Abstract:
:A study of peroxyl radical-mediated bovine serum albumin oxidation in the presence of the quinolinic aminoxyl 1,2-dihydro-2,2-diphenyl-4-ethoxy-quinoline-1-oxyl (QAO) was carried out in order to test its efficiency as a protein antioxidant. Albumin oxidation was induced by the tert-butylhydroperoxide/PbO2 system. The extent of protein oxidation, measured by monitoring the formation of carbonyl groups, was considerably reduced in the presence of QAO. ESR measurements were carried out to confirm the consumption of the nitroxide during oxidation and its incorporation in the protein. The data obtained indicate that the quinolinic aminoxyl function can be used as an effective antioxidant in biological systems.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Tanfani F,Carloni P,Damiani E,Greci L,Wozniak M,Kulawiak D,Jankowski K,Kaczor J,Matuszkiewics Adoi
10.3109/10715769409056583subject
Has Abstractpub_date
1994-10-01 00:00:00pages
309-15issue
5eissn
1071-5762issn
1029-2470journal_volume
21pub_type
杂志文章abstract::Gastric inflammation is a highly complex biochemical protective response to cellular/tissue injury. When this process occurs in an uncontrolled manner, the result is excessive cellular/tissue damage that results chronic inflammation and destruction of normal tissue. Current evidence suggests that Helicobacter pylori (...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715760000301301
更新日期:2000-12-01 00:00:00
abstract::Exposure to asbestos fiber is central to mesothelial carcinogenesis. Recent sequencing studies on human and rodent malignant mesothelioma (MM) revealed frequently mutated genes, including CDKN2A, BAP1 and NF2. Crocidolite directly or indirectly catalyses the generation of hydroxyl radicals, which appears to be the maj...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1743285
更新日期:2020-03-01 00:00:00
abstract::Oxidative stress has been consistently linked to ageing-related neurodegenerative diseases. Neurodegenerative diseases are characterized by progressive dysfunction and death of neurons. Oxidative stress is associated with dysfunction of the mitochondria and endoplasmic reticulum, inducing apoptosis and protein misfold...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2011.574290
更新日期:2011-08-01 00:00:00
abstract::Prostaglandin E2 (PGE2) has been reported to play critical roles in cell fate decision by interacting with four types of prostanoid receptors such as EP1, EP2, EP3 and EP4. The present study was aimed at investigating the effect of the EP4-specific agonist CAY10598 in human colon cancer HCT116 cells. Our study reveale...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.951838
更新日期:2014-11-01 00:00:00
abstract::Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut industrial estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-gr...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.640676
更新日期:2012-01-01 00:00:00
abstract::We have here investigated possible occurrence of bicarbonate-dependent, carbonate radical anion (CO(3)(•-))-driven tocopherol-mediated human LDL peroxidation (TMP) in vitro and in vivo. CO(3)(•-), generated in vitro by the SOD1/H(2)O(2)/bicarbonate system, readily promoted TMP, which was dependent on α-tocopherol and ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.719613
更新日期:2012-11-01 00:00:00
abstract::Guanidinosuccinic acid (GSA) is noted for its nitric oxide (NO) mimicking actions such as vasodilatation and activation of the N-methyl-D-aspartate (NMDA) receptor. We have reported that GSA is the product of argininosuccinate (ASA) and some reactive oxygen species, mainly the hydroxyl radical. We tested for GSA synth...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300601
更新日期:1999-07-01 00:00:00
abstract::Weaning mice were fed a diet supplemented with beef tallow (BT) or BT plus docosahexaenoic acid (DHA) containing 100 mg alpha-tocopherol/kg (alpha-Toc100) or 500 mg alpha-tocopherol/kg (alpha-Toc500) for 4 wk to modify membrane fatty acid unsaturation, and then were administered ferric nitrilotriacetate (Fe-NTA). The ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300221
更新日期:1999-03-01 00:00:00
abstract::Effects of 12 wk exercise training on oxidative stress were examined in elderly humans. We measured oxidative stress during a 45 min cycling test by using antipyrine hydroxylation products. Antipyrine breakdown is independent of blood flow to the liver, which is important during exercise. Furthermore, antipyrine react...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300951
更新日期:2001-10-01 00:00:00
abstract::Soy sauce is a traditional fermented seasoning in Asian countries, that has high antioxidant activity in vitro and some antioxidant activity in vivo. We attempted to identify the major antioxidants present, using the 2,2'-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay as a guide. 3-Hydroxy-2-methyl-4H-p...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760601110871
更新日期:2007-04-01 00:00:00
abstract::Resorcinols (pentadecylresorcinol, olivetol, orcinol and resorcinol) exhibit antioxidant properties in liposomal systems. Antioxidant potency depends on the length of the alkyl chain. Pentadecylresorcinol has been demonstrated to be the most active antioxidant, indicating significance of its alkyl chain in a lipid bil...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769809070804
更新日期:1998-04-01 00:00:00
abstract::Peroxynitrous acid synthesized by reaction of hydrogen peroxide and nitrite and generated from 3-morpholinosydononimine (SIN-1) induced cellular DNA breaking of human promyelocytic leukemia HL-60 cells in phosphate buffer (pH 7.5) as assessed by alkaline single cell gel electrophoresis (comet) assay and quantification...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769900300031
更新日期:1999-01-01 00:00:00
abstract::Free radical oxidation of cholesterol and its precursors contribute significantly to the pathophysiology of a number of human diseases. This review intends to summarize recent developments and provide a perspective on the reactivities of sterols toward free radical oxidation, the free radical reaction mechanism, and t...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2014.985219
更新日期:2015-01-01 00:00:00
abstract::Nine male volunteers were given 36 g of cocoa powder (containing 2610 mg of polyphenols) per day with sugar and 6 volunteers received an equivalent amount of sugar for 2 weeks. Conjugated diene production in LDL induced by 2-2' azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) and copper ion were evaluated. The lag t...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300091
更新日期:2001-01-01 00:00:00
abstract::Proteins are subject to various posttranslational modifications, some of them being undesired from the point of view of metabolic efficiency. Prevention of such modifications is expected to provide new means of therapy of diseases and decelerate the process of aging. In this review, modifications of proteins by reacti...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2014.953494
更新日期:2014-11-01 00:00:00
abstract::The capacity of non-illuminated nephrotoxin orellanine ([2,2'-bipyridine]-3,3',4,4'-tetrol-1,1'-dioxide) to induce DNA damage in the presence of ferrous iron and dioxygen has been evaluated. Maximal single-strand breaks in plasmid DNA were obtained with a metal to ligand ratio 1:3. Instantaneous oxidation of Fe2+ in p...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000300681
更新日期:2000-08-01 00:00:00
abstract::Flavonoids, which are dietary components and have possible drug uses, inhibit lipoprotein oxidation in vitro. The present study considered whether flavonoid supplementation in humans could influence lipoprotein vulnerability to oxidation. Citrus flavonoid supplementation (about 1g/day, 3 weeks), or placebo, was given ...
journal_title:Free radical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/10715769900300341
更新日期:1999-04-01 00:00:00
abstract::Manganese superoxide dismutase (MnSOD) levels have been found to be low in human pancreatic cancer [Pancreas 26, (2003), 23] and human pancreatic cancer cell lines [Cancer Res. 63, (2003), 1297] when compared to normal human pancreas. We hypothesized that stable overexpression of pancreatic cancer cells with MnSOD cDN...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400017376
更新日期:2004-11-01 00:00:00
abstract::India, resembling other developing nations, is confronting a hastening demographic switch to non-communicable diseases. Inborn errors of metabolism (IEM) constitute a varied heterogeneous group of disorders with variable clinical appearance, primarily in the pediatric populace. Congenital deformities and genetic disor...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2021.1877286
更新日期:2021-01-27 00:00:00
abstract::Sonodynamic therapy, a promising new approach to cancer treatment, is based on synergistic cell killing by combination of certain drugs (sonosensitizers) and ultrasound. Although the mechanism of sonodynamic action is not understood, the role of free radicals produced from sonosensitizers by ultrasound is implicated. ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609145652
更新日期:1996-07-01 00:00:00
abstract::The concentration of taurine is high in the lens. However, its function therein remains unknown. Studies from other tissues suggest that in addition to several other modes of action, it acts as an antioxidant. We therefore hypothesize that taurine may be a part of the antioxidant defense mechanisms involved in protect...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769800300221
更新日期:1998-09-01 00:00:00
abstract::The radiation-induced reactions of a water-soluble coumarin derivative, coumarin-3-carboxyl acid (C3CA), have been investigated in aqueous solutions by pulse radiolysis with a 35 MeV electron beam, final product analysis following (60)Co γ-irradiations and deterministic model simulations. Pulse radiolysis revealed tha...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2012.684879
更新日期:2012-07-01 00:00:00
abstract::Reactive oxygen species (ROS) have been poised at a straddled state of being beneficiary as well detrimental depending on its threshold levels. Maintaining the homeostasis of ROS is imperative for normal cellular physiology, wherein physiological concentrations of ROS are involved in cell signaling and elevated ROS co...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.3109/10715762.2016.1155708
更新日期:2016-01-01 00:00:00
abstract::A glycomic approach to the identification of target molecules in glycosyltransferase gene targeting mice is a promising strategy to understand the biological significance of glycosyltransferase genes in vivo. In order to understand the biological effects of N-acetylglucosaminyltransferase III (GnT-III) on tumor format...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576021000005258
更新日期:2002-08-01 00:00:00
abstract::Adriamycin (ADR) is a chemotherapeutic agent useful in treating various cancers. ADR is a quinone-containing anthracycline chemotherapeutic and is known to produce reactive oxygen species (ROS) in heart. Application of this drug can have serious side effects in various tissues, including brain, apart from the known ca...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500143478
更新日期:2005-11-01 00:00:00
abstract::Capacitation of spermatozoa is an essential procedure for fertilization. Capacitated spermatozoa have an increase in the intracellular cAMP and acrosome reaction (AR) occurs immediately. The effect of exogenous superoxide anion (O2-) on the level of intracellular cAMP and the percentages of both spontaneous AR and lys...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609088023
更新日期:1996-04-01 00:00:00
abstract::To examine the involvement of p38 mitogen-activated protein kinase (p38 MAPK) and extracellular signal-regulated kinase (ERK) in the oxidative stress-induced increase of permeability in endothelial cells, the effects of a p38 MAPK inhibitor (SB203580) and ERK inhibitor (PD90859) on the H2O2-induced increase of permeab...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100301531
更新日期:2001-11-01 00:00:00
abstract::We have reported previously that the apparent rate of peroxynitrite (ONOO(-) ) decay, as followed from its absorbance at 302 nm, decreases in the presence of hydrogen peroxide, mannitol and ethanol (Alvarez et al., 1995, Chem. Res. Toxicol. 8:859-864; Alvarez et al., 1998, Free Radic. Biol. Med. 24:1331-1337). Recentl...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300411
更新日期:2001-05-01 00:00:00
abstract::Cystine, an oxidized form of cysteine (Cys), is imported into cells via the protein xCT, which is also associated with the export of glutamate as the counter amino acid. In the current study, we attempted to rationalize roles of xCT in the livers of male mice. While xCT was not expressed in the livers of ordinary mice...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1282157
更新日期:2017-01-01 00:00:00
abstract:BACKGROUND AND AIM:Previous studies have shown that preventive treatment with the antioxidant, ebselen, in experimental models of type 1 diabetic nephropathy resulted in an attenuation of structural and functional damage in the kidney. However, evidence for the effectiveness of ebselen in late-intervention studies is l...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2014.993628
更新日期:2015-03-01 00:00:00