Abstract:
:Cholesterol is an essential component of mammalian plasma membrane. Alterations in sterol metabolism or oxidation have been linked to various pathological conditions, including cardiovascular diseases, cancer, and neurodegenerative disorders. Unsaturated sterols are vulnerable to oxidation induced by singlet oxygen and other reactive oxygen species. This process yields reactive sterol oxidation products, including hydroperoxides, epoxides as well as aldehydes. These oxysterols, in particular those with high electrophilicity, can modify nucleophilic sites in biomolecules and affect many cellular functions. Here, we review the generation and measurement of reactive sterol oxidation products with emphasis on cholesterol hydroperoxides and aldehyde derivatives (electrophilic oxysterols) and their effects on protein modifications.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Miyamoto S,Lima RS,Inague A,Viviani LGdoi
10.1080/10715762.2021.1879387subject
Has Abstractpub_date
2021-01-26 00:00:00pages
1-56eissn
1071-5762issn
1029-2470pub_type
杂志文章abstract::In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...
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pub_type: 杂志文章,评审
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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