Malondialdehyde and 4-hydroxy-2-nonenal in plant tissue cultures: LC-MS determination of 2,4-dinitrophenylhydrazone derivatives.

abstract：:Glucose at pathophysiological concentrations was able to accelerate copper-induced oxidation of isolated low-density lipoprotein (LDL) and whole serum. The efficiency of glucose was favored under the following circumstances: (a) when LDL oxidation was induced by low copper concentration, (b) when LDL was partly oxidiz...

journal_title：Free radical research

authors： Leoni V,Albertini R,Passi A,Abuja PM,Borroni P,D'Eril GM,De Luca G

更新日期：2002-05-01 00:00:00

abstract：:The glutathione system in epidermal cells of Allium cepa L. was measured by a quantitative image analysis method, using histochemical staining by monochlorobimane. Blockage of thiol groups with N-ethylmaleimide decreased fluorescence to a small rest fluorescence of maximum 5%. Pre-treatment with dithiothreitol increas...

journal_title：Free radical research

authors： Müller M,Tausz M,Wonisch A,Grill D

更新日期：1999-12-01 00:00:00

abstract：:Oxygen radical generating systems, namely, Cu(II)/ H2O2, Cu(II)/ascorbate, Cu(II)/NAD(P)H, Cu(II)/ H2O2/catecholamine and Cu(II)/H2O2/SH-compounds irreversibly inhibited yeast glutathione reductase (GR) but Cu(II)/H2O2 enhanced the enzyme diaphorase activity. The time course of GR inactivation by Cu(II)/H2O2 dependent...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1997-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS co...

journal_title：Free radical research

authors： Sheshadri P,Kumar A

更新日期：2016-01-01 00:00:00

abstract：:Peroxynitrite anion is a reactive and short-lived species and its formation in vivo has been implicated in several human diseases. In view of the potential usefulness of compounds that can protect against peroxynitrite or their reactive intermediates, a study focused on flavonoid compounds was carried out. Since the r...

journal_title：Free radical research

authors： Santos MR,Mira L

更新日期：2004-09-01 00:00:00

abstract：:Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...

journal_title：Free radical research

authors： Peerapanyasut W,Thamprasert K,Wongmekiat O

更新日期：2014-02-01 00:00:00

abstract：:Silver nanoparticles (AgNPs) are the most widely used nanomaterials as antimicrobial agents. AgNPs have been shown to inhibit the growth of and induce apoptosis-like death in Escherichia coli. However, the precise mechanism of AgNPs-induced apoptosis-like death and association with DNA damage-inducible protein F (dinF...

journal_title：Free radical research

authors： Kim S,Lee DG

更新日期：2021-01-06 00:00:00

abstract：:Liver microsomal functions related to xenobiotic biotransformation and free radical production were studied in control rats and in animals subjected to L-3,3',5-triiodothyronine (T3) and/or lindane administration as possible mechanisms contributing to oxidative stress, in relation to the activity of enzymes (superoxid...

journal_title：Free radical research

authors： Simon Giavarotti KA,Rodrigues L,Rodrigues T,Junqueira VB,Videla LA

更新日期：1998-07-01 00:00:00

abstract：:Thioredoxin-1 (TRX) is a redox-active protein with anti-inflammatory effects. This study investigated the optimal delivery method and the mechanisms of recombinant human TRX (rhTRX) to suppress neutrophil recruitment in a rat bleomycin (BLM)-induced sustained acute lung injury model. In male Wister rats intratracheall...

journal_title：Free radical research

authors： Nakamura T,Hoshino Y,Yamada A,Teratani A,Furukawa S,Okuyama H,Ueda S,Wada H,Yodoi J,Nakamura H

更新日期：2007-10-01 00:00:00

abstract：:5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO), a new cyclic DEPMPO-type nitrone was evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. CYPMPO is colorless crystalline and freely soluble in water. Both the solid and diluted aqueous solution did not dev...

journal_title：Free radical research

authors： Kamibayashi M,Oowada S,Kameda H,Okada T,Inanami O,Ohta S,Ozawa T,Makino K,Kotake Y

更新日期：2006-11-01 00:00:00

abstract：:The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this ...

journal_title：Free radical research

authors： Tartaro Bujak I,Mihaljević B,Ferreri C,Chatgilialoglu C

更新日期：2016-11-01 00:00:00

abstract：:Approaching living systems, aqueous solutions are appropriate to characterize antioxidants, whereas the frequently used standard 1,1-diphenyl-2-picrylhydrazyl (DPPH) is insoluble in water. Therefore, mixed water-ethanol solvents were investigated using the electron paramagnetic resonance (EPR) spectroscopy. Two forms ...

journal_title：Free radical research

authors： Stasko A,Brezová V,Biskupic S,Misík V

更新日期：2007-04-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:This work describes the synthesis and characterisation of some novel hybrid molecules which contains in the same molecule a free radical moiety of hydrazyl type and a spin-trap moiety of nitrone type. The new compounds synthesized have multiple and easy to follow spectroscopic properties, making them useful as sensors...

journal_title：Free radical research

authors： Ionita P

更新日期：2006-01-01 00:00:00

abstract：:The ubiquitin-proteasome system (UPS) and autophagy are two major intracellular proteolytic systems that are closely associated with each other. Because UPS and autophagy are involved in the clearance of oxidised and/or aggregated proteins, it would be logical to assume that alterations in proteolysis would accompany ...

journal_title：Free radical research

authors： Homma T,Fujii J

更新日期：2020-04-20 00:00:00

abstract：:Various lines of evidence indicate that an important part in the pathogenesis of atherosclerosis is the modification of the plasma low-density lipoproteins (LDLs). A large number of pro-inflammatory and pro-atherogenic properties have been ascribed to the oxidatively modified LDLs and their components. There is consid...

journal_title：Free radical research

authors： Uchida K

更新日期：2015-01-01 00:00:00

abstract：:The potential of free radical formation in serum of beta-thalassemia/Hb E patients receiving a single oral dose of 25 mg/kg body weight of deferiprone, a bidentate orally active iron chelator, was evaluated using EPR/spin trapping technique. In the presence of ascorbic acid and tert-butylhydroperoxide, EPR signals of ...

journal_title：Free radical research

authors： Jirasomprasert T,Morales NP,Limenta LM,Sirijaroonwong S,Yamanont P,Wilairat P,Fucharoen S,Chantharaksri U

更新日期：2009-05-01 00:00:00

abstract：:The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated. Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats. Maleate-induced renal injury included increase in renal v...

journal_title：Free radical research

authors： Tapia E,Sánchez-Lozada LG,García-Niño WR,García E,Cerecedo A,García-Arroyo FE,Osorio H,Arellano A,Cristóbal-García M,Loredo ML,Molina-Jijón E,Hernández-Damián J,Negrette-Guzmán M,Zazueta C,Huerta-Yepez S,Reyes JL,Madero M

更新日期：2014-11-01 00:00:00

abstract：RATIONALE:The oxidative state has been implicated in the signaling of various vasomotor functions, yet its role regarding the vasomotor action of insulin is less known. OBJECTIVE:To investigate the insulin-evoked relaxations of consecutive arterial segments of different oxidative state and the role of extracellular si...

journal_title：Free radical research

authors： Szijártó IA,Molnár GA,Mikolás E,Fisi V,Laczy B,Gollasch M,Koller A,Wittmann I

更新日期：2014-07-01 00:00:00

abstract：:Exposure of dry powder forms of the drugs nitrendipine, nifedipine, felodipine, and nimodipine to gamma-radiation results in the formation of free radicals detected by electron paramagnetic resonance (EPR) spectroscopy. The four structurally related drugs show qualitatively identical EPR spectral features in terms of ...

journal_title：Free radical research

authors： Taiwo FA,Patterson LH,Jaroszkiewicz E,Marciniec B,Ogrodowczyk M

更新日期：1999-09-01 00:00:00

abstract：:Dietary flavonoids, present in different amount in foods, are associated with the prevention of hypertension, but little is known about the interactions between them. The aim of this study was to explore the effect of quercetin (Q), catechin (C) and the mixture, on Angiotensin II (AngII)-induced redox-dependent signal...

journal_title：Free radical research

authors： Redondo A,Estrella N,Lorenzo AG,Cruzado M,Castro C

更新日期：2012-05-01 00:00:00

abstract：:It has previously been reported that the globular form of adiponectin (gAd), mature adipocyte-derived cytokine, induced generation of reactive oxygen species (ROS) and nitric oxide (NO) in the murine macrophage cell line RAW 264. This study investigated whether diacylglycerol kinases (DGKs), enzymes functioning in sub...

journal_title：Free radical research

authors： Kamio N,Akifusa S,Yamashita Y

更新日期：2011-03-01 00:00:00

abstract：:Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...

journal_title：Free radical research

authors： Zhang H,Zheng RL

更新日期：1996-04-01 00:00:00

abstract：:Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

journal_title：Free radical research

authors： Dutta A,Gupta ML,Verma S

更新日期：2018-01-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a lung disease caused by an inflammatory response to various inhaled toxins, especially cigarette smoke. Reactive oxygen species (ROS) and epigenetic abnormality are intimately related to the pathology of COPD, and the overproduction of ROS results in a decrease of histo...

journal_title：Free radical research

authors： Chikuma K,Arima K,Asaba Y,Kubota R,Asayama S,Sato K,Kawakami H

更新日期：2019-12-06 00:00:00

abstract：:It has been observed that H9c2 cardiac cells cultured in physiologic solutions exhibit delayed cell death after repeated medium replacements, of which the cause was the relatively mild osmotic challenges during the renewal of the culture medium. Interestingly, the cell damage was associated with altered intracellular ...

journal_title：Free radical research

authors： Lee JW,Ko YE,Lee IH,Lee HK,Kim HW,Kim YH

更新日期：2009-03-01 00:00:00

abstract：:Oxidative reactions are thought to play a role in the inflammatory condition called fatty liver. It is unclear whether oxidized lipoprotein lipids or proteins are associated with future fatty liver. In the Cardiovascular Risk in Young Finns Study, we determined the circulating levels of LDL and HDL oxidized lipids and...

journal_title：Free radical research

authors： Kaikkonen JE,Kresanov P,Ahotupa M,Jula A,Mikkilä V,Viikari JS,Juonala M,Hutri-Kähönen N,Kähönen M,Lehtimäki T,Kangas AJ,Soininen P,Ala-Korpela M,Raitakari OT

更新日期：2016-01-01 00:00:00

abstract：:Rabbits were fed a diet containing 1% cholesterol for 8 weeks and the levels of iron and oxidized lipids in liver analysed using atomic absorption spectroscopy and gas chromatography-mass spectrometry. A non-significant trend to an increase in iron level, but significant increases in the lipid peroxidation products, F...

journal_title：Free radical research

authors： Ong WY,Jenner AM,Pan N,Ong CN,Halliwell B

更新日期：2009-03-01 00:00:00

abstract：:G72 has been characterised as a susceptibility gene that can have wide-ranging effects in a number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is a potential serum biomarker for schizophrenia. Previous transcriptomic and biochemical studies have indicated th...

journal_title：Free radical research

authors： Wang M,Saw HP,Cui FF,Lin SY,Chang HT,Chiu CD

更新日期：2018-09-01 00:00:00

abstract：:Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...

journal_title：Free radical research

authors： Funahashi S,Okazaki Y,Akatsuka S,Takahashi T,Sakumi K,Nakabeppu Y,Toyokuni S

更新日期：2020-03-01 00:00:00