Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism.

Abstract:

:There is a correlation between oxidative stress generated by diethylnitrosamine (DEN) metabolism and liver cancer development. Quercetin is a flavonoid with anti-carcinogenic and antioxidant properties. This study demonstrates the mechanism of action for the chemopreventive effect of quercetin. A 10 mg/kg dose of quercetin produced drastic effect, when it is administrated 2 h before DEN; at 24 days post-DEN, a 70.3% and 66.2% decrease in total area and number of preneoplastic lesions were observed, respectively. At 12 h post-DEN, quercetin inhibited levels of lipid peroxidation by 40%. Quercetin increased the levels of both GSH and of total glutathione, it increased the GSH/GSSG index and it caused a rapid and simultaneous elevation in the activities of superoxide dismutase, glutathione peroxidase and catalase. In conclusion, the quercetin mechanism of action is due to promote the enzymatic and non-enzymatic antioxidant defense system during the initiation of hepatocarcinogenesis.

journal_name

Free Radic Res

journal_title

Free radical research

authors

Vásquez-Garzón VR,Arellanes-Robledo J,García-Román R,Aparicio-Rautista DI,Villa-Treviño S

doi

10.1080/10715760802626535

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

128-37

issue

2

eissn

1071-5762

issn

1029-2470

pii

907243536

journal_volume

43

pub_type

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