G,González G,Pino J,Lissi EA

    更新日期:2007-03-01 00:00:00

  • Cold stress on Araucaria angustifolia embryogenic cells results in oxidative stress and induces adaptation: implications for conservation and propagation.

    abstract::Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Dorigan de Matos Furlanetto AL,Valente C,Martinez GR,Merlin Rocha ME,Maurer JBB,Cadena SMSC

    更新日期:2019-01-01 00:00:00

  • Absence of synproportionation between oxy and ferryl leghemoglobin. off.

    abstract::The synproportionation reaction between ferryl leghemoglobin and oxyleghemoglobin does not occur, at least under conditions where this process could be clearly demonstrated with myoglobin and hemoglobin. In contrast, a cross synproportionation can occur between oxyleghemoglobin and ferryl myoglobin or between ferryl l...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Mathieu C,Swaraj K,Davies MJ,Trinchant JC,Puppo A

    更新日期:1997-08-01 00:00:00

  • No significant paraquat-induced oxidative DNA damage in rats.

    abstract::The metabolism of paraquat generates oxygen radicals. Paraquat has thus been suggested as a model compound to induce oxidative damage to DNA, lipids and proteins in different cells and tissues, although experimental data are inconsistent. In order to explore the possibilities for an animal model of oxidative DNA damag...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Sørensen M,Loft S

    更新日期:2000-05-01 00:00:00

  • Levels of 8-oxo-dGsn and 8-oxo-Gsn in random urine are consistent with 24 h urine in healthy subjects and patients with renal disease.

    abstract::Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have s...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Mao YH,Weng QH,Xu LN,Li XY,Zhao B,Sun Y,Nie JJ,Hu JH,Zhou Q,Zhang LQ,Guo J,Zuo MZ,Ito S,Cai JP

    更新日期:2017-06-01 00:00:00

  • p38 MAPK and Ca2+ contribute to hydrogen peroxide-induced increase of permeability in vascular endothelial cells but ERK does not.

    abstract::To examine the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) in the oxidative stress-induced increase of permeability in endothelial cells, the effects of a p38 MAPK inhibitor (SB203580) and ERK inhibitor (PD90859) on the H2O2-induced increase of permeab...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Niwa K,Inanami O,Ohta T,Ito S,Karino T,Kuwabara M

    更新日期:2001-11-01 00:00:00

  • Comparison of results from different laboratories in measuring 8-oxo-2'-deoxyguanosine in synthetic oligonucleotides.

    abstract::The European Standards Committee on Oxidative DNA Damage (ESCODD) was set up in 1997 to resolve methodological problems and to reach agreement on the basal level of 8-oxo-2'-deoxyguanosine (8-oxodG) in biological samples. In the present ESCODD trial 6 samples of 8-oxodG-containing oligonucleotides with different ratio...

    journal_title:Free radical research

    pub_type: 杂志文章,多中心研究


    authors: Riis B

    更新日期:2002-06-01 00:00:00

  • Effect of complexation with randomly methylated beta-cyclodextrin on the aqueous solubility, photostability and antioxidant activity of an indolinonic nitroxide radical.

    abstract::The interaction between the hydrophobic indolinonic nitroxide radical, 1,2-dihydro-2-methyl-2-phenyl-3H-indole-3-one-1-oxyl and hydrophilic alpha-, beta- and gamma-cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins, random methyl-beta-cyclodextrin (RM-beta-...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Damiani E,Tursilli R,Casolari A,Astolfi P,Greci L,Scalia S

    更新日期:2005-01-01 00:00:00

  • Antioxidant properties of catechins and proanthocyanidins: effect of polymerisation, galloylation and glycosylation.

    abstract::A range of catechins and oligomeric procyanidins was purified by high performance liquid chromatography (HPLC) from grape seed, apple skin, lentil and almond flesh. Catechins, galloylated epicatechin, glycosylated catechin, procyanidin dimers, galloylated dimers, trimer, and tetramer species were all identified, purif...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Plumb GW,De Pascual-Teresa S,Santos-Buelga C,Cheynier V,Williamson G

    更新日期:1998-10-01 00:00:00

  • Nitric oxide scavenging by cell-free hemoglobin may be a primary factor determining hypertension in polycythemic patients.

    abstract::We tested the hypothesis that hypertension associated with polycythemia vera (PV) may be related to hemoglobin released from erythrocytes (cell-free hemoglobin, fHb). We assessed hematocrit, mean arterial pressure (MAP), blood viscosity, and the level of fHb and nitrite/nitrate (NOx) in the plasma of 73 PV patients an...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Rusak T,Misztal T,Piszcz J,Tomasiak M

    更新日期:2014-02-01 00:00:00

  • PKCδ phosphorylation is an upstream event of GSK3 inactivation-mediated ROS generation in TGF-β1-induced senescence.

    abstract::Transforming growth factor β1 (TGF-β1) induces Mv1Lu cell senescence through inactivating glycogen synthase kinase 3 (GSK3), thereby inactivating complex IV and increasing intracellular ROS. In the present study, we identified protein kinase C delta (PKCδ) as an upstream regulator of GSK3 inactivation in this mechanis...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Byun HO,Jung HJ,Kim MJ,Yoon G

    更新日期:2014-09-01 00:00:00

  • The Cu/Zn superoxide dismutase +35A/C (rs2234694) variant correlates with altered levels of protein carbonyls and glutathione and associates with severity of COPD in a Tunisian population.

    abstract::Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Ben Anes A,Ben Nasr H,Garrouche A,Bchir S,Dhaouefi Z,Chabchoub E,Tabka Z,Chahed K

    更新日期:2019-03-01 00:00:00

  • Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism.

    abstract::There is a correlation between oxidative stress generated by diethylnitrosamine (DEN) metabolism and liver cancer development. Quercetin is a flavonoid with anti-carcinogenic and antioxidant properties. This study demonstrates the mechanism of action for the chemopreventive effect of quercetin. A 10 mg/kg dose of quer...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Vásquez-Garzón VR,Arellanes-Robledo J,García-Román R,Aparicio-Rautista DI,Villa-Treviño S

    更新日期:2009-02-01 00:00:00

  • Hydroxyl radical scavenging activity of nonsteroidal anti-inflammatory drugs.

    abstract::The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping techniq...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Kataoka M,Tonooka K,Ando T,Imai K,Aimoto T

    更新日期:1997-10-01 00:00:00

  • Late-intervention study with ebselen in an experimental model of type 1 diabetic nephropathy.

    abstract:BACKGROUND AND AIM:Previous studies have shown that preventive treatment with the antioxidant, ebselen, in experimental models of type 1 diabetic nephropathy resulted in an attenuation of structural and functional damage in the kidney. However, evidence for the effectiveness of ebselen in late-intervention studies is l...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Tan SM,Sharma A,Stefanovic N,de Haan JB

    更新日期:2015-03-01 00:00:00

  • Bicarbonate-dependent, carbonate radical anion-driven tocopherol-mediated human LDL peroxidation: an in vitro and in vivo study.

    abstract::We have here investigated possible occurrence of bicarbonate-dependent, carbonate radical anion (CO(3)(•-))-driven tocopherol-mediated human LDL peroxidation (TMP) in vitro and in vivo. CO(3)(•-), generated in vitro by the SOD1/H(2)O(2)/bicarbonate system, readily promoted TMP, which was dependent on α-tocopherol and ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Lapenna D,Ciofani G,Cuccurullo C,Neri M,Giamberardino MA,Cuccurullo F

    更新日期:2012-11-01 00:00:00

  • Protective effects of Alpha-lipoic acid on MeHg-induced oxidative damage and intracellular Ca(2+) dyshomeostasis in primary cultured neurons.

    abstract::Methylmercury (MeHg) is one of the ubiquitous environmental toxicant that leads to long-lasting neurological deficits in animals and humans. However, the mechanisms of MeHg-induced neuronal cell death are incompletely understood. Treatment of neuronal cells with MeHg (0-2 μM) for 0.5-12 h, or pretreated with LA (12.5-...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Yang T,Xu Z,Liu W,Xu B,Deng Y

    更新日期:2016-01-01 00:00:00

  • Thioredoxin, an anti-oxidant protein, protects mouse embryos from oxidative stress-induced developmental anomalies.

    abstract::During the early postimplantation period, rodent embryos survive in a relatively anaerobic environment in utero and are vulnerable to a high oxygen pressure. They become resistant to oxygen stress when they are exposed to a higher oxygen pressure after the uteroplacental circulation is established. However, it is unkn...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Kobayashi-Miura M,Nakamura H,Yodoi J,Shiota K

    更新日期:2002-09-01 00:00:00

  • Qualitative analysis of phospholipids and their oxidised derivatives - used techniques and examples of their applications related to lipidomic research and food analysis.

    abstract::Phospholipids (PLs) are important biomolecules that not only constitute structural building blocks and scaffolds of cell and organelle membranes but also play a vital role in cell biochemistry and physiology. Moreover, dietary exogenous PLs are characterised by high nutritional value and other beneficial health effect...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Parchem K,Sasson S,Ferreri C,Bartoszek A

    更新日期:2019-01-01 00:00:00

  • Implications of lag time concept in the oxidation of LDL.

    abstract::Oxidation of low density lipoprotein (LDL) has been implicated in the pathogenesis of atherosclerosis. The most common technique for measuring the oxidation of lipoproteins is the continuous measurement of the formation of conjugated diene at OD 234 nm. The concept of "lag time", derived from such measurements, has be...

    journal_title:Free radical research

    pub_type: 杂志文章,评审


    authors: Parthasarathy S,Augé N,Santanam N

    更新日期:1998-06-01 00:00:00

  • Myocardial antioxidant defense mechanisms: time related changes after reperfusion of the ischemic rat heart.

    abstract::It is well known that reperfusion damage of ischemic myocardium may be attributed to alterations in the antioxidant defense system against free radical aggression. In addition, the degree of myocardial damage may depend on the duration and severity of ischemia that precedes reperfusion. We carried out serial ischemic ...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Porreca E,Del Boccio G,Lapenna D,Di Febbo C,Pennelli A,Cipollone F,Di Ilio C,Cuccurullo F

    更新日期:1994-03-01 00:00:00

  • Haem oxygenase-1 inhibits neointimal hyperplasia in rat by histone deacetylase 2.

    abstract::It has been reported that haem oxygenase-1 (Hmox1) induction attenuates neointimal thickening. Here we further investigated the potential mechanisms regulating this important pathological process. We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this in...

    journal_title:Free radical research

    pub_type: 杂志文章


    authors: Ni J,Yang W,Shen W,Zhang R

    更新日期:2018-10-01 00:00:00