Reaction of ferrate (VI)/ferrate (V) with hydrogen peroxide and superoxide anion--a stopped-flow and premix pulse radiolysis study.

abstract：:Oxidized low density lipoprotein (LDL) has a major impact in the development of atherosclerosis. Risk for oxidative modification of LDL is usually determined indirectly by measuring the capability of LDL to resist radical insult. We compared three different methods quantifying the antioxidative capacity of LDL ex vivo...

journal_title：Free radical research

authors： Malminiemi K,Palomäki A,Malminiemi O

更新日期：2000-11-01 00:00:00

abstract：:Carotenoids scavenge simple lipid-like alkylperoxyl radicals. However, the rate constant is too low to be determined directly and the mechanism is likewise not known with certainty [Mortensen, A. and Skibsted, L.H. (1998) FEBS Lett. 426, 392-396]. It is demonstrated that carotenoids react with peroxyl radicals only sl...

journal_title：Free radical research

authors： Mortensen A

更新日期：2002-02-01 00:00:00

abstract：:Antioxidants are important species which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. A variety of free radical-scavenging antioxidants exist within the body many of which are derived from dietary sources. There is currently much interest in the antioxidant role ...

journal_title：Free radical research

authors： Robinson EE,Maxwell SR,Thorpe GH

更新日期：1997-03-01 00:00:00

abstract：:Adenosine is an endogenous cardioprotective substance. The present study examines whether exogenous adenosine attenuates cardiac injury induced by oxidative stress. Rat hearts (Langendorff model) were perfused with H2O2 (180 microM) for 10 min, then recovered for 60 min (n = 10). In other groups adenosine 55 microM, 1...

journal_title：Free radical research

authors： Valen G,Vaage J

更新日期：1996-01-01 00:00:00

abstract：:Orellanine is the tetrahydroxylated and di-N-oxidized bipyridine toxin extracted from several Cortinarius mushrooms among them C. orellanus. The pathogenic mechanism involved in the C. orellanus-poisoning by orellanine leading to kidney impairment is not yet fully understood until now. Electron spin resonance (ESR) sp...

journal_title：Free radical research

authors： Oubrahim H,Richard JM,Cantin-Esnault D

更新日期：1998-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is characterized by synovial proliferation and migration which is induced by proinflammatory cytokines or oxidative stress, followed by joint destruction. Edaravone, clinically available free radical scavenger in Japan, is confirmed to be beneficial in the acute stage of cerebral infarction. ...

journal_title：Free radical research

authors： Arii K,Kumon Y,Ikeda Y,Suehiro T,Hashimoto K

更新日期：2006-02-01 00:00:00

abstract：:The increasing knowledge on the participation of free radicals in many diverse clinical and pathological conditions, has consequently expanded the search for new and versatile antioxidants aimed at combating oxidative stress. Our interest in this field concerns aromatic indolinonic aminoxyls (nitroxides) which efficie...

journal_title：Free radical research

authors： Damiani E,Carloni P,Stipa P,Greci L

更新日期：1999-08-01 00:00:00

abstract：:Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an important antioxidant. Because of its hydrophobicity and large molecular weight, absorption of dietary CoQ10 is slow and limited...

journal_title：Free radical research

authors： Bhagavan HN,Chopra RK

更新日期：2006-05-01 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) induces Mv1Lu cell senescence through inactivating glycogen synthase kinase 3 (GSK3), thereby inactivating complex IV and increasing intracellular ROS. In the present study, we identified protein kinase C delta (PKCδ) as an upstream regulator of GSK3 inactivation in this mechanis...

journal_title：Free radical research

authors： Byun HO,Jung HJ,Kim MJ,Yoon G

更新日期：2014-09-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-p...

journal_title：Free radical research

authors： Wang H,Jenner AM,Lee CY,Shui G,Tang SY,Whiteman M,Wenk MR,Halliwell B

更新日期：2007-04-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various cells from L-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO includes oxidation to nitrate by oxyhaemoglobin in red blood cells and autoxidation in haemoglobin-free media to nitrite. Nitrate and ni...

journal_title：Free radical research

authors： Tsikas D

更新日期：2005-08-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS co...

journal_title：Free radical research

authors： Sheshadri P,Kumar A

更新日期：2016-01-01 00:00:00

abstract：:APE1/Ref-1, the mammalian ortholog of E. coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has dual role in controlling cellular response to oxidative stress. It is rate-limiting in repair of oxidative DNA damage including strand breaks and also has co-transc...

journal_title：Free radical research

authors： Fantini D,Vascotto C,Deganuto M,Bivi N,Gustincich S,Marcon G,Quadrifoglio F,Damante G,Bhakat KK,Mitra S,Tell G

更新日期：2008-01-01 00:00:00

abstract：:In order to elucidate the oxidative damage in rat brain caused by oxidative stress, regional changes in the levels of lipid peroxidation products and antioxidative defense systems in cerebral cortex and hippocampus, and in their synapses, which modulate learning and memory functions in the brain, were studied. When ra...

journal_title：Free radical research

authors： Onodera K,Omoi NO,Fukui K,Hayasaka T,Shinkai T,Suzuki S,Abe K,Urano S

更新日期：2003-04-01 00:00:00

abstract：:Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous...

journal_title：Free radical research

authors： Moldogazieva NT,Mokhosoev IM,Feldman NB,Lutsenko SV

更新日期：2018-05-01 00:00:00

abstract：:Peroxiredoxin 1 (PRDX1) is an antioxidant enzyme that, when secreted, can act as a proinflammatory signal. Here we studied the regulation of intracellular PRDX1 by lipopolysaccharide (LPS) and interferon-gamma (IFN-γ) in the RAW 264.7 mouse macrophage cell line. While LPS or IFN-γ alone did not affect PRDX1 protein le...

journal_title：Free radical research

authors： Ingram S,Mengozzi M,Heikal L,Mullen L,Ghezzi P

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...

journal_title：Free radical research

authors： Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue M

更新日期：2004-04-01 00:00:00

abstract：:In this study, three rapid assay techniques for the determination of glutathione, one enzymatic, one fluorometric and one newly patented colorimetric method, were compared by measuring reduced (GSH) and oxidized (GSSG) glutathione in guinea-pig heart and liver. The HPLC technique was used as a standard, since it is co...

journal_title：Free radical research

authors： Floreani M,Petrone M,Debetto P,Palatini P

更新日期：1997-05-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:The antioxidative activity of hydroxylamines was evaluated for the oxidation of tetralin at 61 degrees C and linoleic acid micelles in an aqueous dispersion at 37 degrees C, induced by an azo initiator. The antioxidative efficacy of the hydroxylamines for the oxidation of tetralin was smaller than that of alpha-tocoph...

journal_title：Free radical research

authors： Nishiyama T,Tamekuni H,Tachibana T,Kitamura H,Saito S

更新日期：2001-12-01 00:00:00

abstract：:Formation of the alpha-hydroxyethyl radical (CH3 degree CHOH) has already been extensively demonstrated after ethanol metabolism in the liver. Despite favourable conditions, this formation in the brain has remained speculative since there is no direct experimental evidence in intact brain cells. In this preliminary st...

journal_title：Free radical research

authors： Gonthier B,Eysseric H,Soubeyran A,Daveloose D,Saxod R,Barret L

更新日期：1997-12-01 00:00:00

abstract：:Many epidemiological data indicate the presence of a strong familial component of longevity that is largely determined by genetics, and a number of possible associations between longevity and allelic variants of genes have been described. A breakthrough strategy to get insight into the genetics of longevity is the stu...

journal_title：Free radical research

authors： Salvioli S,Olivieri F,Marchegiani F,Cardelli M,Santoro A,Bellavista E,Mishto M,Invidia L,Capri M,Valensin S,Sevini F,Cevenini E,Celani L,Lescai F,Gonos E,Caruso C,Paolisso G,De Benedictis G,Monti D,Franceschi C

更新日期：2006-12-01 00:00:00

abstract：:An increasing incidence of unresponsiveness to antimonials in Leishmaniasis has led to identification of plant-derived anti-leishmanial compounds like Artemisinin. Since iron-mediated generation of free radicals sustains the anti-malarial activity of Artemisinin, this study investigated whether similar mechanisms acco...

journal_title：Free radical research

authors： Sen R,Saha P,Sarkar A,Ganguly S,Chatterjee M

更新日期：2010-11-01 00:00:00

abstract：:Reactive oxygen species (ROS) released from polymorphonuclear leukocytes and macrophages could cause DNA damage, but also induce cell death. Therefore inhibition of cell death must be an important issue for accumulation of genetic changes in lymphoid cells in inflammatory foci. Scavengers in the post culture medium of...

journal_title：Free radical research

authors： Miwa H,Fujii J,Kanno H,Taniguchi N,Aozasa K

更新日期：2000-07-01 00:00:00

abstract：:Involvement of oxidative stress is implicated in the progression of complication of diabetes mellitus. With respect to heart diseases, we have studied role of oxidative stress/antioxidants using rats treated with streptozotocin to induce diabetes (DM). Hemodynamic and echocardiographic measurements showed thickening o...

journal_title：Free radical research

authors： Doi K,Sawada F,Toda G,Yamachika S,Seto S,Urata Y,Ihara Y,Sakata N,Taniguchi N,Kondo T,Yano K

更新日期：2001-03-01 00:00:00

abstract：:Identification of free radicals was performed for the reaction mixtures of autoxidized 1,2-dilinoleoylphosphatidylcholine (DLPC) with ferrous ions (or DLPC hydroperoxide with ferrous ions) and of DLPC with soybean lipoxygenase using electron spin resonance (ESR), high performance liquid chromatography (HPLC)--ESR and ...

journal_title：Free radical research

authors： Kumamoto K,Hirai T,Kishioka S,Iwahashi H

更新日期：2005-09-01 00:00:00

abstract：:7,8-Dihydroneopterin protects cells intracellularly from oxidative stress-induced death, but its mode of transport across the cell membrane is unknown. Nucleosides, such as guanosine, are transported via nucleoside transporters of the equilibrative and concentrative forms. Therefore, the objective of this study was to...

journal_title：Free radical research

authors： Janmale TV,Lindsay A,Gieseg SP

更新日期：2020-05-01 00:00:00

abstract：:The production of reactive oxygen species, including hydrogen peroxide (H(2)O(2)), is increased in diseased blood vessels. Although H(2)O(2) leads to impairment of the nitric oxide (NO)/soluble guanylate cyclase (sGC)/cGMP signaling pathway, it is not clear whether this reactive molecule affects the redox state of sGC...

journal_title：Free radical research

authors： Tawa M,Shimosato T,Iwasaki H,Imamura T,Okamura T

更新日期：2015-01-01 00:00:00

abstract：:To define the molecular mechanism(s) of carvedilol inhibition of lipid peroxidation we have utilized model systems that allow us to study the different reactions involved in this complex process. Carvedilol inhibits the peroxidation of sonicated phosphatidylcholine liposomes triggered by FeCl2 addition whereas atenolo...

journal_title：Free radical research

authors： Tadolini B,Franconi F

更新日期：1998-11-01 00:00:00