Abstract:
:Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk factors explain the higher CBD incidence in the general population, as they are able to anticipate the clinical expression of atherosclerosis. These risk factors are effectively able to promote endothelial dysfunction which is the premise for the early, clinical expression of atherosclerosis. The mechanisms by which risk factors can influence the occurrence of CBD are different and not fully understood. The inflammatory background of atherosclerosis can explain a great part of it. In particular, the oxidative stress may promote the development of vascular lesions by negatively influencing biochemical cellular processes of the endothelium, thus predisposing the vascular tree to morphological and functional damages. The aim of this narrative review is to evaluate the role of endothelial dysfunction and oxidative stress in CBD development.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Scicchitano P,Cortese F,Gesualdo M,De Palo M,Massari F,Giordano P,Ciccone MMdoi
10.1080/10715762.2019.1620939subject
Has Abstractpub_date
2019-06-01 00:00:00pages
579-595issue
6eissn
1071-5762issn
1029-2470journal_volume
53pub_type
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