Abstract:
BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced renal injury. METHODS:Edaravone, 3-methyl-1-phenyl-pyrazolin-5-one, was administrated intravenously at a dose of 30 mg/kg of body weight to male Wistar rats (200-220 g). After 30 min, cisplatin was injected intraperitoneally at a dose of 5 mg/kg of body weight. At the indicated times after the treatment, functions and histological changes of the kidney were analyzed. To test the therapeutic potential of edaravone in chemotherapy, its effect on the anticancer action of cisplatin was examined in ascites cancer-bearing rats. RESULTS:We found that cisplatin rapidly impaired the respiratory function and DNA of mitochondria in renal proximal tubules, thereby inducing apoptosis of tubular epithelial cells within a few days and chronic renal dysfunction associated with multiple cysts one-year after the administration. Administration of edaravone inhibited the cisplatin-induced acute injury of mitochondria and their DNA and renal epithelial cell apoptosis as well as the occurrence of chronic renal dysfunction and multiple cyst formation. The anticancer effect of cisplatin remained unaffected by intravenous administrating of edaravone. CONCLUSIONS:These results indicate that edaravone may have therapeutic potential for inhibiting the acute and chronic injury of the kidney induced by cisplatin.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue Mdoi
10.1080/10715760310001646886keywords:
subject
Has Abstractpub_date
2004-04-01 00:00:00pages
333-41issue
4eissn
1071-5762issn
1029-2470journal_volume
38pub_type
杂志文章abstract::In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various cells from L-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO includes oxidation to nitrate by oxyhaemoglobin in red blood cells and autoxidation in haemoglobin-free media to nitrite. Nitrate and ni...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715760500053651
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abstract::We describe an altered membrane band 3 protein-mediated anion transport in erythrocytes exposed to peroxynitrite, and relate the loss of anion transport to cell damage and to band 3 oxidative modifications. We found that peroxynitrite down-regulate anion transport in a dose dependent relation (100-300 micromoles/l). H...
journal_title:Free radical research
pub_type: 杂志文章
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章
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journal_title:Free radical research
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abstract::This experiment was performed to clarify the role of protein kinase C (PKC) delta in NADPH oxidase-dependent O(2-) production and actin polymerization followed by phagocytosis in neutrophils. Bovine neutrophils and human neutrophil-like differentiated HL-60 (dHL-60) cells were stimulated with serum-opsonized zymosan (...
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:
更新日期:2000-11-01 00:00:00
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章,评审
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更新日期:2014-08-01 00:00:00
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journal_title:Free radical research
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abstract::Gamma-glutamyltransferase (GGT) plays a central role in the homeostasis of the antioxidant glutathione (GSH). The expression of GGT has been shown to be upregulated after oxidative stress, but the signalling pathways implicated remain poorly characterized. The results here show that acute exposure of CC531 cells to ox...
journal_title:Free radical research
pub_type: 杂志文章
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更新日期:2007-12-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
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更新日期:2016-09-01 00:00:00
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journal_title:Free radical research
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更新日期:2000-07-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.660527
更新日期:2012-05-01 00:00:00
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journal_title:Free radical research
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doi:10.1080/10715760100301531
更新日期:2001-11-01 00:00:00
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2008-11-01 00:00:00
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journal_title:Free radical research
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-09-01 00:00:00
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journal_title:Free radical research
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更新日期:1995-11-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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更新日期:2021-01-27 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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journal_title:Free radical research
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更新日期:1997-12-01 00:00:00
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journal_title:Free radical research
pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
abstract::Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1457217
更新日期:2018-05-01 00:00:00