Abstract:
:The biomimetic model of micelles of linoleic acid containing 2-mercaptoethanol and the antioxidant was examined under gamma irradiation up to 400 Gy in aerobic or deoxygenated conditions where thiyl radicals are the main reactive species. Lipid peroxidation was retarded by ascorbic acid and α-tocopherol, whereas this process was strongly inhibited by resveratrol as effectively as the ascorbic acid/α-tocopherol mixture. Furthermore, antioxidants have a much stronger inhibitory effect on the peroxidation in the presence of 2-mercaptoethanol, and at the same time show protective properties of the double bond, decreasing the cis-trans isomerization. Under anaerobic conditions, cis-trans isomerization occurred and antioxidants efficiency increased along the series: resveratrol < α-tocopherol < ascorbic acid. This result is explained taking into account the double bond localization in the hydrophobic core of the micelle and the need of co-localization of the antioxidant in order to get an anti-isomerizing activity and protection of the natural lipid geometry.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Tartaro Bujak I,Mihaljević B,Ferreri C,Chatgilialoglu Cdoi
10.1080/10715762.2016.1231401subject
Has Abstractpub_date
2016-11-01 00:00:00pages
S18-S23issue
sup1eissn
1071-5762issn
1029-2470journal_volume
50pub_type
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