Metabolism of 6-aminonicotinic acid in Escherichia coli.

Abstract:

:A late-log-phase culture of an Escherichia coli nadB pncA double mutant took up 6-[7-14C]aminonicotinic acid and excreted 6-[14C]aminonicotinamide. This mutant also accumulated intracellularly several radioactive compounds which have been tentatively identified as 6-amino analogs of compounds in the pyridine nucleotide cycle. It is concluded that 6-aminonicotinamide and 6-aminonicotinic acid probably exert at least a portion of their bacteriostatic effects by being metabolized, by the enzymes of the pyridine nucleotide cycle, to 6-aminonicotinamide adenine dinucleotide and 6-aminonicotinamide adenine dinucleotide phosphate. These compounds are not electron acceptors and are known inhibitors of some pyridine nucleotide-linked dehydrogenases.

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Cobb JR,Pearcy SC,Gholson RK

doi

10.1128/JB.131.3.789-794.1977

subject

Has Abstract

pub_date

1977-09-01 00:00:00

pages

789-94

issue

3

eissn

0021-9193

issn

1098-5530

journal_volume

131

pub_type

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