Thioredoxin, an anti-oxidant protein, protects mouse embryos from oxidative stress-induced developmental anomalies.

Abstract:

:During the early postimplantation period, rodent embryos survive in a relatively anaerobic environment in utero and are vulnerable to a high oxygen pressure. They become resistant to oxygen stress when they are exposed to a higher oxygen pressure after the uteroplacental circulation is established. However, it is unknown how embryos acquire such resistance against oxidative stress. This study was undertaken to examine whether an antioxidant protein thioredoxin (TRX) plays a significant role in the embryonic acquisition of the tolerance to oxidative stress. E7.5 embryos of C57BL/6 wild-type (WT) and human TRX (hTRX) inserted-transgenic (Tg) embryos were cultured under 10 or 25% O2 and their growth and morphological differentiation were evaluated. The TRX expression and the products of oxidative stress (8-hydroxy-2'-deoxy-guanosine and carbonylated proteins) in their tissues were also examined. When WT embryos were cultivated in vitro under 25% O2, their growth was significantly disturbed and various developmental abnormalities were induced, which did not occur in embryos grown under 10% O2. However, such embryotoxic effects of oxygen were significantly attenuated in the hTRX Tg embryos that continuously express hTRX. Accumulation of the products of oxidative stress was significantly reduced in hTRX Tg embryos as compared with that in WT embryos. The TRX transgene appears to provide the embryo with the resistance against oxidative stress and may play a crucial role in the redox regulation in embryos.

journal_name

Free Radic Res

journal_title

Free radical research

authors

Kobayashi-Miura M,Nakamura H,Yodoi J,Shiota K

doi

10.1080/1071576021000006626

keywords:

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

949-56

issue

9

eissn

1071-5762

issn

1029-2470

journal_volume

36

pub_type

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