Increased nitration and diminished activity of copper/zinc superoxide dismutase in placentas from diabetic rats.

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:The risk of chronic oxidative stress in the retinal pigment epithelium (RPE) increases with age due to accumulation of the photoreactive age pigment lipofuscin (LFG). Here, we asked whether sublethal and weakly lethal photic stress, induced by irradiation of ARPE-19 cells containing phagocytised LFG, affected the cell...

journal_title：Free radical research

authors： Olchawa MM,Furso JA,Szewczyk GM,Sarna TJ

更新日期：2017-10-01 00:00:00

abstract：:Liver microsomal functions related to xenobiotic biotransformation and free radical production were studied in control rats and in animals subjected to L-3,3',5-triiodothyronine (T3) and/or lindane administration as possible mechanisms contributing to oxidative stress, in relation to the activity of enzymes (superoxid...

journal_title：Free radical research

authors： Simon Giavarotti KA,Rodrigues L,Rodrigues T,Junqueira VB,Videla LA

更新日期：1998-07-01 00:00:00

abstract：:The NADPH oxidase (NOX) family of enzymes oxidase catalyzes the transport of electrons from NADPH to molecular oxygen and generates O(2)(•-), which is rapidly converted into H(2)O(2). We aimed to identify in hepatocytes the protein NOX complex responsible for H(2)O(2) synthesis after α(1)-adrenoceptor (α(1)-AR) stimul...

journal_title：Free radical research

authors： Diaz-Cruz A,Vilchis-Landeros MM,Guinzberg R,Villalobos-Molina R,Piña E

更新日期：2011-11-01 00:00:00

abstract：:We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...

journal_title：Free radical research

authors： Buko VU,Artsukevich A,Zavodnik I,Maltsev A,Sushko L,Zimmermann T,Dianzani MU

更新日期：1996-11-01 00:00:00

abstract：:C-phycocyanins, major biliproteins of blue green algae (cyanobacteria), widely used as colourants in food and cosmetics are known for their antioxidant as well as therapeutic potential. Recent claims indicating phycobiliproteins exert stronger photodynamic action on tumor cells than clinically approved hematoporphyrin...

journal_title：Free radical research

authors： Paul BT,Patel A,Selvam GS,Mishra S,Ghosh PK,Murugesan R

更新日期：2006-08-01 00:00:00

abstract：:Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer's, Parkinson's and prion diseases and their respective animal models. While the causes of oxidative stress are relatively well-documented, the effects of chronically reducing oxidative stress on cognition, patholo...

journal_title：Free radical research

authors： Siedlak SL,Casadesus G,Webber KM,Pappolla MA,Atwood CS,Smith MA,Perry G

更新日期：2009-02-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular proteolytic systems that are closely associated with each other. Because UPS and autophagy are involved in the clearance of oxidised and/or aggregated proteins, it would be logical to assume that alterations in proteolysis would accompany ...

journal_title：Free radical research

authors： Homma T,Fujii J

更新日期：2020-04-20 00:00:00

abstract：:Gamma-glutamylcysteine synthetase (GCS; also referred to as glutamate-cysteine ligase, GLCL) catalyzes the rate-limiting reaction in glutathione (GSH) biosynthesis. The GCS holoenzyme is composed of a catalytic and regulatory subunit, each encoded by a unique gene. In addition to some conditions which specifically upr...

journal_title：Free radical research

authors： Wild AC,Mulcahy RT

更新日期：2000-04-01 00:00:00

abstract：:In severe COPD patients, oxidative stress, which is involved in their peripheral muscle dysfunction, increases in response to exercise. In this study, muscle oxidative stress was explored after quadriceps magnetic stimulation training. A randomized controlled study was conducted on very severe COPD patients, who under...

journal_title：Free radical research

authors： Bustamante V,Casanova J,López de Santamaría E,Mas S,Sellarés J,Gea J,Gáldiz JB,Barreiro E

更新日期：2008-11-01 00:00:00

abstract：:A zinc(II) phthalocyanine compound, tetra-alpha-(2,2,4-tirmethyl-3-pentoxy) Phthalocyanine Zinc (ZnPc(OR)(4)) was synthesized in this paper and this zinc (II) phthalocyanine compound was used as the photosensitizer in the photoinduced chemiluminescence (PCL) of lucigenin in N,N-dimethylformamide (DMF). The photoexcite...

journal_title：Free radical research

authors： Wang J,Jiang Z,Huang L,Huang J,Chen G

更新日期：2008-02-01 00:00:00

abstract：:The cyanidin-3-O-beta-glucopyranoside (C-3-G) antioxidant capacity towards reactive oxygen species (ROS)-mediated damages was assessed in tissue and cells submitted to increased oxidative stress. In the isolated ischemic and reperfused rat heart, 10 or 30 degreesM C-3-G protected from both lipid peroxidation (66.7 and...

journal_title：Free radical research

authors： Amorini AM,Lazzarino G,Galvano F,Fazzina G,Tavazzi B,Galvano G

更新日期：2003-04-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00

abstract：:It has previously been reported that the globular form of adiponectin (gAd), mature adipocyte-derived cytokine, induced generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated whether diacylglycerol kinases (DGKs), enzymes functioning in sub...

journal_title：Free radical research

authors： Kamio N,Akifusa S,Yamashita Y

更新日期：2011-03-01 00:00:00

abstract：:Adriamycin (ADR) is a chemotherapeutic agent useful in treating various cancers. ADR is a quinone-containing anthracycline chemotherapeutic and is known to produce reactive oxygen species (ROS) in heart. Application of this drug can have serious side effects in various tissues, including brain, apart from the known ca...

journal_title：Free radical research

authors： Joshi G,Sultana R,Tangpong J,Cole MP,St Clair DK,Vore M,Estus S,Butterfield DA

更新日期：2005-11-01 00:00:00

abstract：:Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...

journal_title：Free radical research

authors： Laggner H,Schreier S,Hermann M,Exner M,Mühl A,Gmeiner BM,Kapiotis S

更新日期：2007-02-01 00:00:00

abstract：:It is well known that antioxidants such as AA (reduced ascorbate), glutathione (GSH) (reduced glutathione) and melatonin can delay seed ageing. Can they recover aged seed? Artificial aged maize seeds were obtained and their reduced germination rate (GR) and high lipid peroxidation were recorded. Exogenous melatonin wa...

journal_title：Free radical research

authors： Deng B,Yang K,Zhang Y,Li Z

更新日期：2017-10-01 00:00:00

abstract：:Approaching living systems, aqueous solutions are appropriate to characterize antioxidants, whereas the frequently used standard 1,1-diphenyl-2-picrylhydrazyl (DPPH) is insoluble in water. Therefore, mixed water-ethanol solvents were investigated using the electron paramagnetic resonance (EPR) spectroscopy. Two forms ...

journal_title：Free radical research

authors： Stasko A,Brezová V,Biskupic S,Misík V

更新日期：2007-04-01 00:00:00

abstract：:We studied the effects of a single post whole-body low-dose irradiation (50 cGy of gamma-ray) on mice with ferric nitrilotriacetate (Fe3+-NTA)-induced transient hepatopathy. As a result, low-dose irradiation accelerated the rate of recovery. Based on the changes in glutamic oxaloacetic transaminase (GOT) activities, g...

journal_title：Free radical research

authors： Yamaoka K,Kojima S,Nomura T

更新日期：2000-03-01 00:00:00

abstract：:Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

journal_title：Free radical research

authors： Dutta A,Gupta ML,Verma S

更新日期：2018-01-01 00:00:00

abstract：:Hispidulin (6-methoxy-5,7,4'-trihydroxyflavone) and eupafolin (6-methoxy-5,7,3',4'-tetrahydroxyflavone), are flavonoids found in the leaves of Eupatorium litoralle. They have recognized antioxidant and antineoplastic properties, although their action mechanisms have not been previously described. We now report the eff...

journal_title：Free radical research

authors： Dabaghi-Barbosa P,Mariante Rocha A,Franco da Cruz Lima A,Heleno de Oliveira B,Benigna Martinelli de Oliveira M,Gunilla Skare Carnieri E,Cadena SM,Eliane Merlin Rocha M

更新日期：2005-12-01 00:00:00

abstract：:We investigated the effects of fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, on reactive oxygen species (ROS) and on oxidative DNA damage in vitro, as well as the effects of the main fluvastatin metabolites (M2, M3, and M4) and other inhibitors of the same enzyme, pravastatin and simvastati...

journal_title：Free radical research

authors： Imaeda A,Tanigawa T,Aoki T,Kondo Y,Nakamura N,Yoshikawa T

更新日期：2001-12-01 00:00:00

abstract：:Penicillins, as bactericidal antibiotics, have been widely used to treat infections for several decades. Their structure contains both aromatic and thioether moieties susceptible to free radical oxidation. The (•)OH induced oxidation mechanism of amoxicillin was investigated by pulse radiolysis techniques and by final...

journal_title：Free radical research

authors： Szabó L,Tóth T,Rácz G,Takács E,Wojnárovits L

更新日期：2016-01-01 00:00:00

abstract：:This experiment was performed to clarify the role of protein kinase C (PKC) delta in NADPH oxidase-dependent O(2-) production and actin polymerization followed by phagocytosis in neutrophils. Bovine neutrophils and human neutrophil-like differentiated HL-60 (dHL-60) cells were stimulated with serum-opsonized zymosan (...

journal_title：Free radical research

authors： Waki K,Inanami O,Yamamori T,Nagahata H,Kuwabara M

更新日期：2006-04-01 00:00:00

abstract：:5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO), a new cyclic DEPMPO-type nitrone was evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. CYPMPO is colorless crystalline and freely soluble in water. Both the solid and diluted aqueous solution did not dev...

journal_title：Free radical research

authors： Kamibayashi M,Oowada S,Kameda H,Okada T,Inanami O,Ohta S,Ozawa T,Makino K,Kotake Y

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...

journal_title：Free radical research

authors： Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue M

更新日期：2004-04-01 00:00:00

abstract：:Neuroblastoma (NB) is one of the most frequent extracranial solid tumors in children. It accounts for 8-10% of all childhood cancer deaths, and there is a need for development of new drugs for its treatment. Curcumin (diferuloylmethane), a major active component of turmeric (Curcuma longa), has been shown to exert ant...

journal_title：Free radical research

authors： Picone P,Nuzzo D,Caruana L,Messina E,Scafidi V,Di Carlo M

更新日期：2014-12-01 00:00:00

abstract：:Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

journal_title：Free radical research

authors： Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

更新日期：2009-03-01 00:00:00

abstract：:Cigarette smoking is associated with increased oxidative stress and increased risk of degenerative disease. As the major lipophilic antioxidant, requirements for vitamin E may be higher in smokers due to increased utilisation. In this observational study we have compared vitamin E status in smokers and non-smokers usi...

journal_title：Free radical research

authors： Jeanes YM,Hall WL,Proteggente AR,Lodge JK

更新日期：2004-08-01 00:00:00