Comparison of the phenolic composition of fruit juices by single step gradient HPLC analysis of multiple components versus multiple chromatographic runs optimised for individual families.

abstract：:We have here investigated possible occurrence of bicarbonate-dependent, carbonate radical anion (CO(3)(•-))-driven tocopherol-mediated human LDL peroxidation (TMP) in vitro and in vivo. CO(3)(•-), generated in vitro by the SOD1/H(2)O(2)/bicarbonate system, readily promoted TMP, which was dependent on α-tocopherol and ...

journal_title：Free radical research

authors： Lapenna D,Ciofani G,Cuccurullo C,Neri M,Giamberardino MA,Cuccurullo F

更新日期：2012-11-01 00:00:00

abstract：:Alzheimer's disease (AD) is characterised as a provoked inflammatory response and oxidative stress along with amyloid β peptide (Aβ) deposition and neurofibrillary tangles in the brain, and effective treatment is greatly needed. Molecular hydrogen, which has been proposed to be an antioxidant that selectively reduces ...

journal_title：Free radical research

authors： Hou C,Peng Y,Qin C,Fan F,Liu J,Long J

更新日期：2018-12-01 00:00:00

abstract：:Hypericin and pseudohypericin are polycyclic-phenolic structurally related compounds found in Hypericum perforatum L. (St John's wort). As hypericin has been found to bind to LDL one may assume that it can act as antioxidant of LDL lipid oxidation, a property which is of prophylactic/therapeutic interest regarding ath...

journal_title：Free radical research

authors： Laggner H,Schreier S,Hermann M,Exner M,Mühl A,Gmeiner BM,Kapiotis S

更新日期：2007-02-01 00:00:00

abstract：:Glucose at pathophysiological concentrations was able to accelerate copper-induced oxidation of isolated low-density lipoprotein (LDL) and whole serum. The efficiency of glucose was favored under the following circumstances: (a) when LDL oxidation was induced by low copper concentration, (b) when LDL was partly oxidiz...

journal_title：Free radical research

authors： Leoni V,Albertini R,Passi A,Abuja PM,Borroni P,D'Eril GM,De Luca G

更新日期：2002-05-01 00:00:00

abstract：:γ-Tocopherol (γ-T) scavenges reactive nitrogen species (RNS) to form 5-NO2-γ-T (NGT). However, α-T supplementation decreases circulating γ-T, which could limit its RNS scavenging activities. We hypothesized that α-T supplementation would mitigate NGT accumulation by impairing γ-T status. Healthy smokers (21 ± 1 y, n =...

journal_title：Free radical research

authors： Pei R,Mah E,Leonard SW,Traber MG,Bruno RS

更新日期：2015-01-01 00:00:00

abstract：:Heme oxygenase is the rate limiting enzyme in heme degradation to carbon monoxide (CO), iron and bilirubin. The inducible isoform of the protein, heme oxygenase-1 (HO-1), is susceptible to up-regulation by a diverse variety of conditions and agents in mammalian tissue, leading to the common conception that HO-1 is a s...

journal_title：Free radical research

authors： Foresti R,Motterlini R

更新日期：1999-12-01 00:00:00

abstract：:During the early postimplantation period, rodent embryos survive in a relatively anaerobic environment in utero and are vulnerable to a high oxygen pressure. They become resistant to oxygen stress when they are exposed to a higher oxygen pressure after the uteroplacental circulation is established. However, it is unkn...

journal_title：Free radical research

authors： Kobayashi-Miura M,Nakamura H,Yodoi J,Shiota K

更新日期：2002-09-01 00:00:00

abstract：:Intestinal injury is inevitable during exposure to high radiation doses and is a common side effect observed during abdominal/pelvic radiotherapy. Yet, no radiation countermeasures are available for gastrointestine (GI) injury management. The aim of this study is to determine the effects of podophyllotoxin and rutin i...

journal_title：Free radical research

authors： Dutta A,Gupta ML,Verma S

更新日期：2018-01-01 00:00:00

abstract：:Flavonoids are components of fruit and vegetables that may be beneficial in the prevention of disease such as cancer and cardiovascular diseases. Their beneficial effects will be dependent upon their uptake and disposition in tissues and cells. The metabolism and pharmacokinetics of flavonoids has been an area of acti...

journal_title：Free radical research

authors： Manach C,Donovan JL

更新日期：2004-08-01 00:00:00

abstract：:The increasing knowledge on the participation of free radicals in many diverse clinical and pathological conditions, has consequently expanded the search for new and versatile antioxidants aimed at combating oxidative stress. Our interest in this field concerns aromatic indolinonic aminoxyls (nitroxides) which efficie...

journal_title：Free radical research

authors： Damiani E,Carloni P,Stipa P,Greci L

更新日期：1999-08-01 00:00:00

abstract：:A glycomic approach to the identification of target molecules in glycosyltransferase gene targeting mice is a promising strategy to understand the biological significance of glycosyltransferase genes in vivo. In order to understand the biological effects of N-acetylglucosaminyltransferase III (GnT-III) on tumor format...

journal_title：Free radical research

authors： Ekuni A,Miyoshi E,Ko JH,Noda K,Kitada T,Ihara S,Endo T,Hino A,Honke K,Taniguchi N

更新日期：2002-08-01 00:00:00

abstract：:In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...

journal_title：Free radical research

authors： Chainy GBN,Sahoo DK

更新日期：2020-01-01 00:00:00

abstract：:Radicals from one-electron oxidation of 4-hydroxycinnamate, ferulate and 3,4-dihydroxycinnamate have been formed by reaction with the oxidising triplet state of duroquinone. All three compounds react with triplet duroquinone with second order rate constants close to the diffusion-controlled limit. The identity of the ...

journal_title：Free radical research

authors： Bisby RH,Parker AW

更新日期：2001-07-01 00:00:00

abstract：:Effects of vitamins B, C, E, K and P, as well as coenzymes Q, on formation of final products of radiation-induced free-radical transformations of ethanol, ethylene glycol, alpha-methylglycoside and glucose in aqueous solutions were studied. Based on the obtained results, it can be concluded that there are substances a...

journal_title：Free radical research

authors： Shadyro OI,Sosnovskaya AA,Edimecheva IP,Grintsevich IB,Lagutin PY,Alekseev AV,Kazem K

更新日期：2005-07-01 00:00:00

abstract：:Indoles are very common in the body and diet and participate in many biochemical processes. A total of twenty-nine indoles and analogs were examined for their properties as antioxidants and radical scavengers against 2,2'-Azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) ABTS*+ radical cation. With only a few exception...

journal_title：Free radical research

authors： Herraiz T,Galisteo J

更新日期：2004-03-01 00:00:00

abstract：:Of all the aerobic respiration by-products, cytotoxic superoxide derived from mitochondrial-leaked electrons, is the only one known to be disposed of intracellularly. Is this fate the only destiny for mitochondrial-leaked electrons? When Cynomolgus monkeys were injected intravenously with reactive oxygen species (ROS)...

journal_title：Free radical research

authors： Guo J,Xu H,Liu S,Wang Z,Dai Y,Lu J,Zheng S,Xu D,Zhou J,Ke L,Cheng X,Xu M,Zhang X,Guo Y,Lin Y,Ding W,Gao G,Wang H,Chen Q,Yu X,Chen H,Qin L,Sun X,Li Z,Zheng S,Wang J,Cheng Y,Qiu S,Hu Y,Huang P,Li

更新日期：2019-12-01 00:00:00

abstract：:APE1/Ref-1, the mammalian ortholog of E. coli Xth, and a multifunctional protein possessing both DNA repair and transcriptional regulatory activities, has dual role in controlling cellular response to oxidative stress. It is rate-limiting in repair of oxidative DNA damage including strand breaks and also has co-transc...

journal_title：Free radical research

authors： Fantini D,Vascotto C,Deganuto M,Bivi N,Gustincich S,Marcon G,Quadrifoglio F,Damante G,Bhakat KK,Mitra S,Tell G

更新日期：2008-01-01 00:00:00

abstract：:Free radical oxidation of cholesterol and its precursors contribute significantly to the pathophysiology of a number of human diseases. This review intends to summarize recent developments and provide a perspective on the reactivities of sterols toward free radical oxidation, the free radical reaction mechanism, and t...

journal_title：Free radical research

authors： Xu L,Porter NA

更新日期：2015-01-01 00:00:00

abstract：:Lipid peroxidation (LPO) product accumulation in human tissues is a major cause of tissular and cellular dysfunction that plays a major role in ageing and most age-related and oxidative stress-related diseases. The current evidence for the implication of LPO in pathological processes is discussed in this review. New d...

journal_title：Free radical research

authors： Negre-Salvayre A,Auge N,Ayala V,Basaga H,Boada J,Brenke R,Chapple S,Cohen G,Feher J,Grune T,Lengyel G,Mann GE,Pamplona R,Poli G,Portero-Otin M,Riahi Y,Salvayre R,Sasson S,Serrano J,Shamni O,Siems W,Siow RC,Wis

更新日期：2010-10-01 00:00:00

abstract：:Oxidatively generated damage to nucleic acids may play an important role in the pathophysiological processes of a variety of diseases. 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGsn) and 8-oxo-7,8-dihydroguanosine (8-oxo-Gsn) are oxidatively generated products of DNA and RNA, respectively. Our previous studies have s...

journal_title：Free radical research

authors： Mao YH,Weng QH,Xu LN,Li XY,Zhao B,Sun Y,Nie JJ,Hu JH,Zhou Q,Zhang LQ,Guo J,Zuo MZ,Ito S,Cai JP

更新日期：2017-06-01 00:00:00

abstract：:Hemopexin, a heme-binding serum glycoprotein, is thought to play an important role in the prevention of oxidative damage that may be catalysed by free heme. Through the use of EPR techniques, the generation of free radicals from organic hydroperoxides by heme and heme-hemopexin complexes, and the concomitant formation...

journal_title：Free radical research

authors： Timmins GS,Davies MJ,Song DX,Muller-Eberhard U

更新日期：1995-12-01 00:00:00

abstract：:The response of HeLa cells to subcellular spatially localized two-photon irradiation of a singlet oxygen photosensitizer (protoporphyrin IX, PpIX) using a focused laser was assessed. Upon irradiation under these conditions, a localized population of PpIX excited states can be produced with meaningful intracellular spa...

journal_title：Free radical research

authors： Gollmer A,Besostri F,Breitenbach T,Ogilby PR

更新日期：2013-09-01 00:00:00

abstract：:Hypoxia is a well-known threat to neuronal cells and triggers the pathophysiological syndromes in extreme environments such as high altitudes and traumatic conditions such as stroke. Among several prophylactic molecules proven suitable for ameliorating free radical damage, NAP (an octapeptide with initial amino acids:...

journal_title：Free radical research

authors： Arya A,Meena R,Sethy NK,Das M,Sharma M,Bhargava K

更新日期：2015-04-01 00:00:00

abstract：:The intestinal tract, known for its capability for self-renew, represents the first barrier of defence between the organism and its luminal environment. The thiol/disulfide redox systems comprising the glutathione/glutathione disulfide (GSH/GSSG), cysteine/cystine (Cys/CySS) and reduced and oxidized thioredoxin (Trx/T...

journal_title：Free radical research

authors： Circu ML,Aw TY

更新日期：2011-11-01 00:00:00

abstract：:We evaluated whether nutritional vitamin A deficiency generates oxidative stress and inflammation in aorta. Wistar male rats (21 days old) were given free access to a control (8 mg retinol as retinyl palmitate/kg) or a vitamin A- deficient diet for three months. One group of deficient animals was fed with the control ...

journal_title：Free radical research

authors： Gatica L,Alvarez S,Gomez N,Zago MP,Oteiza P,Oliveros L,Gimenez MS

更新日期：2005-06-01 00:00:00

abstract：:There is clear evidence implicating oxidative stress in the pathology of many neurodegenerative diseases. Reactive oxygen species (ROS) are the primary mediators of oxidative stress, and hydrogen peroxide, a key ROS, is generated during aggregation of the amyloid proteins associated with some of these diseases. Hydrog...

journal_title：Free radical research

authors： Tabner BJ,Turnbull S,King JE,Benson FE,El-Agnaf OM,Allsop D

更新日期：2006-07-01 00:00:00

abstract：:Oxidatively induced damage caused by free radicals and other DNA-damaging agents generate a plethora of products in the DNA of living organisms. There is mounting evidence for the involvement of this type of damage in the etiology of numerous diseases including carcinogenesis. For a thorough understanding of the mecha...

journal_title：Free radical research

authors： Dizdaroglu M,Coskun E,Jaruga P

更新日期：2015-05-01 00:00:00

abstract：:Increased reactive oxygen species (ROS) and lipid peroxidation may be implicated in the pathogenesis of preeclampsia by causing cell (membrane) damage and impaired endothelial function. Carbonyl derivatives of proteins, or protein carbonyls, may be sensitive biomarkers of ROS-mediated damage. The aim of the study was ...

journal_title：Free radical research

authors： Zusterzeel PL,Mulder TP,Peters WH,Wiseman SA,Steegers EA

更新日期：2000-11-01 00:00:00

abstract：:The potential protective effect of the dietary antioxidant curcumin (120 mg/Kg/day for 6 days) against the renal injury induced by maleate was evaluated. Tubular proteinuria and oxidative stress were induced by a single injection of maleate (400 mg/kg) in rats. Maleate-induced renal injury included increase in renal v...

journal_title：Free radical research

authors： Tapia E,Sánchez-Lozada LG,García-Niño WR,García E,Cerecedo A,García-Arroyo FE,Osorio H,Arellano A,Cristóbal-García M,Loredo ML,Molina-Jijón E,Hernández-Damián J,Negrette-Guzmán M,Zazueta C,Huerta-Yepez S,Reyes JL,Madero M

更新日期：2014-11-01 00:00:00

abstract：:Individuals with low serum cholesterol experience greater than expected age-adjusted mortality from non-atherosclerotic diseases, including cancer, respiratory and digestive illnesses, but the basis for these associations remains unclear. The current investigation considered the hypothesis that hypocholesterolemia is ...

journal_title：Free radical research

authors： Muldoon MF,Kritchevsky SB,Evans RW,Kagan VE

更新日期：1996-09-01 00:00:00