The effects of exercise load during development on oxidative stress levels and antioxidant potential in adulthood.

abstract：:Interactions between transition metal ions and polyphenols can result in complexation, redox or polymerization, but the relative importance of these reactions is unclear. The present paper reports results from the reaction of gallic acid (GA) with Cu(II) using electron paramagnetic resonance (EPR) and UV/visible spect...

journal_title：Free radical research

authors： Severino JF,Goodman BA,Reichenauer TG,Pirker KF

更新日期：2011-02-01 00:00:00

abstract：:Stichodactyla heliantus II (St II) is a haemolytic toxin whose activity depends of the characteristics of red blood cells (RBC). Among the factors that may tune the response of the RBC to the toxin activity stand the oxidative status of the cell. This study investigates how pre-oxidation of RBC modifies St II activity...

journal_title：Free radical research

authors： Celedón G,González G,Lissi E,Cerda T,Bascuñant D,Lepeley M,Pazos F,Lanio ME,Alvarez C

更新日期：2011-04-01 00:00:00

abstract：:The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...

journal_title：Free radical research

authors： Ferreri C,Golding BT,Jahn U,Ravanat JL

更新日期：2016-11-01 00:00:00

abstract：:The interaction between the hydrophobic indolinonic nitroxide radical, 1,2-dihydro-2-methyl-2-phenyl-3H-indole-3-one-1-oxyl and hydrophilic alpha-, beta- and gamma-cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins, random methyl-beta-cyclodextrin (RM-beta-...

journal_title：Free radical research

authors： Damiani E,Tursilli R,Casolari A,Astolfi P,Greci L,Scalia S

更新日期：2005-01-01 00:00:00

abstract：:To determine effect of nitric oxide (NO) on cellular glutathione peroxidase (GPX) level in living cells, we measured the activity, protein and mRNA of GPX in rat kidney (KNRK) cells under a high NO condition. Combined treatment of lipopolysaccharide (LPS, 1 microgram/ml) and tumor necrosis factor-alpha (TNF-alpha, 50 ...

journal_title：Free radical research

authors： Dobashi K,Asayama K,Nakane T,Kodera K,Hayashibe H,Nakazawa S

更新日期：2001-09-01 00:00:00

abstract：:We describe an altered membrane band 3 protein-mediated anion transport in erythrocytes exposed to peroxynitrite, and relate the loss of anion transport to cell damage and to band 3 oxidative modifications. We found that peroxynitrite down-regulate anion transport in a dose dependent relation (100-300 micromoles/l). H...

journal_title：Free radical research

authors： Celedón G,González G,Pino J,Lissi EA

更新日期：2007-03-01 00:00:00

abstract：:The seasonal variation of CuCl2-mediated low density lipoprotein (LDL) oxidation (10 microM Cu2+, lag phase, rate of oxidation and maximum absorbance at 234 nm) were measured in 43 men and women on 4-6 occasions (mean 5.7 +/- 0.5) over a 12-month period. The lag phase averaged 52.7 +/- 0.6 min and did not differ by ge...

journal_title：Free radical research

authors： Riemersma RA,Wilson R,Payne JA,Shepherd MJ

更新日期：2003-03-01 00:00:00

abstract：:Iron or oxygen regulates the stability of hypoxia inducible factor-1α (HIF-1α). We investigated whether ferrous glycinate would affect HIF-1α accumulation, aerobic glycolysis and mitochondrial energy metabolism in human A549 lung cancer cells. Incubation of A549 cells with ferrous glycinate decreased the protein level...

journal_title：Free radical research

authors： Kuo YT,Jheng JH,Lo MC,Chen WL,Wang SG,Lee HM

更新日期：2018-12-01 00:00:00

abstract：:Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from ...

journal_title：Free radical research

authors： Wei YP,Jia CN,Lan Y,Hou XQ,Zuo JJ,Cui H,Guan XJ,Wang Y,Mao GY

更新日期：2019-04-01 00:00:00

abstract：:Endothelial dysfunction is an early pathophysiological feature and independent predictor of poor prognosis in most forms of cardiovascular diseases. Epidemiological studies report an inverse association between dietary flavonoid consumption and mortality from cardiovascular diseases. In the present paper, we review th...

journal_title：Free radical research

authors： Perez-Vizcaino F,Duarte J,Andriantsitohaina R

更新日期：2006-10-01 00:00:00

abstract：:Adriamycin (ADR) is nephrotoxic. One component of ADR-induced nephropathy may be oxidative stress. This study used a recently developed line of transgenic mice (Nmt) on the FVB background strain, which over-express the antioxidant protein metallothionein (MT) in podocytes. Cultured podocytes from Nmt mice were resista...

journal_title：Free radical research

authors： Yang L,Zheng S,Epstein PN

更新日期：2009-02-01 00:00:00

abstract：:The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...

journal_title：Free radical research

authors： Song HC,Chen Y,Chen Y,Park J,Zheng M,Surh YJ,Kim UH,Park JW,Yu R,Chung HT,Joe Y

更新日期：2020-07-28 00:00:00

abstract：:Gastric inflammation is a highly complex biochemical protective response to cellular/tissue injury. When this process occurs in an uncontrolled manner, the result is excessive cellular/tissue damage that results chronic inflammation and destruction of normal tissue. Current evidence suggests that Helicobacter pylori (...

journal_title：Free radical research

authors： Yoshikawa T,Naito Y

更新日期：2000-12-01 00:00:00

abstract：:Peroxynitrite anion is a reactive and short-lived species and its formation in vivo has been implicated in several human diseases. In view of the potential usefulness of compounds that can protect against peroxynitrite or their reactive intermediates, a study focused on flavonoid compounds was carried out. Since the r...

journal_title：Free radical research

authors： Santos MR,Mira L

更新日期：2004-09-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...

journal_title：Free radical research

authors： Ben Anes A,Ben Nasr H,Garrouche A,Bchir S,Dhaouefi Z,Chabchoub E,Tabka Z,Chahed K

更新日期：2019-03-01 00:00:00

abstract：:p38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress. The most abundant family member is p38α, which helps to couple cell proliferation and growth in response to ce...

journal_title：Free radical research

authors： Tormos AM,Taléns-Visconti R,Nebreda AR,Sastre J

更新日期：2013-11-01 00:00:00

abstract：:Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...

journal_title：Free radical research

authors： Qin P,Li Y,Liu J,Wang N

更新日期：2020-10-01 00:00:00

abstract：:Degenerative diseases such as cancer are induced by oxidative genetic damage. Antioxidants can scavenge reactive oxygen species, but to prevent disease, they must do so quickly, before the DNA bases are damaged. In the present study, a novel method was established for evaluating the potency of antioxidants employing 2...

journal_title：Free radical research

authors： Sakakibara H,Ashida H,Kanazawa K

更新日期：2002-03-01 00:00:00

abstract：:Manganese superoxide dismutase (MnSOD) levels have been found to be low in human pancreatic cancer [Pancreas 26, (2003), 23] and human pancreatic cancer cell lines [Cancer Res. 63, (2003), 1297] when compared to normal human pancreas. We hypothesized that stable overexpression of pancreatic cancer cells with MnSOD cDN...

journal_title：Free radical research

authors： Ough M,Lewis A,Zhang Y,Hinkhouse MM,Ritchie JM,Oberley LW,Cullen JJ

更新日期：2004-11-01 00:00:00

abstract：:We have investigated the toxicity to human monocytemacrophages, and susceptibility to oxidation, of different individual dietary fatty acids in cholesterol esters and triglycerides, added to the cell cultures as coacervates with bovine serum albumin. Toxicity was assessed using release of radioactivity from cells prel...

journal_title：Free radical research

authors： Hardwick SJ,Carpenter KL,Law NS,Van Der Veen C,Marchant CE,Hird R,Mitchinson MJ

更新日期：1997-04-01 00:00:00

abstract：:The brain is highly susceptible to oxidative stress due to its high metabolic demand. Increased oxidative stress and depletion of glutathione (GSH) are observed with aging and many neurological diseases. Exercise training has the potential to reduce oxidative stress in the brain. In this study, nine healthy sedentary ...

journal_title：Free radical research

authors： Rai S,Chowdhury A,Reniers RLEP,Wood SJ,Lucas SJE,Aldred S

更新日期：2018-01-01 00:00:00

abstract：:We investigated hepatoprotective activity and antioxidant effect of the 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene that purified from Morus bombycis Koidzumi roots against CCl4-induced liver damage in rats. The 2,5-dihydroxy-4,3'-di(beta-D-glucopyranosyloxy)-trans-stilbene displayed dose-dependent ...

journal_title：Free radical research

authors： Jin YS,Lee MJ,Han W,Heo SI,Sohn SI,Wang MH

更新日期：2006-09-01 00:00:00

abstract：:5-(2,2-dimethyl-1,3-propoxy cyclophosphoryl)-5-methyl-1-pyrroline N-oxide (CYPMPO), a new cyclic DEPMPO-type nitrone was evaluated for spin-trapping capabilities toward hydroxyl and superoxide radicals. CYPMPO is colorless crystalline and freely soluble in water. Both the solid and diluted aqueous solution did not dev...

journal_title：Free radical research

authors： Kamibayashi M,Oowada S,Kameda H,Okada T,Inanami O,Ohta S,Ozawa T,Makino K,Kotake Y

更新日期：2006-11-01 00:00:00

abstract：:6-Hydroxydopamine (6-OHDA) is a neurotoxin to produce an animal model of Parkinson's disease. 6-OHDA increased the formation of 8-oxo-7, 8-dihydro-2'-deoxyguanosine (8-oxodG), a biomarker of oxidatively damaged DNA, and induced apoptosis in human neuroblastoma SH-SY5Y cells. Iron or copper chelators inhibited 6-OHDA-i...

journal_title：Free radical research

authors： Kobayashi H,Oikawa S,Umemura S,Hirosawa I,Kawanishi S

更新日期：2008-07-01 00:00:00

abstract：:Macrophages produce reactive oxygen species such as O2-, H2O2 and *OH that contribute to the pathogenesis of diseases such as inflammation and atherosclerosis. The cells have multiple defense systems against those reactive oxygen species, and we describe here such an oxidative stress-inducible defense system. Upon exp...

journal_title：Free radical research

authors： Ishii T,Itoh K,Sato H,Bannai S

更新日期：1999-10-01 00:00:00

abstract：:Isolated Langendorff-perfused rat hearts, after 30 min of preperfusion, were submitted to increasing times of global normothermic ischemia (1, 2, 5, 10, 20 and 30 min) or to the same times of ischemia followed by 30 min of reperfusion. Analysis of malondialdehyde, ascorbic acid, oxypurines, nucleosides, nicotinic coen...

journal_title：Free radical research

authors： Tavazzi B,Di Pierro D,Bartolini M,Marino M,Distefano S,Galvano M,Villani C,Giardina B,Lazzarino G

更新日期：1998-01-01 00:00:00

abstract：:Adriamycin (ADR) is a chemotherapeutic agent useful in treating various cancers. ADR is a quinone-containing anthracycline chemotherapeutic and is known to produce reactive oxygen species (ROS) in heart. Application of this drug can have serious side effects in various tissues, including brain, apart from the known ca...

journal_title：Free radical research

authors： Joshi G,Sultana R,Tangpong J,Cole MP,St Clair DK,Vore M,Estus S,Butterfield DA

更新日期：2005-11-01 00:00:00

abstract：:The effects of intravenous administration of alpha-phenyl N-tert-butyl nitrone (PBN) on cortical cerebral blood flow (CBF) were examined in Wistar rats under pentobarbital anesthesia and artificial ventilation. The cortical CBF in parietal cortex was measured by laser Doppler flowmetry. Intravenous administrations of ...

journal_title：Free radical research

authors： Inanami O,Kuwabara M

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...

journal_title：Free radical research

authors： Iguchi T,Nishikawa M,Chang B,Muroya O,Sato EF,Nakatani T,Inoue M

更新日期：2004-04-01 00:00:00

abstract：:Coenzyme Q10 (CoQ10) is an essential cofactor of the electron transport gene as well as an important antioxidant, which is particularly effective within mitochondria. A number of prior studies have shown that it can exert efficacy in treating patients with known mitochondrial disorders. We investigated the potential u...

journal_title：Free radical research

authors： Beal MF

更新日期：2002-04-01 00:00:00