Haem oxygenase-1 inhibits neointimal hyperplasia in rat by histone deacetylase 2.

abstract：:We have reported previously that the apparent rate of peroxynitrite (ONOO(-) ) decay, as followed from its absorbance at 302 nm, decreases in the presence of hydrogen peroxide, mannitol and ethanol (Alvarez et al., 1995, Chem. Res. Toxicol. 8:859-864; Alvarez et al., 1998, Free Radic. Biol. Med. 24:1331-1337). Recentl...

journal_title：Free radical research

authors： Alvarez B,Radi R

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:The objective of the present study was to determine whether single administration of the antioxidant enzyme bovine superoxide dismutase (bSOD) after radiation therapy (RT) mitigates development of pulmonary toxicity in rats. METHODS:Female F344 rats (n = 60) were divided among six experimental groups: (1) R...

journal_title：Free radical research

authors： Antonic V,Rabbani ZN,Jackson IL,Vujaskovic Z

更新日期：2015-10-01 00:00:00

abstract：:Aging is a multifold process affected by many genes and thus many biochemical pathways. This conclusion is underscored by the failure to find simple central controls for the aging process during the 20th Century. This situation poses a fundamental challenge to anti-aging medicine: how to develop effective therapies fo...

journal_title：Free radical research

authors： Rose MR,Mueller LD,Long AD

更新日期：2002-12-01 00:00:00

abstract：:A glycomic approach to the identification of target molecules in glycosyltransferase gene targeting mice is a promising strategy to understand the biological significance of glycosyltransferase genes in vivo. In order to understand the biological effects of N-acetylglucosaminyltransferase III (GnT-III) on tumor format...

journal_title：Free radical research

authors： Ekuni A,Miyoshi E,Ko JH,Noda K,Kitada T,Ihara S,Endo T,Hino A,Honke K,Taniguchi N

更新日期：2002-08-01 00:00:00

abstract：:The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 ...

journal_title：Free radical research

authors： Borrás C,Gómez-Cabrera MC,Viña J

更新日期：2011-06-01 00:00:00

abstract：:There is a convincing body of evidence that oxidative stress is involved in the pathogenesis of acute pancreatitis. The effects of different radical scavengers suggested that reactive oxygen metabolites are generated at very early stage of disease and contribute to amplify the pancreatic damage. Oxidative stress is al...

journal_title：Free radical research

authors： Closa D

更新日期：2013-11-01 00:00:00

abstract：:Dihydrocalcein (H2-calcein) is recommended as a superior probe for intracellular radical (ROS) detection as different to dichlorodihydrofluorescein (H2-DCF), its oxidation product calcein is thought not to leak out of cells. We determined whether H2-calcein is a useful tool to measure ROS in vascular smooth muscle cel...

journal_title：Free radical research

authors： Keller A,Mohamed A,Dröse S,Brandt U,Fleming I,Brandes RP

更新日期：2004-12-01 00:00:00

abstract：:The hydroxyl radical (.OH)-scavenging activity of d-2-[4-(3-methyl-2-thienyl)phenyl]propionic acid (M-5011), a novel nonsteroidal anti-inflammatory drug (NSAID), and that of several other NSAIDs were investigated by the hyaluronic acid (HA) degradation method and the electron spin resonance (ESR) spin-trapping techniq...

journal_title：Free radical research

authors： Kataoka M,Tonooka K,Ando T,Imai K,Aimoto T

更新日期：1997-10-01 00:00:00

abstract：:Oxidative stress appears to be implicated in the pathogenesis of various diseases including hepatotoxicity. Although intracellular Ca2+ signals have been suggested to play a role in the oxidative damage of hepatocytes, the sources and effects of oxidant-induced intracellular Ca2+ increases are currently debatable. Thu...

journal_title：Free radical research

authors： Kim JA,Kang YS,Lee SH,Lee YS

更新日期：2000-09-01 00:00:00

abstract：:Tetrahydrobiopterin (BH4) is a ubiquitous pteridine metabolite that serves as a NOS cofactor. Recently, we showed that BH4 efficiently inhibits superoxide generation from the heme group at the oxygenase domain of eNOS. This role indicates that BH4 acts as a redox switch in the catalytic mechanism of the enzyme, which ...

journal_title：Free radical research

authors： Vásquez-Vivar J,Kalyanaraman B,Martásek P

更新日期：2003-02-01 00:00:00

abstract：:The in vitro toxicity of the reactive oxygen species generating enzyme xanthine oxidoreductase (XOR) to human peripheral blood lymphocytes was studied after stimulation with phytohaemoagglutinin or anti-CD3/CD28 antibodies. Apoptosis and necrosis were induced by the XOR/hypoxanthine system in a time- and concentration...

journal_title：Free radical research

authors： Battelli MG,Musiani S,Tazzari PL,Stirpe F

更新日期：2001-12-01 00:00:00

abstract：:Araucaria angustifolia (Bert.) O. Kuntze is a species critically endangered of extinction and its development and propagation is strongly affected by abiotic stress. We have previously shown the activation of uncoupling protein in A. angustifolia embryogenic stem cells subjected to cold stress. Now, we have furthered ...

journal_title：Free radical research

authors： Dorigan de Matos Furlanetto AL,Valente C,Martinez GR,Merlin Rocha ME,Maurer JBB,Cadena SMSC

更新日期：2019-01-01 00:00:00

abstract：:MCI-186 (3-methyl-1-phenyl-2-pyrazolin-5-one) is a newly developed antioxidant which has been shown to reduce brain edema in cerebral ischemia through inhibition of the lipoxygenase pathway of arachidonic acid. However, its effect on myocardial reperfusion injury after prolonged ischemia has not yet been demonstrated....

journal_title：Free radical research

authors： Minhaz U,Tanaka M,Tsukamoto H,Watanabe K,Koide S,Shohtsu A,Nakazawa H

更新日期：1996-05-01 00:00:00

abstract：:The objective of this study was to elucidate the impact of physical activity during the growth period as well as on oxidative stress and antioxidative potential in adulthood. The experimental animals used were four-week old male Wistar rats, which were randomly divided into three groups. The exercise loads were as fol...

journal_title：Free radical research

authors： Lee S,Hashimoto J,Suzuki T,Satoh A

更新日期：2017-02-01 00:00:00

abstract：:To study the role of oxidative stress in hypertension and pre-hypertension, this study analysed plasma levels of reactive carbonyl species (RCS) in 1204 Chinese Han adults. Results showed a statistically significant positive correlation (p < 0.001) between blood pressure and plasma RCS levels with or without being adj...

journal_title：Free radical research

authors： Chen K,Xie F,Liu S,Li G,Chen Y,Shi W,Hu H,Liu L,Yin D

更新日期：2011-05-01 00:00:00

abstract：:The imbalance between the reactive oxygen (ROS) and nitrogen (RNS) species production and their handling by the antioxidant machinery (low molecular weight antioxidant molecules and antioxidant enzymes), also known as oxidative stress, is a condition caused by physiological and pathological processes. Moreover, oxidat...

journal_title：Free radical research

authors： Gorini G,Gamberi T,Fiaschi T,Mannelli M,Modesti A,Magherini F

更新日期：2019-02-01 00:00:00

abstract：:Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...

journal_title：Free radical research

authors： Ghosh N,Ghosh R,Mandal SC

更新日期：2011-08-01 00:00:00

abstract：:The purpose of this double clinical study was (1) to evaluate the effect of one single intake (300 ml) of red wine (RW) on the plasma antioxidant capacity (pAOC) and plasma phenolics over the 24-h time period following the intake, and (2) to compare the long-term effects of daily intakes (250 ml/d) of RW, white wine (...

journal_title：Free radical research

authors： Cartron E,Fouret G,Carbonneau MA,Lauret C,Michel F,Monnier L,Descomps B,Léger CL

更新日期：2003-09-01 00:00:00

abstract：:Nerve growth factor (NGF) is one of the several structurally related proteins, named neurotrophins (NTs), that regulate neuronal survival, development, function, and plasticity. Moreover, NGF is an important activator of antioxidant mechanisms. These NGF functions are mediated by tropomyosin-related kinase receptor A ...

journal_title：Free radical research

authors： Valdovinos-Flores C,Gonsebatt ME

更新日期：2013-05-01 00:00:00

abstract：:Autophagy modulation is a potential therapeutic strategy for breast cancer, and a previous study indicated that metformin exhibits significant anti-carcinogenic activity. However, the ability of metformin to induce autophagy and its role in breast cancer cell death remains unclear. In this study, we exposed MCF-7 cell...

journal_title：Free radical research

authors： Tan M,Wu A,Liao N,Liu M,Guo Q,Yi J,Wang T,Huang Y,Qiu B,Zhou W

更新日期：2018-08-01 00:00:00

abstract：:Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-p...

journal_title：Free radical research

authors： Wang H,Jenner AM,Lee CY,Shui G,Tang SY,Whiteman M,Wenk MR,Halliwell B

更新日期：2007-04-01 00:00:00

abstract：:The intracellular superoxide and glutathione disulphide concentrations increased in Penicillium chrysogeum treated with 50, 250 or 500 microM menadione (MQ). A significant increase in the intracellular peroxide concentration was also observed when mycelia were exposed to 250 or 500 microM MQ. The specific activity of ...

journal_title：Free radical research

authors： Emri T,Pócsi I,Szentirmai A

更新日期：1999-02-01 00:00:00

abstract：:Adenosine levels are increased in stress and act as anti-oxidant and anti-inflammatory mediators by binding to 4 G-protein-coupled receptors. Using genetically modified mice lacking A(1) and A(3) adenosine receptors, treated with ip buthionine-[S,R]-sulphoximine injections to inhibit gamma-glutamylcysteine ligase, the...

journal_title：Free radical research

authors： Conte C,Grottelli S,Prudenzi E,Bellezza I,Fredholm BB,Minelli A

更新日期：2009-03-01 00:00:00

abstract：:Chronic obstructive pulmonary disease (COPD) is a major cause of mortality that has been associated with inflammation and oxidative stress. The purpose of the present case-control study was to determine the relationships between oxidative stress-related genetic variants and the risk and severity of COPD, as well as, t...

journal_title：Free radical research

authors： Ben Anes A,Ben Nasr H,Garrouche A,Bchir S,Dhaouefi Z,Chabchoub E,Tabka Z,Chahed K

更新日期：2019-03-01 00:00:00

abstract：:Hydroxyl and 1-hydroxyethyl radical adducts of 5,5-dimethylpyrroline N-oxide (DMPO) were prepared by photolysis, and mechanisms for loss of their EPR signals in rat liver microsomal suspensions were evaluated. Rates of NADPH-dependent EPR signal loss were more rapid in phosphate buffer than in Tris buffer. Addition of...

journal_title：Free radical research

authors： Reinke LA,Moore DR,McCay PB

更新日期：1996-12-01 00:00:00

abstract：:The effect of antioxidant supplementation on biomarkers of oxidative stress was investigated in a 6-week intervention study in 60 overweight men. The supplement contained a combination of antioxidants aiming to correspond to the antioxidant content found in a diet rich in fruit and vegetables. Placebo, single or doubl...

journal_title：Free radical research

authors： Rytter E,Johansson C,Vessby B,Sjödin A,Möller L,Akesson B,Basu S

更新日期：2010-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...

journal_title：Free radical research

authors： Hou C,Peng Y,Qin C,Fan F,Liu J,Long J

更新日期：2018-12-01 00:00:00

abstract：:We tested the hypothesis that hypertension associated with polycythemia vera (PV) may be related to hemoglobin released from erythrocytes (cell-free hemoglobin, fHb). We assessed hematocrit, mean arterial pressure (MAP), blood viscosity, and the level of fHb and nitrite/nitrate (NOx) in the plasma of 73 PV patients an...

journal_title：Free radical research

authors： Rusak T,Misztal T,Piszcz J,Tomasiak M

更新日期：2014-02-01 00:00:00

abstract：:Interactions between transition metal ions and polyphenols can result in complexation, redox or polymerization, but the relative importance of these reactions is unclear. The present paper reports results from the reaction of gallic acid (GA) with Cu(II) using electron paramagnetic resonance (EPR) and UV/visible spect...

journal_title：Free radical research

authors： Severino JF,Goodman BA,Reichenauer TG,Pirker KF

更新日期：2011-02-01 00:00:00

abstract：:Ribonucleotide reductases catalyze the irreversible reductive formation of 2'-deoxyribonucleotides required for DNA replication and cell proliferation, and a radical mechanism was assumed to be involved in this reaction. In order to search for a radical in the aerobic manganese ribonucleotide reductase (Mn-RRase) by e...

journal_title：Free radical research

authors： Griepenburg U,Lassmann G,Auling G

更新日期：1996-06-01 00:00:00