Abstract:
:Oxidative DNA damage pathogenically links to some major diseases. This study aimed to comprehensively assess the association between serum total cholesterol (TC) and oxidative DNA damage based on propensity score matching (PSM) method. A total of 407 participants chronically exposed to arsenic via drinking water from China were enrolled. Oxidative DNA damage was determined with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). Serum TC was classified into favourable TC (FTC, TC <5.18 mmol/L) and unfavourable TC (NFTC, TC ≥5.18 mmol/L) categories. Multivariable generalised linear regression model was applied to examine the association. Of 407 participants, 125 pairs with FTC and NFTC subjects were matched using PSM. Urinary 8-OHdG/creatinine levels in NFTC were significantly higher than those in FTC category (p = .002). As compared to the counterparts, additional adjusted log-transformed 8-OHdG/creatinine increase was observed in NFTC for unmatched (β = 0.12, p = .052) and matched (β = 0.17, p < .001) participants, respectively. We also detected obviously increased log-transformed urinary 8-OHdG/creatinine with per interquartile range raise of serum TC either in unmatched (β = 0.10, p = .007) or matched (β = 0.16, p = .003) subjects. In conclusion, serum TC was independently associated with oxidative DNA damage. Our findings provided new insights on the health promotion of lipids relevant to the early warning of diseases due to oxidative DNA damage.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Wei YP,Jia CN,Lan Y,Hou XQ,Zuo JJ,Cui H,Guan XJ,Wang Y,Mao GYdoi
10.1080/10715762.2019.1595613subject
Has Abstractpub_date
2019-04-01 00:00:00pages
411-417issue
4eissn
1071-5762issn
1029-2470journal_volume
53pub_type
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journal_title:Free radical research
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