Impairment of calcium ATPases by high glucose and potential pharmacological protection.

abstract：:A small part of cellular iron, usually called 'labile iron pool' (LIP), is not securely stored and has the potential to catalyse the formation of highly reactive oxygen species. The present work estimated LIP levels in human white cells by using the analytical power of flow cytometry. The method relies essentially on ...

journal_title：Free radical research

authors： Doulias PT,Vlachou C,Boudouri C,Kanavaros P,Siamopoulos KC,Galaris D

更新日期：2008-03-01 00:00:00

abstract：:Creatol (CTL) is a product resulting from the reaction of creatinine (Cr) with the hydroxyl radical and is identified as a precursor of methylguanidine (MG), a uremic toxin. In this study, we investigated serum CTL levels together with those of Cr and MG in 66 patients who were on maintenance hemodialysis (HD). Prior ...

journal_title：Free radical research

authors： Tomida C,Aoyagi K,Nagase S,Gotoh M,Yamagata K,Takemura K,Koyama A

更新日期：2000-01-01 00:00:00

abstract：:Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...

journal_title：Free radical research

authors： Hiramoto K,Tomiyama S,Kikugawa K

更新日期：1999-01-01 00:00:00

abstract：:Various lines of evidence indicate that an important part in the pathogenesis of atherosclerosis is the modification of the plasma low-density lipoproteins (LDLs). A large number of pro-inflammatory and pro-atherogenic properties have been ascribed to the oxidatively modified LDLs and their components. There is consid...

journal_title：Free radical research

authors： Uchida K

更新日期：2015-01-01 00:00:00

abstract：:Intracellular levels of H2O2 in BHK-21 cells are not static but decline progressively with cell growth. Exposure of cells to inhibitors of catalase, or glutathione peroxidase, not only diminishes this decline but also depresses rates of cell proliferation, suggesting important growth regulatory roles for those antioxi...

journal_title：Free radical research

authors： Burdon RH,Alliangana D,Gill V

更新日期：1995-11-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) is a neurotoxin to produce an animal model of Parkinson's disease. 6-OHDA increased the formation of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), a biomarker of oxidatively damaged DNA, and induced apoptosis in human neuroblastoma SH-SY5Y cells. Iron or copper chelators inhibited 6-OHDA-i...

journal_title：Free radical research

authors： Kobayashi H,Oikawa S,Umemura S,Hirosawa I,Kawanishi S

更新日期：2008-07-01 00:00:00

abstract：:In human organism, the gaseous radical molecule nitric oxide (NO) is produced in various cells from L-arginine by the catalytic action of NO synthases (NOS). The metabolic fate of NO includes oxidation to nitrate by oxyhaemoglobin in red blood cells and autoxidation in haemoglobin-free media to nitrite. Nitrate and ni...

journal_title：Free radical research

authors： Tsikas D

更新日期：2005-08-01 00:00:00

abstract：:Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...

journal_title：Free radical research

authors： Dorigan de Matos Furlanetto AL,Valente C,Martinez GR,Merlin Rocha ME,Maurer JBB,Cadena SMSC

更新日期：2019-01-01 00:00:00

abstract：:To determine effect of nitric oxide (NO) on cellular glutathione peroxidase (GPX) level in living cells, we measured the activity, protein and mRNA of GPX in rat kidney (KNRK) cells under a high NO condition. Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ...

journal_title：Free radical research

authors： Dobashi K,Asayama K,Nakane T,Kodera K,Hayashibe H,Nakazawa S

更新日期：2001-09-01 00:00:00

abstract：:Extensive research in the past decade has revealed cancer to be a multigenic disease caused by perturbation of multiple cell signalling pathways and dysregulation of numerous gene products, all of which have been linked to inflammation. It is also becoming evident that various lifestyle factors, such as tobacco and al...

journal_title：Free radical research

authors： Sung B,Prasad S,Yadav VR,Lavasanifar A,Aggarwal BB

更新日期：2011-08-01 00:00:00

abstract：:Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...

journal_title：Free radical research

authors： Zusterzeel PL,Mulder TP,Peters WH,Wiseman SA,Steegers EA

更新日期：2000-11-01 00:00:00

abstract：:Glycation of proteins or other biomolecules and their further long-term degradation result in the formation of advanced glycation end products, AGEs. AGEs and other ligands interact with their receptors, RAGEs, localized to a variety of tissues, but mainly in endothelium and vascular wall cells. This interaction trigg...

journal_title：Free radical research

authors： Guedes-Martins L,Matos L,Soares A,Silva E,Almeida H

更新日期：2013-08-01 00:00:00

abstract：:Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk facto...

journal_title：Free radical research

authors： Scicchitano P,Cortese F,Gesualdo M,De Palo M,Massari F,Giordano P,Ciccone MM

更新日期：2019-06-01 00:00:00

abstract：:Reactive oxygen species (ROS) are critically important chemical intermediates in biological studies, due to their multiple physiologically essential functions and their often pathologically deleterious effects. Consequently, it is vital that their presence in biological samples has to be quantifiable. However, their h...

journal_title：Free radical research

authors： Chen X,Zhong Z,Xu Z,Chen L,Wang Y

更新日期：2010-06-01 00:00:00

abstract：:Antioxidants are important species which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. A variety of free radical-scavenging antioxidants exist within the body many of which are derived from dietary sources. There is currently much interest in the antioxidant role ...

journal_title：Free radical research

authors： Robinson EE,Maxwell SR,Thorpe GH

更新日期：1997-03-01 00:00:00

abstract：:Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...

journal_title：Free radical research

authors： Morena M,Patrier L,Jaussent I,Bargnoux AS,Dupuy AM,Badiou S,Leray-Moragues H,Klouche K,Canaud B,Cristol JP

更新日期：2011-06-01 00:00:00

abstract：:α-Tocopherol (a form of vitamin E) is a fat-soluble vitamin that can prevent lipid peroxidation of cell membranes. This antioxidant activity of α-tocopherol can help to prevent cardiovascular disease, atherosclerosis and cancer. We investigated the α-tocopherol level and the expression of α-tocopherol transfer protein...

journal_title：Free radical research

authors： Misaki K,Takitani K,Ogihara T,Inoue A,Kawakami C,Kuno T,Kawamura N,Miyake M,Nakagawa T,Tamai H

更新日期：2003-01-01 00:00:00

abstract：:The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by ge...

journal_title：Free radical research

authors： Riemersma RA,Wilson R,Payne JA,Shepherd MJ

更新日期：2003-03-01 00:00:00

abstract：:Gastric inflammation is a highly complex biochemical protective response to cellular/tissue injury. When this process occurs in an uncontrolled manner, the result is excessive cellular/tissue damage that results chronic inflammation and destruction of normal tissue. Current evidence suggests that Helicobacter pylori (...

journal_title：Free radical research

authors： Yoshikawa T,Naito Y

更新日期：2000-12-01 00:00:00

abstract：:The antioxidant properties of protoporphyrin IX and related tetrapyrroles are poorly characterized. Therefore, eight tetrapyrroles, five of which are produced in vivo, were tested to assess their antioxidant capacities in the Salmonella reverse mutation, TEAC, FRAP and ORAC assays. Tertiary-butyl hydroperoxide (tert-B...

journal_title：Free radical research

authors： Mölzer C,Huber H,Steyrer A,Ziesel G,Ertl A,Plavotic A,Wallner M,Bulmer AC,Wagner KH

更新日期：2012-11-01 00:00:00

abstract：:The purpose of this double clinical study was (1) to evaluate the effect of one single intake (300 ml) of red wine (RW) on the plasma antioxidant capacity (pAOC) and plasma phenolics over the 24-h time period following the intake, and (2) to compare the long-term effects of daily intakes (250 ml/d) of RW, white wine (...

journal_title：Free radical research

authors： Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

更新日期：2003-09-01 00:00:00

abstract：:Epidemiologically, a high-carotenoid intake via a fruit- and vegetable-rich diet is associated with a decreased risk of various forms of cancer. The mechanisms by which carotenoids exert this protective effect are controversial. In this study, we examined the potency of a range of carotenoids commonly found in human p...

journal_title：Free radical research

authors： Müller K,Carpenter KL,Challis IR,Skepper JN,Arends MJ

更新日期：2002-07-01 00:00:00

abstract：:The effects of inorganic phosphate (Pi), the main intracellular membrane permeable anion capable of altering mitochondrial pH gradients (Delta pH), were measured on mitochondrial H2O2 release. As expected, Pi decreased Delta pH and increased the electric membrane potential (Delta Psi). Mitochondrial H2O2 release was s...

journal_title：Free radical research

authors： Oliveira GA,Kowaltowski AJ

更新日期：2004-10-01 00:00:00

abstract：:Oxidized low density lipoprotein (LDL) has a major impact in the development of atherosclerosis. Risk for oxidative modification of LDL is usually determined indirectly by measuring the capability of LDL to resist radical insult. We compared three different methods quantifying the antioxidative capacity of LDL ex vivo...

journal_title：Free radical research

authors： Malminiemi K,Palomäki A,Malminiemi O

更新日期：2000-11-01 00:00:00

abstract：:The turning point between apoptosis and necrosis induced by hydrogen peroxide (H2O2) have been investigated using human T-lymphoma Jurkat cells. Cells treated with 50 microM H2O2 exhibited caspase-9 and caspase-3 activation, finally leading to apoptotic cell death. Treatment with 500 microM H2O2 did not exhibit caspas...

journal_title：Free radical research

authors： Saito Y,Nishio K,Ogawa Y,Kimata J,Kinumi T,Yoshida Y,Noguchi N,Niki E

更新日期：2006-06-01 00:00:00

abstract：:It is well known that reperfusion damage of ischemic myocardium may be attributed to alterations in the antioxidant defense system against free radical aggression. In addition, the degree of myocardial damage may depend on the duration and severity of ischemia that precedes reperfusion. We carried out serial ischemic ...

journal_title：Free radical research

authors： Porreca E,Del Boccio G,Lapenna D,Di Febbo C,Pennelli A,Cipollone F,Di Ilio C,Cuccurullo F

更新日期：1994-03-01 00:00:00

abstract：:The bioactive flavonoid baicalein has been shown to have radioprotective activity, although the molecular mechanism is poorly understood in vivo. C57BL/6 mice were irradiated with X-rays (15 Gy) with and without baicalein treatment (5 mg/kg/day). Irradiation groups showed an increase of NF-κB-mediated inflammatory fac...

journal_title：Free radical research

authors： Lee EK,Kim JM,Choi J,Jung KJ,Kim DH,Chung SW,Ha YM,Yu BP,Chung HY

更新日期：2011-05-01 00:00:00

abstract：:Polystyrene supported fluorinated cyclic nitrone spin-traps: Resin-2-HFDMPO (2-hydroxymethyl-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole-1-oxide) and Resin-2-PFDMPO (2-(3-hydroxypropyl)-2-methyl-5-(trifluoromethyl)-3,4-dihydro-2H-pyrrole 1-oxide) containing a trifluoromethyl pyrroline-N-oxide core were develop...

journal_title：Free radical research

authors： Earla A,Walter ED,Braslau R

更新日期：2019-12-01 00:00:00

abstract：:The aim of this study was to investigate the effect of HDL oxidation on PON1 paraoxonase activity. Also, we were interested in investigating the mechanism by which PON1 could be inactivated and the correlation between its enzymatic activity and the antioxidant properties of HDL. Three different oxidation systems were ...

journal_title：Free radical research

authors： Jaouad L,Milochevitch C,Khalil A

更新日期：2003-01-01 00:00:00