Abstract：
:Duchenne muscular dystrophy (DMD) is secondary to loss-of-function mutations in the dystrophin gene. The causes underlying the progression of DMD, differential muscle involvement, and the discrepancies in phenotypes among species with the same genetic defect are not understood. The mdx mouse, an animal model with dystrophin mutation, has a milder phenotype. This article reviews the available information on expression of signaling-related molecules in DMD and mdx. Extracellular matrix proteoglycans, growth factors, integrins, caveolin-3, and neuronal nitric oxide synthase expression do not show significant differences. Calcineurin is inconsistently activated in mdx. which is associated with lack of cardiomyopathy, compared to the permanent calcineurin activation in mdx/utrophin null mice that have a DMD-like cardiomyopathy. Levels of focal adhesion kinase (FAK) and extracellular regulated kinases (ERKs) differ among mdx and DMD. Further work is needed to identify the point of discrepancy in these signaling molecules' pathways in dystrophynopathies.
journal_name
Biol Resjournal_title
Biological researchauthors
Fadic Rdoi
10.4067/s0716-97602005000400010keywords:
subject
Has Abstractpub_date
2005-01-01 00:00:00pages
375-80issue
4eissn
0716-9760issn
0717-6287pii
S0716-97602005000400010journal_volume
38pub_type
杂志文章,评审abstract：:The electrophysiological properties of neurons are determined by the expression of defined complements of ion channels. Nonetheless, the regulation mechanisms of the expression of neuronal ion channels are poorly understood, due in part to the diversity of neuron subtypes. We explored the expression of voltage-gated c...
journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602006000300010
更新日期：2006-01-01 00:00:00
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pub_type： 杂志文章
doi：10.4067/s0716-97602006000100012
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doi：10.1186/0717-6287-47-40
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journal_title：Biological research
pub_type： 杂志文章,评审
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更新日期：2007-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
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pub_type： 杂志文章
doi：10.1186/0717-6287-47-41
更新日期：2014-09-05 00:00:00
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更新日期：2020-10-20 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/0717-6287-47-11
更新日期：2014-04-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602005000100007
更新日期：2005-01-01 00:00:00
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更新日期：2019-12-23 00:00:00
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更新日期：2015-11-17 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1996-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602001000100012
更新日期：2001-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602002000100011
更新日期：2002-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602009000100013
更新日期：2009-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602004000400017
更新日期：2004-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2015-10-13 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1995-01-01 00:00:00
abstract：:Guanine nucleotide binding proteins (GTP-binding proteins) function as transducers of signals in different cellular processes. We have identified several GTP-binding proteins in Trypanosoma cruzi by Western blot analyses. Six polypeptide bands, p20, p25, p28, p31, p37 and p38, were specifically detected in epimastigot...
journal_title：Biological research
pub_type： 杂志文章
doi：
更新日期：1993-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：/S0716-97602010000200013
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:miR-214 was demonstrated to be upregulated in models of renal disease and promoted fibrosis in renal injury independent of TGF-β signaling in vivo. However, the detailed role of miR-214 in acute kidney injury (AKI) and its underlying mechanism are still largely unknown. METHODS:In this study, an I/R-induced...
journal_title：Biological research
pub_type： 杂志文章
doi：10.1186/s40659-018-0179-2
更新日期：2018-09-04 00:00:00
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journal_title：Biological research
pub_type： 杂志文章
doi：10.4067/s0716-97602001000200010
更新日期：2001-01-01 00:00:00
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journal_title：Biological research
pub_type： 杂志文章,评审
doi：
更新日期：1998-01-01 00:00:00
