abstract：:Acinetobacter baumannii is a severe threat to human health as a frequently multidrug-resistant hospital-acquired pathogen. Part of the danger from this bacterium comes from its genome plasticity and ability to evolve quickly by taking up and recombining external DNA into its own genome in a process called natural comp...

journal_title：Journal of bacteriology

authors： Vesel N,Blokesch M

更新日期：2021-01-25 00:00:00

abstract：:The gut microbiota plays a crucial role in the development of the immune system and confers benefits or disease susceptibility to the host. Emerging studies have indicated the gut microbiota could affect pulmonary health and disease through cross talk between the gut microbiota and the lungs. Gut microbiota dysbiosis c...

journal_title：Journal of bacteriology

authors： Zhou A,Lei Y,Tang L,Hu S,Yang M,Wu L,Yang S,Tang B

更新日期：2021-01-25 00:00:00

abstract：:Lysozyme is an important component of the innate immune system. It functions by hydrolyzing the peptidoglycan (PG) layer of bacteria. The human pathogen Listeria monocytogenes is intrinsically lysozyme resistant. The peptidoglycan N-deacetylase PgdA and O-acetyltransferase OatA are two known factors contributing to it...

journal_title：Journal of bacteriology

authors： Rismondo J,Schulz LM,Yacoub M,Wadhawan A,Hoppert M,Dionne MS,Gründling A

更新日期：2021-01-25 00:00:00

abstract：:Members of Thermococcales harbor a number of genes encoding putative aminotransferase Class III enzymes. Here, we characterized the TK1211 protein from the hyperthermophilic archaeon Thermococcus kodakarensis The TK1211 gene was expressed in T. kodakarensis under the control of the strong, constitutive promoter of the...

journal_title：Journal of bacteriology

authors： Zheng RC,Lu XF,Tomita H,Hachisuka SI,Zheng YG,Atomi H

更新日期：2021-01-19 00:00:00

abstract：:Current mouse models for evaluating the efficacy of live oral cholera vaccines (OCVs) have important limitations. Conventionally raised adult mice are resistant to intestinal colonization by Vibrio cholerae, but germfree mice can be colonized and have been used to study OCV immunogenicity. However, germfree animals ha...

journal_title：Journal of bacteriology

authors： Fakoya B,Sit B,Waldor MK

更新日期：2020-11-19 00:00:00

abstract：:Cyclic di-AMP (c-di-AMP) is an essential and ubiquitous second messenger among bacteria. c-di-AMP regulates many cellular pathways through direct binding to several molecular targets in bacterial cells. c-di-AMP depletion is well known to destabilize the bacterial cell wall, resulting in increased bacteriolysis and en...

journal_title：Journal of bacteriology

authors： Massa SM,Sharma AD,Siletti C,Tu Z,Godfrey JJ,Gutheil WG,Huynh TN

更新日期：2020-11-19 00:00:00

abstract：:Fluctuations in osmolarity are one of the most prevalent stresses to which bacteria must adapt, both hypo- and hyperosmotic conditions. Most bacteria cope with high osmolarity by accumulating compatible solutes (osmolytes) in the cytoplasm to maintain the turgor pressure of the cell. Vibrio parahaemolyticus, a halophi...

journal_title：Journal of bacteriology

authors： Gregory GJ,Dutta A,Parashar V,Boyd EF

更新日期：2020-11-19 00:00:00

abstract：:Many pathogenic bacteria translocate virulence factors into their eukaryotic hosts by means of type IV secretion systems (T4SS) spanning the inner and outer membranes. Genes encoding components of these systems have been identified within the order Rickettsiales based upon their sequence similarities to other prototyp...

journal_title：Journal of bacteriology

authors： Crosby FL,Munderloh UG,Nelson CM,Herron MJ,Lundgren AM,Xiao YP,Allred DR,Barbet AF

更新日期：2020-11-04 00:00:00

abstract：:Streptococcus agalactiae (group B streptococcus [GBS]) is a major cause of infections in newborns, pregnant women, and immunocompromised patients. GBS strain CNCTC10/84 is a clinical isolate that has high virulence in animal models of infection and has been used extensively to study GBS pathogenesis. Two unusual featu...

journal_title：Journal of bacteriology

authors： Zhu L,Beres SB,Yerramilli P,Pruitt L,Cantu CC,Olsen RJ,Musser JM

更新日期：2020-11-04 00:00:00

abstract：:Burkholderia thailandensis is a soil saprophyte that is closely related to the pathogen Burkholderia pseudomallei, the etiological agent of melioidosis in humans. The environmental niches and infection sites occupied by these bacteria are thought to contain only limited concentrations of oxygen, where they can generat...

journal_title：Journal of bacteriology

authors： Vitale A,Paszti S,Takahashi K,Toyofuku M,Pessi G,Eberl L

更新日期：2020-11-04 00:00:00

abstract：:Bacteria commonly live in dense polymicrobial communities and compete for scarce resources. Consequently, they employ a diverse array of mechanisms to harm, inhibit and kill their competitors. The cell wall is essential for bacterial survival by providing mechanical strength to resist osmotic stress. Because peptidogl...

journal_title：Journal of bacteriology

authors： Sibinelli-Sousa S,Hespanhol JT,Bayer-Santos E

更新日期：2020-11-02 00:00:00

abstract：:Phosphate is an essential nutrient that Staphylococcus aureus and other pathogens must acquire from the host during infection. While inorganic monophosphate (Pi) is the preferred source of this nutrient, bacteria can also obtain it from phosphate-containing organic molecules. The Pi-responsive regulator PhoPR is neces...

journal_title：Journal of bacteriology

authors： Kelliher JL,Leder Macek AJ,Grudzinski KM,Radin JN,Kehl-Fie TE

更新日期：2020-10-22 00:00:00

abstract：:Pseudomonas aeruginosa isolates from chronic lung infections often overproduce alginate, giving rise to the mucoid phenotype. Isolation of mucoid strains from chronic lung infections correlates with a poor patient outcome. The most common mutation that causes the mucoid phenotype is called mucA22 and results in a trun...

journal_title：Journal of bacteriology

authors： Cross AR,Raghuram V,Wang Z,Dey D,Goldberg JB

更新日期：2020-09-23 00:00:00

abstract：:Mycoplasma ovipneumoniae belongs to Mycoplasma, a genus containing the smallest self-replicating microorganisms, and causes infectious pleuropneumonia in goats and sheep. Nucleotide-binding oligomerization domain-containing protein (NOD2), an intracellular pattern recognition receptor, interacts with muramyl dipeptide...

journal_title：Journal of bacteriology

authors： Luo H,Wu X,Xu Z,Hao X,Wang Y,Li M

更新日期：2020-09-23 00:00:00

abstract：:Chlamydia trachomatis lacks the canonical genes required for the biosynthesis of p-aminobenzoate (pABA), a component of essential folate cofactors. Previous studies revealed a single gene from C. trachomatis, the CT610 gene, that rescues Escherichia coli ΔpabA, ΔpabB, and ΔpabC mutants, which are otherwise auxotrophic...

journal_title：Journal of bacteriology

authors： Macias-Orihuela Y,Cast T,Crawford I,Brandecker KJ,Thiaville JJ,Murzin AG,de Crécy-Lagard V,White RH,Allen KD

更新日期：2020-09-23 00:00:00

abstract：:Bdellovibrio bacteriovorus is an obligate predatory bacterium that invades and kills a broad range of Gram-negative prey cells, including human pathogens. Its potential therapeutic application has been the subject of increased research interest in recent years. However, an improved understanding of the fundamental mol...

journal_title：Journal of bacteriology

authors： Bukowska-Faniband E,Andersson T,Lood R

更新日期：2020-08-25 00:00:00

abstract：:Microorganisms and plants utilize two-component systems to regulate adaptive responses to changing environmental conditions. Sensor kinases detect stimuli and alter their autophosphorylation activity accordingly. Signal propagation occurs via the transfer of phosphoryl groups from upstream kinases to downstream respon...

journal_title：Journal of bacteriology

authors： Straughn PB,Vass LR,Yuan C,Kennedy EN,Foster CA,Bourret RB

更新日期：2020-07-09 00:00:00

abstract：:In Enterococcus faecalis, the site 2 protease Eep generates sex pheromones, including cAM373. Intriguingly, in Staphylococcus aureus, a peptide similar to cAM373, named cAM373_SA, is produced from the camS gene. Here, we report that the staphylococcal Eep homolog is not only responsible for the production of cAM373_SA...

journal_title：Journal of bacteriology

authors： Cheng D,Lv H,Yao Y,Cheng S,Huang Q,Wang H,Liu X,Bae T,Li M,Liu Q

更新日期：2020-07-09 00:00:00

abstract：:Group A streptococcus (GAS) produces millions of infections worldwide, including mild mucosal infections, postinfection sequelae, and life-threatening invasive diseases. During infection, GAS readily acquires nutritional iron from host heme and hemoproteins. Here, we identified a new heme importer, named SiaFGH, and i...

journal_title：Journal of bacteriology

authors： Chatterjee N,Cook LCC,Lyles KV,Nguyen HAT,Devlin DJ,Thomas LS,Eichenbaum Z

更新日期：2020-06-25 00:00:00

abstract：:Correct targeting of membrane proteins is essential for membrane integrity, cell physiology, and viability. Cotranslational targeting depends on the universally conserved signal recognition particle (SRP), which is a ribonucleoprotein complex comprised of the protein component Ffh and the 4.5S RNA in Escherichia coli ...

journal_title：Journal of bacteriology

authors： Sauerbrei B,Arends J,Schünemann D,Narberhaus F

更新日期：2020-06-25 00:00:00

abstract：:Sneathia amnii is a poorly characterized emerging pathogen that has been implicated in amnionitis and urethritis. We found that S. amnii damages fetal membranes, and we identified and purified a cytotoxic exotoxin that lyses human red blood cells and damages cells from fetal membranes. The gene appears to be cotranscr...

journal_title：Journal of bacteriology

authors： Gentile GL,Rupert AS,Carrasco LI,Garcia EM,Kumar NG,Walsh SW,Jefferson KK

更新日期：2020-06-09 00:00:00

abstract：:Bacterial carboxyl-terminal processing proteases (CTPs) are widely conserved and have been linked to important processes including signal transduction, cell wall metabolism, and virulence. However, the features that target proteins for CTP-dependent cleavage are unclear. Studies of the Escherichia coli CTP Prc suggest...

journal_title：Journal of bacteriology

authors： Chung S,Darwin AJ

更新日期：2020-06-01 00:00:00

abstract：:Listeria monocytogenes is a model facultative intracellular pathogen. Tight regulation of virulence proteins is essential for a successful infection, and the gene encoding the annotated thioredoxin YjbH was identified in two forward genetic screens as required for virulence factor production. Accordingly, an L. monocy...

journal_title：Journal of bacteriology

authors： Ruhland BR,Reniere ML

更新日期：2020-05-27 00:00:00

abstract：:Bacteriocins are ribosomally synthesized proteinaceous antibacterial peptides. They selectively interfere with the growth of other bacteria. The production and secretion of bacteriocins confer a distinct ecological advantage to the producer in competing against other bacteria that are present in the same ecological ni...

journal_title：Journal of bacteriology

authors： Dufour D,Barbour A,Chan Y,Cheng M,Rahman T,Thorburn M,Stewart C,Finer Y,Gong SG,Lévesque CM

更新日期：2020-05-27 00:00:00

abstract：:CRISPR-Cas systems are prokaryotic adaptive immune systems that facilitate protection of bacteria and archaea against infection by external mobile genetic elements. The model pathogen Francisella novicida encodes a CRISPR-Cas12a (FnoCas12a) system and a CRISPR-Cas9 (FnoCas9) system, the latter of which has an addition...

journal_title：Journal of bacteriology

authors： Ratner HK,Weiss DS

更新日期：2020-05-27 00:00:00

abstract：:Streptococcus pyogenes, or group A Streptococcus (GAS), is both a pathogen and an asymptomatic colonizer of human hosts and produces a large number of surface-expressed and secreted factors that contribute to a variety of infection outcomes. The GAS-secreted cysteine protease SpeB has been well studied for its effects...

journal_title：Journal of bacteriology

authors： Carothers KE,Liang Z,Mayfield J,Donahue DL,Lee M,Boggess B,Ploplis VA,Castellino FJ,Lee SW

更新日期：2020-05-11 00:00:00

abstract：:In Listeria monocytogenes, the full details of how stress signals are integrated into the σB regulatory pathway are not yet available. To help shed light on this question, we investigated a collection of transposon mutants that were predicted to have compromised activity of the alternative sigma factor B (σB). These m...

journal_title：Journal of bacteriology

authors： Guerreiro DN,Wu J,Dessaux C,Oliveira AH,Tiensuu T,Gudynaite D,Marinho CM,Boyd A,García-Del Portillo F,Johansson J,O'Byrne CP

更新日期：2020-04-09 00:00:00

abstract：:Cystic fibrosis (CF) patients chronically infected with both Pseudomonas aeruginosa and Staphylococcus aureus have worse health outcomes than patients who are monoinfected with either P. aeruginosa or S. aureus We showed previously that mucoid strains of P. aeruginosa can coexist with S. aureusin vitro due to the tran...

journal_title：Journal of bacteriology

authors： Price CE,Brown DG,Limoli DH,Phelan VV,O'Toole GA

更新日期：2020-03-26 00:00:00

abstract：:The Gram-negative pathogen Neisseria gonorrhoeae (gonococcus [Gc]) colonizes lysozyme-rich mucosal surfaces. Lysozyme hydrolyzes peptidoglycan, leading to bacterial lysis. Gc expresses two proteins, SliC and NgACP, that bind and inhibit the enzymatic activity of lysozyme. SliC is a surface-exposed lipoprotein, while N...

journal_title：Journal of bacteriology

authors： Ragland SA,Gray MC,Melson EM,Kendall MM,Criss AK

更新日期：2020-03-26 00:00:00

abstract：:Transition metals are essential for life but are toxic when in excess. Metal ion intoxication may result from the mismetallation of essential metal-dependent enzymes with a noncognate metal. To begin to identify enzymes and processes that are susceptible to mismetallation, we have selected for strains with increased r...

journal_title：Journal of bacteriology

authors： Pi H,Wendel BM,Helmann JD

更新日期：2020-03-11 00:00:00

abstract：:Exoelectrogens are able to transfer electrons extracellularly, enabling them to respire on insoluble terminal electron acceptors. Extensively studied exoelectrogens, such as Geobacter sulfurreducens and Shewanella oneidensis, are Gram negative. More recently, it has been reported that Gram-positive bacteria, such as L...

journal_title：Journal of bacteriology

authors： Jeuken LJC,Hards K,Nakatani Y

更新日期：2020-03-11 00:00:00

abstract：:The marine bacterium and human pathogen Vibrio parahaemolyticus rapidly colonizes surfaces by using swarming motility and forming robust biofilms. Entering one of the two colonization programs, swarming motility or sessility, involves differential regulation of many genes, resulting in a dramatic shift in physiology a...

journal_title：Journal of bacteriology

authors： Kimbrough JH,Cribbs JT,McCarter LL

更新日期：2020-02-25 00:00:00

abstract：:Bradyrhizobium diazoefficiens is a soil alphaproteobacterium that possesses two evolutionarily distinct flagellar systems, a constitutive subpolar flagellum and inducible lateral flagella that, depending on the carbon source, may be expressed simultaneously in liquid medium and used interactively for swimming. In each...

journal_title：Journal of bacteriology

authors： Mengucci F,Dardis C,Mongiardini EJ,Althabegoiti MJ,Partridge JD,Kojima S,Homma M,Quelas JI,Lodeiro AR

更新日期：2020-02-11 00:00:00

abstract：:The bacterial flagellum is a biological nanomachine that rotates to allow bacteria to swim. For flagellar rotation, torque is generated by interactions between a rotor and a stator. The stator, which is composed of MotA and MotB subunit proteins in the membrane, is thought to bind to the peptidoglycan (PG) layer, whic...

journal_title：Journal of bacteriology

authors： Zhu S,Nishikino T,Takekawa N,Terashima H,Kojima S,Imada K,Homma M,Liu J

更新日期：2020-01-29 00:00:00

abstract：:Evolutionary trajectories and mutational landscapes of drug-resistant bacteria are influenced by cell-intrinsic and extrinsic factors. In this study, I demonstrated that loss of the Lon protease altered susceptibility of Escherichia coli to trimethoprim and that these effects were strongly contingent on the drug conce...

journal_title：Journal of bacteriology

authors： Matange N

更新日期：2020-01-15 00:00:00

abstract：:In all organisms, chromosome replication is regulated mainly at the initiation step. Most of the knowledge about the mechanisms that regulate replication initiation in bacteria has come from studies on rod-shaped bacteria, such as Escherichia coli and Bacillus subtilisStreptomyces is a bacterial genus that is characte...

journal_title：Journal of bacteriology

authors： Łebkowski T,Wolański M,Ołdziej S,Flärdh K,Zakrzewska-Czerwińska J

更新日期：2020-01-15 00:00:00

abstract：:The anaerobic spore former Clostridioides difficile causes significant diarrheal disease in humans and other mammals. Infection begins with the ingestion of dormant spores, which subsequently germinate within the host gastrointestinal tract. There, the vegetative cells proliferate and secrete two exotoxins, TcdA and T...

journal_title：Journal of bacteriology

authors： Edwards AN,Krall EG,McBride SM

更新日期：2020-01-02 00:00:00

abstract：:In Escherichia coli and Salmonella, the c-di-GMP effector YcgR inhibits flagellar motility by interacting directly with the motor to alter both its bias and speed. Here, we demonstrate that in both of these bacteria, YcgR acts sequentially, altering motor bias first and then decreasing motor speed. We show that when c...

journal_title：Journal of bacteriology

authors： Nieto V,Partridge JD,Severin GB,Lai RZ,Waters CM,Parkinson JS,Harshey RM

更新日期：2019-12-06 00:00:00

abstract：:The glpD (MSMEG_6761) gene encoding glycerol-3-phosphate dehydrogenase was shown to be crucial for M. smegmatis to utilize glycerol as the sole carbon source. The glpD gene likely forms the glpFKD operon together with glpF and glpK, encoding a glycerol facilitator and glycerol kinase, respectively. The gylR (MSMEG_675...

journal_title：Journal of bacteriology

authors： Bong HJ,Ko EM,Song SY,Ko IJ,Oh JI

更新日期：2019-11-20 00:00:00

abstract：:Transcriptomic, metabolomic, physiological, and computational modeling approaches were integrated to gain insight into the mechanisms of antibiotic tolerance in an in vitro biofilm system. Pseudomonas aeruginosa biofilms were grown in drip flow reactors on a medium composed to mimic the exudate from a chronic wound. A...

journal_title：Journal of bacteriology

authors： Stewart PS,White B,Boegli L,Hamerly T,Williamson KS,Franklin MJ,Bothner B,James GA,Fisher S,Vital-Lopez FG,Wallqvist A

更新日期：2019-10-21 00:00:00