EPR studies on the effects of complexation of heme by hemopexin upon its reactions with organic peroxides.

Abstract:

:Hemopexin, a heme-binding serum glycoprotein, is thought to play an important role in the prevention of oxidative damage that may be catalysed by free heme. Through the use of EPR techniques, the generation of free radicals from organic hydroperoxides by heme and heme-hemopexin complexes, and the concomitant formation of high oxidation-state iron species has been studied; these species are implicated as causative agents in processes such as cardiovascular disease and carcinogenesis. From the rates of production of these species from both n-alkyl and branched hydroperoxides, it has been inferred that the dramatic reduction in the yield of oxidising species generated by heme upon its complexation with hemopexin arises from steric hindrance of the access of hydroperoxide to the bound heme.

journal_name

Free Radic Res

journal_title

Free radical research

authors

Timmins GS,Davies MJ,Song DX,Muller-Eberhard U

doi

10.3109/10715769509065277

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

559-69

issue

6

eissn

1071-5762

issn

1029-2470

journal_volume

23

pub_type

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