Abstract:
:This study evaluated the gender differences in response to intense exercise on lymphocyte hydrogen peroxide production, nitric oxide handling and mitochondrial superoxide dismutase (MnSOD) activity and gene expression. Fifteen males and nine females participated voluntarily in the study and performed a swimming session at 75-80% of the maximal capacity. In basal conditions females presented higher lymphocyte MnSOD activity compared to males (p<0.05). Exercise increased MnSOD activity in males (p<0.05) reaching similar values to females. MnSOD gene expression was also increased in males after exercise (p<0.05) but not in females. Nitrite concentration and iNOS gene expression significantly increased only in males after swimming (p<0.01). The exercise decreased UCP-3 gene expression in both genders (p<0.05). Lymphocyte H(2)O(2) production significantly increased in males after exercise in non-stimulated and in PMA-stimulated cells (p<0.01). In conclusion, females seem to be more protected against oxidative stress induced by a swimming session. Hydrogen peroxide is mainly produced in males and this subsequently leads to increases in MnSOD gene expression and activity.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Sureda A,Ferrer MD,Tauler P,Tur JA,Pons Adoi
10.1080/10715760801989926subject
Has Abstractpub_date
2008-04-01 00:00:00pages
312-9issue
4eissn
1071-5762issn
1029-2470pii
791856430journal_volume
42pub_type
杂志文章abstract::Paraquat is a synthetic bipyridylium salt widely used as herbicide and defoliant. Enzyme-catalyzed redoxcycling of paraquat generates oxygen radicals. The toxic, even lethal, effects of paraquat are due to free radical-mediated tissue injury. Ocular lesions, sometimes quite severe, have been observed following acciden...
journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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更新日期:1999-12-01 00:00:00
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journal_title:Free radical research
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doi:10.3109/10715769709097827
更新日期:1997-06-01 00:00:00
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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journal_title:Free radical research
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abstract::Cerebrovascular diseases (CBD) are one of the most dangerous complications of atherosclerosis. The clinical consequences of CBD deeply impact quality of life and the prognosis of patients. Atherosclerosis is the main cause of CBD development. Hypertension, dyslipidemia, diabetes, smoking, obesity, and other risk facto...
journal_title:Free radical research
pub_type: 杂志文章,评审
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更新日期:1998-07-01 00:00:00