Abstract：
:Little is known on the association between clinical factors and coronavirus disease 2019 (COVID-19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, according to mortality up to Day 60 after admission. For the analysis of risk factors of survival, analyses assessing associations between mortality and demographic characteristics or comorbidities were performed using a Cox regression model. Between January 24 and March 15, 2020, 246 patients with reverse-transcriptase polymerase chain reactions virologically confirmed COVID-19 were enrolled. In multivariate analysis, mortality at Day 60 (n = 42 patients, 17.1% [95% confidence interval, 12.6-22.4]) was associated with older age (adjusted hazard ratio [aHR] for age ≥ 65 years: 5.22 [2.56-10.63, p < .001]), gender (aHR for male: 2.97 [1.47-5.99, p = .002]), chronic pulmonary disease (aHR: 4.84 [2.32-10.07, p < .001]), obesity (aHR: 3.32 [1.70-6.52, p < .001]), and diabetes (aHR: 1.98 [1.01-3.89, p = .048]). The median nasopharyngeal viral load at admission was 6.4 log10 copies/ml and was associated with mortality regardless of clinical risk factors. Viral load decreased with time elapsed since symptoms onset. Our study confirmed that mortality was associated with clinical characteristics at admission. The viral load at admission was significantly lower in patients admitted late after the onset of symptoms in both dead and alive patients. Our results could improve earlier identification of patients with increased risk of mortality and adapted management.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Yazdanpanah Y,French COVID cohort investigators and study group.doi
10.1002/jmv.26601subject
Has Abstractpub_date
2020-10-15 00:00:00eissn
0146-6615issn
1096-9071pub_type
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journal_title：Journal of medical virology
pub_type： 杂志文章
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更新日期：2006-01-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：2001-03-01 00:00:00
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更新日期：2017-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Journal of medical virology
pub_type： 杂志文章
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journal_title：Journal of medical virology
pub_type： 杂志文章
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doi：
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pub_type： 杂志文章
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pub_type： 杂志文章,随机对照试验
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