Fitness of Japanese encephalitis virus to Neuro-2a cells is determined by interactions of the viral envelope protein with highly sulfated glycosaminoglycans on the cell surface.

abstract：:Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...

journal_title：Journal of medical virology

authors： Yoshizaki T,Wakisaka N,Kondo S,Murono S,Shimizu Y,Nakashima M,Tsuji A,Furukawa M

更新日期：2008-05-01 00:00:00

abstract：:Responses to influenza vaccination are poor in frail elderly subjects who suffer the greatest morbidity and mortality due to infection. Therefore, a randomized clinical trial was performed to determine the effect of a double dose and booster vaccination on antibody responses after influenza vaccination. A total of 815...

journal_title：Journal of medical virology

authors： Roos-Van Eijndhoven DG,Cools HJ,Westendorp RG,Ten Cate-Hoek AJ,Knook DL,Remarque EJ

更新日期：2001-04-01 00:00:00

abstract：:In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...

journal_title：Journal of medical virology

authors： Coulombié FC,Alché LE,Lampuri JS,Coto CE

更新日期：1986-03-01 00:00:00

abstract：:To define better the human immune response to individual structural proteins of human cytomegalovirus (HCMV), 55 human sera with different IgG and IgM titres were studied for their reactivity with HCMV structural polypeptides separated by SDS-PAGE and electrotransferred to nitrocellulose paper. The results obtained sh...

journal_title：Journal of medical virology

authors： Landini MP,Re MC,Mirolo G,Baldassarri B,La Placa M

更新日期：1985-12-01 00:00:00

abstract：:Sera from 1,943 individuals from Auckland, New Zealand, were tested for the presence of serum antibodies to human T cell lymphotropic virus I (HTLV I), mainly with an enzyme-linked immunosorbent assay (ELISA) with cell extracts as target antigen. The individuals tested were blood donors and mostly Caucasian, but inclu...

journal_title：Journal of medical virology

authors： Reddy D,Okochi K,Woodfield DG,Judd W

更新日期：1987-08-01 00:00:00

abstract：:This study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a group of patients co-infected with HIV and hepatitis B virus (HBV). A cross-sectional study of 847 patients with HIV was conducted. Patients provided blood samples for HBsAg detection. The load...

journal_title：Journal of medical virology

authors： Mendes-Correa MC,Pinho JR,Locarnini S,Yuen L,Sitnik R,Santana RA,Gomes-Gouvêa MS,Leite OM,Martins LG,Silva MH,Gianini RJ,Uip DE

更新日期：2010-09-01 00:00:00

abstract：:Nutrient starvation is a common phenomenon that occurs during T cell activation. Upon pathogen infection, large amounts of immune cells migrate to infection sites, and antigen-specific T cells are activated; this is followed by rapid proliferation through clonal expansion. The dramatic expansion of cells will commonly...

journal_title：Journal of medical virology

authors： Lu J,Jia J,Zhang J,Liu X

更新日期：2020-08-13 00:00:00

abstract：:To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneous...

journal_title：Journal of medical virology

authors： Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G

更新日期：1995-04-01 00:00:00

abstract：:An enzyme immunoassay utilizing a fluorogenic substrate (EIFA) was employed to compare humoral antibody responses to purified virion and dense body antigens in human cytomegalovirus (CMV) infections. Results of these antibody assays were also compared to those obtained by plaque reduction neutralization and complement...

journal_title：Journal of medical virology

authors： Forghani B,Schmidt NJ

更新日期：1980-01-01 00:00:00

abstract：:Human parechoviruses (HPeVs) infection is associated with a wide range of clinical syndromes such as respiratory, gastrointestinal, neurologic diseases, and neonatal sepsis-like illness. The main objective of this study was to investigate the epidemiology of HPeVs infection in hospitalized patients in a period of 2 ye...

journal_title：Journal of medical virology

authors： Piralla A,Furione M,Rovida F,Marchi A,Stronati M,Gerna G,Baldanti F

更新日期：2012-04-01 00:00:00

abstract：:There is an obvious concern globally regarding the fact about the emerging coronavirus 2019 novel coronavirus (2019-nCoV) as a worldwide public health threat. As the outbreak of COVID-19 causes by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) progresses within China and beyond, rapidly available epi...

journal_title：Journal of medical virology

authors： Dey SK,Rahman MM,Siddiqi UR,Howlader A

更新日期：2020-06-01 00:00:00

abstract：:Hepatitis C Virus (HCV) NS3 protease is an attractive target for antiviral agent development because it is required for viral replication. Because a stable cell culture system or small animal model to study HCV replication is not readily available, we constructed an in vitro model allowing the investigation of NS3 tra...

journal_title：Journal of medical virology

authors： Heintges T,Encke J,zu Putlitz J,Wands JR

更新日期：2001-12-01 00:00:00

abstract：:The effects of 6-diazo-5-oxo-L-norleucine (DON), 2-deoxy-D-glucose (DOG), and tunicamycin (TM) on the replication of poliovirus (PV) and vesicular stomatitis virus (VSV) were examined. During a 48-hr replication period, TM, DON, and DOG inhibit VSV plaque formation in HEp-2 cells by 99.9%, 99.8%, and 99.9% respectivel...

journal_title：Journal of medical virology

authors： Goldstein G,Guskey LE

更新日期：1984-01-01 00:00:00

abstract：:The human cytomegalovirus (HCMV), a member of the Herpesviridae, is the most frequent cause of congenital virus infections and a major cause of morbidity and mortality in immunocompromised patients. Due to the lack of an appropriate animal model, insight into the pathogenesis of HCMV infections originates primarily fr...

journal_title：Journal of medical virology

authors： Bissinger AL,Sinzger C,Kaiserling E,Jahn G

更新日期：2002-06-01 00:00:00

abstract：:Previously, it was reported that productive viral infection, viral protein synthesis, and viral RNA replication of respiratory syncytial virus (RSV) operated efficiently in two human epithelial cell lines (HEp-2 and A549), but not in a human mast-cell line, HMC-1. Based on these observations, it was hypothesized that ...

journal_title：Journal of medical virology

authors： Shirato K,Ujike M,Kawase M,Matsuyama S

更新日期：2012-02-01 00:00:00

abstract：:Antibodies to herpes simplex virus and Epstein-Barr virus were sought in the sera of 33 patients with endoscopically proved duodenal ulcer and 33 healthy controls. Neither the prevalence nor the antibody levels to both viruses were significantly different between the two groups. These results suggest that herpes virus...

journal_title：Journal of medical virology

authors： Kottaridis SD,Mihas TA,Goula I,Mihas AA

更新日期：1989-11-01 00:00:00

abstract：:We report a real-life 3D therapy failure in a patient treated with ombitasvir (OMV)/paritaprevir/ritonavir and dasabuvir without ribavirin (3D-R). He had therapy failure at week 12 after the end of treatment. We detected resistance-associated substitutions (RASs) plus polymorphisms on NS3, NS5A, and NS5B target region...

journal_title：Journal of medical virology

authors： Marascio N,Pavia G,Romeo I,Talarico C,Di Salvo S,Reale M,Marano V,Barreca GS,Fabiani F,Perrotti N,De Siena M,Giancotti F,Gravina T,Alcaro S,Artese A,Torti C,Liberto MC,Focà A

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

journal_title：Journal of medical virology

authors： Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

更新日期：2019-07-01 00:00:00

abstract：:The seroprevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were evaluated in a random sample of 803 children attending school in Ashanti-Akim North district in Ghana in order to gain a better understanding of transmission patterns of these viruses, particularly horizontal transmission of HBV. T...

journal_title：Journal of medical virology

authors： Martinson FE,Weigle KA,Mushahwar IK,Weber DJ,Royce R,Lemon SM

更新日期：1996-03-01 00:00:00

abstract：:Dual infection with hepatitis B and C viruses is often encountered in endemic areas of both viruses. However, understanding of the clinical and virological implications is limited. The aim of this study was to investigate the role of each virus in liver injury and the interaction between the two viruses in dual infect...

journal_title：Journal of medical virology

authors： Ohkawa K,Hayashi N,Yuki N,Masuzawa M,Kato M,Yamamoto K,Hosotsubo H,Deguchi M,Katayama K,Kasahara A

更新日期：1995-07-01 00:00:00

abstract：:Men who have sex with men (MSM) are an important risk group for human immunodeficiency virus (HIV) and at high-risk of herpesvirus infection. However, limited information on epidemiologic patterns of HHV8 and HSV2 among MSM is available in mainland China. A cross-sectional study of 486 participants was performed in Sh...

journal_title：Journal of medical virology

authors： Liu Z,Fang Q,Zuo J,Wang J,Chen Y,Minhas V,Wood C,He N,Zhang T

更新日期：2017-05-01 00:00:00

abstract：:With multiple virus epicenters, COVID-19 has been declared a pandemic by the World Health Organization. Consequently, many countries have implemented different policies to manage this crisis including curfew and lockdown. However, the efficacy of individual policies remains unclear with respect to COVID-19 case develo...

journal_title：Journal of medical virology

authors： Khosrawipour V,Lau H,Khosrawipour T,Kocbach P,Ichii H,Bania J,Mikolajczyk A

更新日期：2020-07-01 00:00:00

abstract：:Regulatory T cells (T(reg)) provide a balance to immune T cell activation thereby protecting the body from pathogen-induced immunopathology. Several persistent viruses induce T(reg) that subvert protective immune mechanisms and promote viral persistence. Epstein-Barr virus (EBV) generally infects children subclinicall...

journal_title：Journal of medical virology

authors： Wingate PJ,McAulay KA,Anthony IC,Crawford DH

更新日期：2009-05-01 00:00:00

abstract：:Investigation of varicella-zoster virus (VZV) is important epidemiologically, and determination of its prevalence rate in human trigeminal ganglia is important to provide surveillance data. To date, studies on VZV detection in trigeminal ganglia have used specimens obtained from a relatively limited number of cadavers...

journal_title：Journal of medical virology

authors： Inoue H,Motani-Saitoh H,Sakurada K,Ikegaya H,Yajima D,Hayakawa M,Sato Y,Otsuka K,Kobayashi K,Nagasawa S,Iwase H

更新日期：2010-02-01 00:00:00

abstract：:The incidence of perinatal transmission of hepatitis B virus (HBV) depends on the HBeAg/anti-HBe status of the mother. While children of HBeAg-positive mothers have a 90% probability of acquiring a chronic hepatitis B virus carrier state, babies of anti-HBe-positive mothers are more likely to develop fulminant hepatit...

journal_title：Journal of medical virology

authors： Bahn A,Hilbert K,Martiné U,Westedt J,von Weizsäcker F,Wirth S

更新日期：1995-12-01 00:00:00

abstract：:Thirty-two cerebrospinal fluid (CSF) samples from eighteen patients with confirmed herpes simplex encephalitis (HSE) were assayed by an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of viral antigens. The results are expressed as an antigen ratio distinguishing between herpes simplex virus (HSV) ...

journal_title：Journal of medical virology

authors： Bos CA,Olding-Stenkvist E,Wilterdink JB,Scheffer AJ

更新日期：1987-02-01 00:00:00

abstract：:Paired serum and saliva samples were tested by enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) for the presence of human immunodeficiency virus (HIV) antibodies. The study group included 36 individuals known to be HIV seropositive and 14 healthy, seronegative controls. HIV antibodies were detected in a...

journal_title：Journal of medical virology

authors： Holmström P,Syrjänen S,Laine P,Valle SL,Suni J

更新日期：1990-04-01 00:00:00

abstract：:Little is known on the association between clinical factors and coronavirus disease 2019 (COVID-19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, ...

journal_title：Journal of medical virology

authors： Yazdanpanah Y,French COVID cohort investigators and study group.

更新日期：2020-10-15 00:00:00

abstract：:Until recently, human cytomegalovirus (hCMV) infection and anti-CMV treatment in transplanted patients have been monitored essentially by pp65 antigenemia, which is time-consuming and requires experienced operators. For the last two years, pp65 antigenemia levels have tended to be lower than previously in our laborato...

journal_title：Journal of medical virology

authors： Schvoerer E,Henriot S,Zachary P,Freitag R,Fuchs A,Fritsch S,Risch S,Meyer N,Caillard S,Lioure B,Stoll-Keller F

更新日期：2005-05-01 00:00:00

abstract：:Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...

journal_title：Journal of medical virology

authors： Nacheva EP,Ward KN,Brazma D,Virgili A,Howard J,Leong HN,Clark DA

更新日期：2008-11-01 00:00:00