Abstract:
:The impact of classic cardiovascular risk factors on oxidative stress status in a high-risk cardiovascular Mediterranean population of 527 subjects was estimated. Oxidative stress markers (malondialdehyde, 8-oxo-7'8'-dihydro-2'-deoxyguanosine, oxidized/reduced glutathione ratio) together with the activity of antioxidant enzyme triad (superoxide dismutase, catalase, glutathione peroxidase) were analysed in circulating mononuclear blood cells. Malondialdehyde, oxidized glutathione and the ratio of oxidized to reduced glutathione were significantly higher while catalase and glutathione peroxidase activities were significantly lower in high cardiovascular risk participants than in controls. Statistically significant differences were obtained after additional multivariate control for sex, age, obesity, diabetes, lipids and medications. Among the main cardiovascular risk factors, hypertension was the strongest determinant of oxidative stress in high risk subjects studied at a primary prevention stage.
journal_name
Free Radic Resjournal_title
Free radical researchauthors
Fandos M,Corella D,Guillén M,Portolés O,Carrasco P,Iradi A,Martínez-González MA,Estruch R,Covas MI,Lamuela-Raventós RM,Michavilla MT,Cerdá C,Torregrosa R,Redón J,Chaves FF,Tormos MC,Ocete D,Sáez GTdoi
10.3109/10715760903247231subject
Has Abstractpub_date
2009-12-01 00:00:00pages
1179-86issue
12eissn
1071-5762issn
1029-2470pii
10.3109/10715760903247231journal_volume
43pub_type
杂志文章abstract::The COST Action CM1201 "Biomimetic Radical Chemistry" has been active since December 2012 for 4 years, developing research topics organized into four working groups: WG1 - Radical Enzymes, WG2 - Models of DNA damage and consequences, WG3 - Membrane stress, signalling and defenses, and WG4 - Bio-inspired synthetic stra...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2016.1248961
更新日期:2016-11-01 00:00:00
abstract::Diet has been shown to modulate M(1)dG adduct, a biomarker of oxidative stress and lipid peroxidation. Thus, we analysed the association between diet and M(1)dG in 120 controls and 67 Map Ta Phut industrial estate workers in Rayong, Thailand, to evaluate the influence of fruit and vegetables, and fried and charcoal-gr...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.640676
更新日期:2012-01-01 00:00:00
abstract::Ischemia-reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), which contributes to the development of chronic kidney disease (CKD). IRI-induced AKI releases proinflammatory cytokines (e.g. IL-1β, TNF-α, IL-6) that induce a systemic inflammatory response, resulting in proinflammatory cells recruitm...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2019.1668936
更新日期:2019-10-01 00:00:00
abstract::It has been observed that H9c2 cardiac cells cultured in physiologic solutions exhibit delayed cell death after repeated medium replacements, of which the cause was the relatively mild osmotic challenges during the renewal of the culture medium. Interestingly, the cell damage was associated with altered intracellular ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760802691471
更新日期:2009-03-01 00:00:00
abstract::The interaction between the hydrophobic indolinonic nitroxide radical, 1,2-dihydro-2-methyl-2-phenyl-3H-indole-3-one-1-oxyl and hydrophilic alpha-, beta- and gamma-cyclodextrin derivatives was investigated in water by phase-solubility analysis. Among the studied cyclodextrins, random methyl-beta-cyclodextrin (RM-beta-...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400023689
更新日期:2005-01-01 00:00:00
abstract::The metabolism of paraquat generates oxygen radicals. Paraquat has thus been suggested as a model compound to induce oxidative damage to DNA, lipids and proteins in different cells and tissues, although experimental data are inconsistent. In order to explore the possibilities for an animal model of oxidative DNA damag...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760000300421
更新日期:2000-05-01 00:00:00
abstract::Cellular exposure to ionising radiation leads to oxidative stress events, which refer to elevated intracellular levels of reactive oxygen species (ROS). The elevated levels of ROS significantly contributed to γ-radiation (IR) induced cytotoxicity. In an attempt to minimise these cytotoxic effects, antioxidant compound...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2017.1395025
更新日期:2017-12-01 00:00:00
abstract::Testing of pregnant women reveals weakening of neutrophil-mediated effector functions, such as reactive oxygen species generation. This study provides data confirming the phenomenon, gained through application of the flow cytometry technique. Key factors influencing neutrophil functional activity in blood plasma of pr...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2016.1197395
更新日期:2016-08-01 00:00:00
abstract::We evaluated whether nutritional vitamin A deficiency generates oxidative stress and inflammation in aorta. Wistar male rats (21 days old) were given free access to a control (8 mg retinol as retinyl palmitate/kg) or a vitamin A- deficient diet for three months. One group of deficient animals was fed with the control ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500072214
更新日期:2005-06-01 00:00:00
abstract:BACKGROUND:Although cis-diamminedichloroplatinum (II) (cisplatin) is an effective anticancer agent, its clinical use is highly limited predominantly due to its adverse effects on renal functions. The present work examined the therapeutic potential of edaravone, a free radical scavenger, for inhibiting cisplatin-induced...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001646886
更新日期:2004-04-01 00:00:00
abstract::It is well known that reperfusion damage of ischemic myocardium may be attributed to alterations in the antioxidant defense system against free radical aggression. In addition, the degree of myocardial damage may depend on the duration and severity of ischemia that precedes reperfusion. We carried out serial ischemic ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769409147514
更新日期:1994-03-01 00:00:00
abstract::Peroxynitrite anion is a reactive and short-lived species and its formation in vivo has been implicated in several human diseases. In view of the potential usefulness of compounds that can protect against peroxynitrite or their reactive intermediates, a study focused on flavonoid compounds was carried out. Since the r...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760400003384
更新日期:2004-09-01 00:00:00
abstract::Retinal mitochondria become dysfunctional in diabetes and the production of superoxide radicals is increased; over-expression of MnSOD abrogates mitochondrial dysfunction and prevents the development of diabetic retinopathy. The mitochondrial DNA (mtDNA) is particularly prone to oxidative damage. The aim of this study...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715760903494168
更新日期:2010-03-01 00:00:00
abstract::Liver microsomal functions related to xenobiotic biotransformation and free radical production were studied in control rats and in animals subjected to L-3,3',5-triiodothyronine (T3) and/or lindane administration as possible mechanisms contributing to oxidative stress, in relation to the activity of enzymes (superoxid...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715769800300051
更新日期:1998-07-01 00:00:00
abstract::Reperfusion injury of the liver occurs in liver transplantation and in major hepatectomies. It triggers a severe oxidative stress that leads to increased lipid peroxidation. In our study we examined the effect of parenteral supranutritional administration of alpha-tocopherol, a vitamin that plays a key role in the end...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100300641
更新日期:2001-08-01 00:00:00
abstract::2,5,7,8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman (alpha-CEHC) has been identified as a major water-soluble metabolite of vitamin E, which circulates in the blood and is excreted with the urine. The aim of this study was to assess the antioxidant activity of alpha-CEHC using several methods with different proox...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/1071576021000005357
更新日期:2002-08-01 00:00:00
abstract::The phenomenon of ozone tolerance is described, but the underlying mechanisms remain unknown. We tested whether adaptation to multiday ozone exposure was related to an upregulated pulmonary antioxidant defence. Six calves were exposed to 0.75 ppm ozone, 12 h day(-1) for seven consecutive days. Pulmonary function tests...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760210169
更新日期:2002-01-01 00:00:00
abstract::In aerobes, oxygen is essential for maintenance of life. However, incomplete reduction of oxygen leads to generation of reactive oxygen species. These oxidants oxidise biological macromolecules present in their vicinity and thereby impair cellular functions causing oxidative stress (OS). Aerobes have evolved both enzy...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2019.1702656
更新日期:2020-01-01 00:00:00
abstract::It is well known that reactive oxygen species (ROS) attack several living tissues and increase the risk of development and progression of serious diseases. In neuronal level, ROS induce cell death in concentration-dependent fashion. However, little is known about the mechanisms of neuronal changes by ROS prior to indu...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2011.647689
更新日期:2012-02-01 00:00:00
abstract::Uraemic subjects undergoing chronic haemodialysis show increased oxidative stress. The use of non-biocompatible filters and reduced antioxidative defences are important sources of reactive oxygen species (ROS) release. The highly oxidative environment accelerates the onset and progression of tissue damage and atherosc...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760500445121
更新日期:2006-02-01 00:00:00
abstract::Flavonoids, which are dietary components and have possible drug uses, inhibit lipoprotein oxidation in vitro. The present study considered whether flavonoid supplementation in humans could influence lipoprotein vulnerability to oxidation. Citrus flavonoid supplementation (about 1g/day, 3 weeks), or placebo, was given ...
journal_title:Free radical research
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1080/10715769900300341
更新日期:1999-04-01 00:00:00
abstract::Over the last decade, a dual character of cell response to oxidative stress, eustress versus distress, has become increasingly recognized. A growing body of evidence indicates that under physiological conditions, low concentrations of reactive oxygen and nitrogen species (RONS) maintained by the activity of endogenous...
journal_title:Free radical research
pub_type: 杂志文章,评审
doi:10.1080/10715762.2018.1457217
更新日期:2018-05-01 00:00:00
abstract::Generation of toxic oxygen metabolites followed by oxidant- and inflammatory-mediated tissue injury plays a crucial role in the pathogenesis of ischemia and reperfusion (IR). Ubiquinol, the reduced form of coenzyme Q10, is recognized for its potent antioxidant and anti-inflammatory properties in biological membranes. ...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715762.2013.858148
更新日期:2014-02-01 00:00:00
abstract::Sublytic levels (microM) of hemin destabilized RBC membrane as indicated by ghost fragmentation pattern using a laser viscodiffractometer. Furthermore, electron microscopic study shows that 5 microM of hemin induced echinocytic transformation whereas higher hemin concentration (40 microM) induced spherocytic transform...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769709097838
更新日期:1997-07-01 00:00:00
abstract::The in vitro toxicity of the reactive oxygen species generating enzyme xanthine oxidoreductase (XOR) to human peripheral blood lymphocytes was studied after stimulation with phytohaemoagglutinin or anti-CD3/CD28 antibodies. Apoptosis and necrosis were induced by the XOR/hypoxanthine system in a time- and concentration...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760100301191
更新日期:2001-12-01 00:00:00
abstract::We investigated effect of aldehydic products of lipid peroxidation, malondialdehyde (MDA) and 4-hydroxynonenal (HNE) on prostaglandin (PG) E2 receptors of liver plasma membranes. The modification of the membranes by MDA diminished PGE2 binding, decreasing receptor affinity for PGE2 and receptor density whereas HNE inc...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.3109/10715769609149064
更新日期:1996-11-01 00:00:00
abstract::The translocation of transcription factor EB (TFEB) to the nucleus plays a pivotal role in the regulation of basic cellular processes, such as lysosome biogenesis and autophagy. Autophagy is an intracellular degradation system that delivers cytoplasmic constituents to the lysosome, which is important in maintaining ce...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1791843
更新日期:2020-07-28 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the most common form of lung cancer. Radioresistance is a significant obstacle in NSCLC radiotherapy. Long non-coding RNA LINC00473 has been found to impact the radiotherapy in several malignant tumours. This study aimed to investigate the underlying role and mechanism of LINC0047...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2020.1841900
更新日期:2020-10-01 00:00:00
abstract::A soluble protein from Saccharomyces cerevisiae acts as a peroxidase but requires a NADPH-dependent thioredoxin system and was named thioredoxin peroxidase (TPx). The role of TPx in aging of stationary cultures of S. cerevisiae was investigated in a wild-type strain and a mutant yeast strain in which the tsa gene that...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715760310001649009
更新日期:2004-03-01 00:00:00
abstract::G72 has been characterised as a susceptibility gene that can have wide-ranging effects in a number of neurodegenerative diseases, including schizophrenia and major depression. Indeed, its product, pLG72, is a potential serum biomarker for schizophrenia. Previous transcriptomic and biochemical studies have indicated th...
journal_title:Free radical research
pub_type: 杂志文章
doi:10.1080/10715762.2018.1504293
更新日期:2018-09-01 00:00:00