Abstract:
:The increasing knowledge on the participation of free radicals in many diverse clinical and pathological conditions, has consequently expanded the search for new and versatile antioxidants aimed at combating oxidative stress. Our interest in this field concerns aromatic indolinonic aminoxyls (nitroxides) which efficiently react with alkoxyl, peroxyl, aminyl, arylthiyl and alkyl radicals to give non-paramagnetic species. This prompted us to test their antioxidant activity on different biological systems exposed to free radical-induced oxidative stress and the results obtained so far have been very promising. However little is known about their behaviour towards superoxide and hydroxyl radicals. Here, we report on the reactivity of an indolinonic aminoxyl, with the two above mentioned radicals using hypoxanthine/xanthine oxidase and potassium superoxide for generating the former and the Fenton reagent for the latter. Besides performing the deoxyribose assay for studying the reaction of the aminoxyl with hydroxyl radical and monitoring spectral changes of the aminoxyl in the presence of superoxide radical, macroscale reactions were performed in both cases and the products of the reactions isolated and identified. The EPR technique was used in this study to help elucidate the data obtained. The results show that this compound efficiently reacts with both hydroxyl and superoxide radicals and furthermore, it is capable of maintaining iron ions in its oxidized form. The results thus contribute to increasing the knowledge on the reactivity of indolinonic aminoxyls towards free radical species and as a consequence, these compounds and/or other aminoxyl derivatives, may be considered as complementary, and sometimes alternative sources for combating oxidative damage.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Damiani E,Carloni P,Stipa P,Greci Ldoi
10.1080/10715769900301621keywords:
subject
Has Abstractpub_date
1999-08-01 00:00:00pages
113-21issue
2eissn
1071-5762issn
1029-2470journal_volume
31pub_type
杂志文章abstract::This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500385699
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abstract::Recent findings have suggested that oxidative damage might contribute to the cytotoxicity and carcinogenicity of aflatoxin B1 (AFB1). Salvia miltiorrhiza (Sm), a herbal plant that has been used extensively in traditional Chinese medicine for treating cardiovascular and liver diseases, is believed to have some antioxid...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900301131
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doi:10.1080/10715760802691455
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576021000006626
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abstract::Carotenoids scavenge simple lipid-like alkylperoxyl radicals. However, the rate constant is too low to be determined directly and the mechanism is likewise not known with certainty [Mortensen, A. and Skibsted, L.H. (1998) FEBS Lett. 426, 392-396]. It is demonstrated that carotenoids react with peroxyl radicals only sl...
journal_title:Free radical research
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doi:10.1080/10715760290006501
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pub_type: 杂志文章
doi:10.3109/10715762.2010.536838
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1999-04-01 00:00:00
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journal_title:Free radical research
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journal_title:Free radical research
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doi:10.1080/10715760701534368
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journal_title:Free radical research
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doi:10.1080/10715769900300791
更新日期:1999-09-01 00:00:00
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journal_title:Free radical research
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doi:10.3109/10715769709097838
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doi:10.3109/10715769709097848
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pub_type: 杂志文章,评审
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