Fruit and vegetable and fried food consumption and 3-(2-deoxy-β-D-erythro-pentafuranosyl)pyrimido[1,2-α] purin-10(3H)-one deoxyguanosine adduct formation.

abstract：:Neopterin and its reduced form, 7,8 dihydroneopterin are pteridines released from macrophages and monocytes when stimulated with interferon gamma in vivo. The function of this response is unknown though there is an enormous amount of information available on the use of these compounds as clinical markers of monocyte/m...

journal_title：Free radical research

authors： Gieseg SP,Reibnegger G,Wachter H,Esterbauer H

更新日期：1995-08-01 00:00:00

abstract：:Using a novel phosphorylated spin trap, 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO), an analogue of the commonly used spin trap 5,5'-dimethyl-1-pyrroline N-oxide (DMPO), we have investigated the production of oxygen radical species under illumination of thylakoids from wheat (Triticum durum Desf cv. O...

journal_title：Free radical research

authors： Sgherri CL,Pinzino C,Samaritani E,Navari-Izzo F

更新日期：1999-12-01 00:00:00

abstract：:The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or doubl...

journal_title：Free radical research

authors： Rytter E,Johansson C,Vessby B,Sjödin A,Möller L,Akesson B,Basu S

更新日期：2010-05-01 00:00:00

abstract：:Copper Fenton systems (Cu(II)/H2O2 and Cu(II)/Asc) inactivated the lipoamide reductase and enhanced the diaphorase activity of pig-heart lipoamide dehydrogenase (LADH). Cupric ions alone were less effective. As a result of Cu(II)/H2O2 treatment, the number of titrated thiols in LADH decreased from 6 to 1 per subunit. ...

journal_title：Free radical research

authors： Gutierrez-Correa J,Stoppani AO

更新日期：1995-03-01 00:00:00

abstract：:It has been reported that haem oxygenase-1 (Hmox1) induction attenuates neointimal thickening. Here we further investigated the potential mechanisms regulating this important pathological process. We revealed that histone deacetylase 2 (HDAC2) was induced following Hmox1 induction under 1% oxygen treatment and this in...

journal_title：Free radical research

authors： Ni J,Yang W,Shen W,Zhang R

更新日期：2018-10-01 00:00:00

abstract：:We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene displayed dose-dependent ...

journal_title：Free radical research

authors： Jin YS,Lee MJ,Han W,Heo SI,Sohn SI,Wang MH

更新日期：2006-09-01 00:00:00

abstract：:Curcumin is a polyphenol derived from the plant Curcuma longa that induces apoptotic cell death in malignant cancer cell lines. It has been shown previously that mitochondrial NADP(+)-dependent isocitrate dehydrogenase (IDPm) plays an essential role in defense against oxidative stress by supplying NADPH for antioxidan...

journal_title：Free radical research

authors： Jung KH,Park JW

更新日期：2011-04-01 00:00:00

abstract：:The aim of this study was to test the hypothesis that pulmonary inflammation and emphysema induced by cadmium (Cd) inhalation are associated with pulmonary oxidative stress. Two groups of Sprague Dawley rats were used: one vehicle-exposed group undergoing inhalation of NaCl (0.9%, n = 24) and one Cd-exposed group unde...

journal_title：Free radical research

authors： Kirschvink N,Martin N,Fievez L,Smith N,Marlin D,Gustin P

更新日期：2006-03-01 00:00:00

abstract：:We investigated the antioxidant and radical scavenging activity of polyphenolic isochromans. To assess the relation between structure and scavenging properties the natural occurring 1-(3'-methoxy-4'-hydroxy)phenyl-6,7-dihydroxy-isochroman (ISO-3, three OH groups) was compared with three newly synthesized derivatives t...

journal_title：Free radical research

authors： Lorenz P,Zeh M,Martens-Lobenhoffer J,Schmidt H,Wolf G,Horn TF

更新日期：2005-05-01 00:00:00

abstract：:It has been observed that H9c2 cardiac cells cultured in physiologic solutions exhibit delayed cell death after repeated medium replacements, of which the cause was the relatively mild osmotic challenges during the renewal of the culture medium. Interestingly, the cell damage was associated with altered intracellular ...

journal_title：Free radical research

authors： Lee JW,Ko YE,Lee IH,Lee HK,Kim HW,Kim YH

更新日期：2009-03-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is an essential cofactor of the electron transport gene as well as an important antioxidant, which is particularly effective within mitochondria. A number of prior studies have shown that it can exert efficacy in treating patients with known mitochondrial disorders. We investigated the potential u...

journal_title：Free radical research

authors： Beal MF

更新日期：2002-04-01 00:00:00

abstract：:There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation of the amyloid proteins associated with some of these diseases. Hydrog...

journal_title：Free radical research

authors： Tabner BJ,Turnbull S,King JE,Benson FE,El-Agnaf OM,Allsop D

更新日期：2006-07-01 00:00:00

abstract：:To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adj...

journal_title：Free radical research

authors： Chen K,Xie F,Liu S,Li G,Chen Y,Shi W,Hu H,Liu L,Yin D

更新日期：2011-05-01 00:00:00

abstract：:Over the last decades, oxidative stress has been described as a deleterious phenomenon contributing to numerous noncommunicable diseases such as cardiovascular disease, diabetes, and cancers. As many authors ascribed the healthy effect of fruit and vegetable consumption mainly to their antioxidant contents, it has bee...

journal_title：Free radical research

authors： Courraud J,Charnay C,Cristol JP,Berger J,Avallone S

更新日期：2013-12-01 00:00:00

abstract：:Reactive oxygen species (ROS) are important mediators of the cytotoxicity induced by the direct reaction of ionising radiation (IR) with all critical cellular components, such as proteins, lipids, and nucleic acids. The derived oxidative damage may propagate in exposed tissues in a dose- and spatiotemporal dependent m...

journal_title：Free radical research

authors： Pietraforte D,Paulicelli E,Patrono C,Gambardella L,Scorza G,Testa A,Fattibene P

更新日期：2018-04-01 00:00:00

abstract：:Several papers have claimed that mitochondria contain nitric oxide synthase (NOS) and make nitric oxide (NO*) in amounts sufficient to affect mitochondrial respiration. However, we found that the addition of L-arginine or the NOS inhibitor L-NMMA to intact rat liver mitochondria did not have any effect on the respirat...

journal_title：Free radical research

authors： Tay YM,Lim KS,Sheu FS,Jenner A,Whiteman M,Wong KP,Halliwell B

更新日期：2004-06-01 00:00:00

abstract：:Although the primary biological function of retinal photoreceptors is to absorb light and provide visual information, extensive exposure to intense light could increase the risk of phototoxic reactions mediated by products of rhodopsin bleaching that might accumulate in photoreceptor outer segments (POS). The phototox...

journal_title：Free radical research

authors： Olchawa M,Krzysztynska-Kuleta O,Duda M,Pawlak A,Pabisz P,Czuba-Pelech B,Sarna T

更新日期：2019-04-01 00:00:00

abstract：:The objective of this study was to elucidate the impact of physical activity during the growth period as well as on oxidative stress and antioxidative potential in adulthood. The experimental animals used were four-week old male Wistar rats, which were randomly divided into three groups. The exercise loads were as fol...

journal_title：Free radical research

authors： Lee S,Hashimoto J,Suzuki T,Satoh A

更新日期：2017-02-01 00:00:00

abstract：:Global gene expression profiles of livers from mice, fed diets differing in alpha-tocopherol content, were compared using DNA microarray technology. Three hundred and eighty nine genes were found to significantly differ in their expression level by a factor of 2 or higher between the high and the low alpha-tocopherol ...

journal_title：Free radical research

authors： Nell S,Bahtz R,Bossecker A,Kipp A,Landes N,Bumke-Vogt C,Halligan E,Lunec J,Brigelius-Flohé R

更新日期：2007-08-01 00:00:00

abstract：:Endothelial dysfunction is an early pathophysiological feature and independent predictor of poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an inverse association between dietary flavonoid consumption and mortality from cardiovascular diseases. In the present paper, we review th...

journal_title：Free radical research

authors： Perez-Vizcaino F,Duarte J,Andriantsitohaina R

更新日期：2006-10-01 00:00:00

abstract：:The turning point between apoptosis and necrosis induced by hydrogen peroxide (H2O2) have been investigated using human T-lymphoma Jurkat cells. Cells treated with 50 microM H2O2 exhibited caspase-9 and caspase-3 activation, finally leading to apoptotic cell death. Treatment with 500 microM H2O2 did not exhibit caspas...

journal_title：Free radical research

authors： Saito Y,Nishio K,Ogawa Y,Kimata J,Kinumi T,Yoshida Y,Noguchi N,Niki E

更新日期：2006-06-01 00:00:00

abstract：:Guanidinosuccinic acid (GSA) is noted for its nitric oxide (NO) mimicking actions such as vasodilatation and activation of the N-methyl-D-aspartate (NMDA) receptor. We have reported that GSA is the product of argininosuccinate (ASA) and some reactive oxygen species, mainly the hydroxyl radical. We tested for GSA synth...

journal_title：Free radical research

authors： Aoyagi K,Akiyama K,Shahrzad S,Tomida C,Hirayama A,Nagase S,Takemura K,Koyama A,Ohba S,Narita M

更新日期：1999-07-01 00:00:00

abstract：:Oxidative DNA modification has been implicated in development of certain cancers and 8-oxodG, the most abundant and mutagenic DNA modification, has for some time been considered a biomarker of this activity. Urinary excretion of 8-oxodG over 24h has been used to estimate the rate of damage to DNA, and animal studies h...

journal_title：Free radical research

authors： Poulsen HE,Loft S,Prieme H,Vistisen K,Lykkesfeldt J,Nyyssonen K,Salonen JT

更新日期：1998-12-01 00:00:00

abstract：:To solve the problems faced in clinical use of hypocrellins, a water-soluble preparation of Hypocrellin B (HB), HB-Triton X-100 (TX-100) micelles, was prepared. To evaluate the photodynamic activity, the free radicals (*OH and HB*-) and singlet oxygen (1O2) generated via photosensitization of the preparation in aqueou...

journal_title：Free radical research

authors： An H,Xie J,Zhao J,Li Z

更新日期：2003-10-01 00:00:00

abstract：:Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...

journal_title：Free radical research

authors： Funahashi S,Okazaki Y,Akatsuka S,Takahashi T,Sakumi K,Nakabeppu Y,Toyokuni S

更新日期：2020-03-01 00:00:00

abstract：:The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by ge...

journal_title：Free radical research

authors： Riemersma RA,Wilson R,Payne JA,Shepherd MJ

更新日期：2003-03-01 00:00:00

abstract：:Enhanced oxidative stress partly resulting from an over-production of superoxide anion (O(2)(•-)) represents a novel and particular risk factor in chronic kidney disease (CKD) patients. This study was therefore designed to evaluate O(2)(•-) determinants in this population. O(2)(•-) production was evaluated using chemi...

journal_title：Free radical research

authors： Morena M,Patrier L,Jaussent I,Bargnoux AS,Dupuy AM,Badiou S,Leray-Moragues H,Klouche K,Canaud B,Cristol JP

更新日期：2011-06-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) reproduces a multiple sclerosis (MS)-like experimental model. The main objective was to evaluate the effect of extremely low-frequency electromagnetic fields (EL-EMF) application, like a paradigm of transcranial magnetic stimulation (TMS) in the development of EAE. Rats ...

journal_title：Free radical research

authors： Medina-Fernandez FJ,Escribano BM,Agüera E,Aguilar-Luque M,Feijoo M,Luque E,Garcia-Maceira FI,Pascual-Leone A,Drucker-Colin R,Tunez I

更新日期：2017-05-01 00:00:00

abstract：:Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...

journal_title：Free radical research

authors： Hiramoto K,Tomiyama S,Kikugawa K

更新日期：1999-01-01 00:00:00

abstract：:Available data on the absorption, metabolism and pharmacokinetics of coenzyme Q10 (CoQ10) are reviewed in this paper. CoQ10 has a fundamental role in cellular bioenergetics. CoQ10 is also an important antioxidant. Because of its hydrophobicity and large molecular weight, absorption of dietary CoQ10 is slow and limited...

journal_title：Free radical research

authors： Bhagavan HN,Chopra RK

更新日期：2006-05-01 00:00:00