Abstract:
:Resorcinols (pentadecylresorcinol, olivetol, orcinol and resorcinol) exhibit antioxidant properties in liposomal systems. Antioxidant potency depends on the length of the alkyl chain. Pentadecylresorcinol has been demonstrated to be the most active antioxidant, indicating significance of its alkyl chain in a lipid bilayer. Quantum DFT computations demonstrated that hydroxyl group attached to the ring is the first target for the hydrogen abstraction after formation of the radical. However, the carbons of the side chain could also participate in the antioxidant properties of the alkylresorcinols. Formation of the radical at the hydroxyl oxygen initiates changes in the electron density which destabilise the whole system and subsequently leads to oxidation of the ring. The detailed study of lipophilicity and electrostatic properties of resorcinols is discussed.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Hładyszowski J,Zubik L,Kozubek Adoi
10.3109/10715769809070804subject
Has Abstractpub_date
1998-04-01 00:00:00pages
359-68issue
4eissn
1071-5762issn
1029-2470journal_volume
28pub_type
杂志文章abstract::To examine local and systemic oxidative status of lung cancer (LC) and oxidant effects of radiotherapy (RT), this study evaluated antioxidants and markers of oxidative and nitrosative stress in bronchoalveolar lavage (BAL) fluid and in the blood of 36 LC patients and 36 non-cancer controls at baseline and during and a...
journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
pub_type: 杂志文章,评审
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journal_title:Free radical research
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journal_title:Free radical research
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doi:10.3109/10715762.2011.652627
更新日期:2012-03-01 00:00:00
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更新日期:2006-12-01 00:00:00
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