Abstract:
:Glutathione plays a central role in the maintenance of cellular antioxidant defense. The alterations in the glutathione and associated recyclic enzymes caused by both exercise training and ethanol are well documented; however, their interactive effects with age are not well understood. Therefore, the influence of ageing and the interactive effects of exercise training and ethanol on the myocardial glutathione system in 3 months and 18 months old rats were examined. The results showed a significant (p<0.01) reduction in GSH content, Se and non-Se GSH-Px, GR and GST activities in the myocardium of rat with age. A significant increase (p<0.05) in the activities of these enzymes was observed in both age groups of rats in response to exercise training. This exercise-induced elevation of Se and non-Se GSH-Px and GR activities was more pronounced in the 18 months old rats when compared to 3 months old rats. Ethanol consumption significantly (p<0.05) reduced the GSH content, Se and non-Se GSH-Px and GR activities in both age groups of rats. In contrast, ethanol consumption significantly (p<0.05) increased the activity of GST. The combined action of exercise plus ethanol significantly (p<0.05) elevated the GSH content, Se and non-Se GSH-Px, GR and GST activities when compared to the ethanol treated rats in both age groups, indicating the suppression of ethanol-induced oxidative stress by exercise training. In conclusion, there was a compensatory myocardial response lessening ethanol-induced oxidative stress by exercise training, which seemed to result from the higher activity of glutathione recycling and utilizing enzymes, which may be critical for preventing chronic oxidative damage to the myocardium during ageing and even due to ethanol consumption.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Kakarla P,Kesireddy S,Christiaan Ldoi
10.1080/10715760802069462subject
Has Abstractpub_date
2008-05-01 00:00:00pages
428-34issue
5eissn
1071-5762issn
1029-2470journal_volume
42pub_type
杂志文章abstract::Oxidative stress is suggested as a potential mechanism in impaired foetal growth, smaller birth size and thus subsequently adult chronic diseases. We have investigated associations between oxidative stress in pregnancy and birth anthropometry (weight, height, head and chest circumferences). In the MINIMat-trial (Mater...
journal_title:Free radical research
pub_type: 临床试验,杂志文章
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abstract::Manganese superoxide dismutase (MnSOD) is essential for life as dramatically illustrated by the neonatal lethality of mice that are deficient in MnSOD. In addition, mice expressing only 50% of the normal compliment of MnSOD demonstrate increased susceptibility to oxidative stress and severe mitochondrial dysfunction r...
journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300131
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journal_title:Free radical research
pub_type: 杂志文章
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journal_title:Free radical research
pub_type: 杂志文章,评审
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.557723
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pub_type: 杂志文章
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769509065255
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pub_type: 杂志文章
doi:10.3109/10715762.2011.602345
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pub_type: 杂志文章
doi:10.1080/10715760600883254
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journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2013.815346
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journal_title:Free radical research
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doi:10.3109/10715769809065799
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journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715769809065814
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journal_title:Free radical research
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pub_type: 杂志文章,评审
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abstract::Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...
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