Abstract:
:In addition to insulin, glycemic control involves thyroid hormones. However, an excess of thyroid hormone can disturb the blood glucose equilibrium, leading to alterations of carbohydrate metabolism and, eventually, diabetes. Indeed, experimental and clinical hyperthyroidism is often accompanied by abnormal glucose tolerance. A common characteristic of hyperthyroidism and type 2 diabetes is the altered mitochondrial efficiency caused by the enhanced production of reactive oxygen and nitrogen species. It is known that an excess of thyroid hormone leads to increased oxidant production and mitochondrial oxidative damage. It can be hypothesised that these species represent the link between hyperthyroidism and development of insulin resistance and diabetes, even though direct evidence of this relationship is lacking. In this review, we examine the literature concerning the effects of insulin and thyroid hormones on glucose metabolism and discuss alterations of glucose metabolism in hyperthyroid conditions and the cellular and molecular mechanisms that may underline them.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Venditti P,Reed TT,Victor VM,Di Meo Sdoi
10.1080/10715762.2019.1590567subject
Has Abstractpub_date
2019-03-01 00:00:00pages
248-268issue
3eissn
1071-5762issn
1029-2470journal_volume
53pub_type
杂志文章,评审abstract::Diosgenin possesses anti-inflammatory and anticancer properties. Activated neutrophils produce high concentrations of the superoxide anion which is involved in the pathophysiology of inflammation-related diseases and cancer. In the present study, the inhibitory effect and possible mechanisms of diosgenin on superoxide...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.966705
更新日期:2014-12-01 00:00:00
abstract::The brain is highly susceptible to oxidative stress due to its high metabolic demand. Increased oxidative stress and depletion of glutathione (GSH) are observed with aging and many neurological diseases. Exercise training has the potential to reduce oxidative stress in the brain. In this study, nine healthy sedentary ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1411594
更新日期:2018-01-01 00:00:00
abstract::There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation of the amyloid proteins associated with some of these diseases. Hydrog...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600632545
更新日期:2006-07-01 00:00:00
abstract::The effects of inorganic phosphate (Pi), the main intracellular membrane permeable anion capable of altering mitochondrial pH gradients (Delta pH), were measured on mitochondrial H2O2 release. As expected, Pi decreased Delta pH and increased the electric membrane potential (Delta Psi). Mitochondrial H2O2 release was s...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400009258
更新日期:2004-10-01 00:00:00
abstract::Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000301011
更新日期:2000-11-01 00:00:00
abstract::The antioxidative activity of hydroxylamines was evaluated for the oxidation of tetralin at 61 degrees C and linoleic acid micelles in an aqueous dispersion at 37 degrees C, induced by an azo initiator. The antioxidative efficacy of the hydroxylamines for the oxidation of tetralin was smaller than that of alpha-tocoph...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100301391
更新日期:2001-12-01 00:00:00
abstract::N-nitroso species have recently been detected in animal tissues. Protein N-nitrosotryptophan is the best candidate for this N-nitroso pool. N-nitrosation of N-blocked trytophan derivatives like melatonin (MelH) by N2O3 or peroxynitrite (ONOOH/ONOO- ) has been observed under conditions of pH and reagent concentrations ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600693414
更新日期:2006-09-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.904507
更新日期:2014-07-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2015.1036052
更新日期:2015-01-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
abstract::There is a correlation between oxidative stress generated by diethylnitrosamine (DEN) metabolism and liver cancer development. Quercetin is a flavonoid with anti-carcinogenic and antioxidant properties. This study demonstrates the mechanism of action for the chemopreventive effect of quercetin. A 10 mg/kg dose of quer...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760802626535
更新日期:2009-02-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400017376
更新日期:2004-11-01 00:00:00
abstract::Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609088023
更新日期:1996-04-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2015.1089987
更新日期:2015-01-01 00:00:00
abstract::Macrophages produce reactive oxygen species such as O2-, H2O2 and *OH that contribute to the pathogenesis of diseases such as inflammation and atherosclerosis. The cells have multiple defense systems against those reactive oxygen species, and we describe here such an oxidative stress-inducible defense system. Upon exp...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715769900300921
更新日期:1999-10-01 00:00:00
abstract::Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have s...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1346249
更新日期:2017-06-01 00:00:00
abstract::Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the stu...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715760600917136
更新日期:2006-12-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/13561820500177659
更新日期:2005-12-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769709097868
更新日期:1997-12-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576031000136568
更新日期:2003-08-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2011.574290
更新日期:2011-08-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760600803823
更新日期:2006-09-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1290233
更新日期:2017-02-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300621
更新日期:2001-07-01 00:00:00
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journal_title:Free radical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/10715760000300951
更新日期:2000-10-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2013.821200
更新日期:2013-11-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1764948
更新日期:2020-05-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
abstract::Epidemiology studies have shown that consumption of fruits and vegetables is associated with the prevention of chronic diseases such as cancer and cardiovascular disease. Induction of cellular phase II detoxifying enzymes is associated with cancer preventive potential. Phenolsulfotransferases (PSTs) are traditionally ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500150424
更新日期:2005-08-01 00:00:00