Hyperglycemia, hydroxychloroquine, and the COVID-19 pandemic.

Abstract:

:Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated angiotensin-converting enzyme receptor 2 (ACE2) in the lung epithelium, and the degree and control of the pulmonary immune response to the SARS-CoV-2 spike protein at approximately day 8 to 10 after symptom onset, which may be related to both. Binding of ACE2 by SARS-CoV-2 in COVID-19 also suggests that prolonged uncontrolled hyperglycemia, and not just a history of diabetes mellitus, may be important in the pathogenesis of the disease. It is tempting to consider that the same mechanism acts in COVID-19 as in SARS, where an overactive macrophage M1 inflammatory response, as neutralizing antibodies to the SARS-CoV-2 spike protein form at day 7 to 10, results in acute respiratory distress syndrome (ARDS) in susceptible patients. It also allows consideration of agents, such as hydroxychloroquine, which may interfere with this overly brisk macrophage inflammatory response and perhaps influence the course of the disease, in particular, those that blunt but do not completely abrogate the M1 to M2 balance in macrophage polarization, as well as viral load, which in SARS appears to be temporally related to the onset of ARDS.

journal_name

J Med Virol

authors

Brufsky A

doi

10.1002/jmv.25887

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

770-775

issue

7

eissn

0146-6615

issn

1096-9071

journal_volume

92

pub_type

杂志文章,评审
  • Prediction of the virological response to etravirine in clinical practice: Comparison of three genotype algorithms.

    abstract::The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21461

    authors: Cotte L,Trabaud MA,Tardy JC,Brochier C,Gilibert RP,Miailhes P,Trépo C,André P

    更新日期:2009-04-01 00:00:00

  • Monoclonal antibody recognizing pre-S(2) epitope of hepatitis B virus: characterization of pre-S(2) epitope and anti-pre-S(2) antibody.

    abstract::A hybrid cell line producing monoclonal antibodies recognizing an epitope encoded by the pre-(S)2 region of hepatitis B virus (HBV) genome was obtained by fusion of mouse myeloma cells with lymphocytes from mice immunized with HBV. The monoclonal antibody Mo-F124 secreted from the hybrid line reacted with the pre-S(2)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200204

    authors: Budkowska A,Riottot MM,Dubreuil P,Lazizi Y,Brechot C,Sobczak E,Petit MA,Pillot J

    更新日期:1986-10-01 00:00:00

  • Poliovirus serotype 2 and coxsackievirus A promote the natural recombination of poliovirus.

    abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25620

    authors: Qian Y,Pu X,Yu Y,Yu X,Kong L,Liu L,Wang H,Shen H

    更新日期:2020-03-01 00:00:00

  • Clinical Significance of Cellular Immunity Function and Inflammatory Factors Assays in Alveolar Lavage Fluid for Severe COVID-19 Pneumonia.

    abstract::In this study, we aimed to investigate the changes of lymphocyte subsets (CD3+ , CD4+ , CD8+ ) and inflammatory factors (interleukin-6 [IL-6], hypersensitive C-reactive protein [HS-CRP], and procalcitonin [PCT]) of alveolar lavage fluid in patients with severe corona virus-2019 (COVID-19) pneumonia and their clinical ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26827

    authors: Liao L,Yang GH

    更新日期:2021-01-28 00:00:00

  • UV-inactivated measles virus stimulates human and mice naive lymphocytes to proliferate in vitro.

    abstract::Ultra violet (UV) light-inactivated measles virus was used for the lymphocyte proliferation assay, where it caused consistently adult human peripheral blood monolymphocytes (PBML) proliferation which was not dependent on the measles virus complement fixation titre in the donor's sera. When the cord blood lymphocytes f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460209

    authors: Tu R

    更新日期:1995-06-01 00:00:00

  • Detection of human cytomegalovirus DNA in perilymph of patients with sensorineural hearing loss using real-time PCR.

    abstract::Although cytomegalovirus (CMV) has been detected in the inner ear fluid of patients who succumbed to the complications of symptomatic congenital CMV infection, it has not been detected in the inner ear fluid of living patients. In this study, real-time polymerase chain reaction (PCR) was used to measure CMV DNA in cli...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10263

    authors: Sugiura S,Yoshikawa T,Nishiyama Y,Morishita Y,Sato E,Hattori T,Nakashima T

    更新日期:2003-01-01 00:00:00

  • The estimation of prevalence and risk factors of hepatitis B virus infection among blood donors in Chengdu, China.

    abstract::The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24339

    authors: Zhong L,Xi G,Zhang L,Liu S,Wan L,Yu L,Zhou M,Zhang J,He Y

    更新日期:2016-02-01 00:00:00

  • Local production of mumps IgG and IgM antibodies in the cerebrospinal fluid of meningitis patients.

    abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890080406

    authors: Ukkonen P,Granström ML,Räsänen J,Salonen EM,Penttinen K

    更新日期:1981-01-01 00:00:00

  • Occurrence rate and genotype distribution of the JC virus (JCV) in a sample from the Polish population.

    abstract::The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21153

    authors: Kmieciak D,Debicki S,Trzeciak WH

    更新日期:2008-06-01 00:00:00

  • Seroprevalence against Norwalk-like human caliciviruses in beijing, China.

    abstract::Serum specimens from 1,109 individuals at different ages in Beijing, China, were collected between April 1996 and March 1997 and tested for IgG antibodies against human caliciviruses using enzyme immune assays (EIAs). Baculovirus-expressed recombinant Norwalk virus (rNV) and Mexican virus (rMxV) capsid proteins were u...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200001)60:1<97::aid-jmv16>

    authors: Jing Y,Qian Y,Huo Y,Wang LP,Jiang X

    更新日期:2000-01-01 00:00:00

  • Interleukin-28B polymorphisms and interferon gamma inducible protein-10 serum levels in seronegative occult hepatitis C virus infection.

    abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24322

    authors: Bartolomé J,Castillo I,Quiroga JA,Carreño V

    更新日期:2016-02-01 00:00:00

  • Correlation of high-risk human papillomavirus genotypes persistence and risk of residual or recurrent cervical disease after surgical treatment.

    abstract::The evidence on genotype-specific risk in women infected with human papillomavirus (HPV) with normal cytology and the importance of the distinction of high-risk (HR)-HPV genotypes in the management of low-grade lesions suggest that the distinction of HR-HPV genotypes has the potential to improve the follow-up of patie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21198

    authors: Venturoli S,Ambretti S,Cricca M,Leo E,Costa S,Musiani M,Zerbini M

    更新日期:2008-08-01 00:00:00

  • HIV-1 Thai B strain has spread out of former plasma donors into general population through sexual contact in Henan, China.

    abstract::Henan, China is characterized by the outbreak of HIV epidemic of Thai B strain in former plasma donors in 1990s. After the forbidden of paid blood donation, whether Thai B strain will spread out of former plasma donors into sexual transmitted population is unknown. To answer the question, phylogenetic analysis was use...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24383

    authors: Li L,Sun G,Zhong P,Han J,Li T,Jia D,Liu Y,Sun C,Wang Z,Li H,Wang X,Li J

    更新日期:2016-04-01 00:00:00

  • Prevalence of drug resistance mutations in HAART patients infected with HIV-1 CRF06_cpx in Estonia.

    abstract::HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC +...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24361

    authors: Avi R,Pauskar M,Karki T,Kallas E,Jõgeda EL,Margus T,Huik K,Lutsar I

    更新日期:2016-03-01 00:00:00

  • Human platelet antigens polymorphisms; association to the development of liver fibrosis in patients with chronic hepatitis C.

    abstract::Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25423

    authors: Ghasemi A,Zadsar M,Shaiegan M,Samiei S,Namvar A,Rasouli M,Moosanejad M

    更新日期:2020-01-01 00:00:00

  • Induction of apoptosis in HT-29 cells infected with SA-11 rotavirus.

    abstract::Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>

    authors: Superti F,Ammendolia MG,Tinari A,Bucci B,Giammarioli AM,Rainaldi G,Rivabene R,Donelli G

    更新日期:1996-12-01 00:00:00

  • Comparison of the efficacy of sofosbuvir plus ribavirin in Chinese patients with genotype 3a or 3b HCV infection.

    abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25454

    authors: Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

    更新日期:2019-07-01 00:00:00

  • Prevalence of human papillomaviruses in patients with head and neck squamous cell carcinoma in Lithuania and Belarus.

    abstract::Overall, head and neck sqamous cell carcinoma accounts for more than 550,000 cases annually worldwide. It is well known that human papillomavirus (HPV) is the main risk factor for cervical cancer development. As the incidence and the mortality of cervical cancer are closely related to the HPV prevalence, we hypothesiz...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23750

    authors: Gudleviciene Z,Didziapetriene J,Mackeviciene I,Cicenas S,Smolyakova R,Zhukavetc A

    更新日期:2014-03-01 00:00:00

  • Incident and long-term HIV-1 infection among pregnant women in Brazil: Transmitted drug resistance and mother-to-child transmission.

    abstract::Primary infection, seroconversion, and transmitted drug resistance (TDR) during pregnancy may influence the risk of mother-to-child-transmission (MTCT) of HIV-1 infection. This study estimated recent seroconversion, TDR rates, HIV-1 subtypes and pregnancy outcomes among 95 recently diagnosed, antiretroviral (ARV)-naïv...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24540

    authors: Lima YA,Cardoso LP,Reis MN,Stefani MM

    更新日期:2016-11-01 00:00:00

  • Prevalence of abnormal anal cytology in women infected with HIV.

    abstract::Anal cancer is a rare disease. Nevertheless, it may be a reason for concern among groups in which its incidence is increasing: those who engage in anoreceptive intercourse, promiscuous persons, and those with sexually transmitted infections (HPV and HIV). The aim of this study was to evaluate the prevalence of abnorma...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23346

    authors: Chaves EB,Folgierini H,Capp E,von Eye Corleta H

    更新日期:2012-09-01 00:00:00

  • Prevalence of antibodies to enteroviruses and varicella-zoster virus among residents and overseas volunteers at agricultural settlements in Israel.

    abstract::Within the framework of a comprehensive study of the correlation between enteric diseases and wastewater utilization in agricultural settlements (kibbutzim) the prevalence of several viral antibodies was examined among kibbutz residents and overseas volunteers. The latter were assumed to be a group highly susceptible ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200211

    authors: Margalith M,Fattal B,Shuval HI,Morag A

    更新日期:1986-10-01 00:00:00

  • Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers.

    abstract::Phleboviruses are a large and widespread group of viruses that are transmitted by arthropods. Toscana virus is one of the principal agents that causes meningitis in humans during the summer in Italy and, possibly, in other Mediterranean countries. Rift Valley Fever virus can cause serious illness in both animals and h...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10465

    authors: Sánchez-Seco MP,Echevarría JM,Hernández L,Estévez D,Navarro-Marí JM,Tenorio A

    更新日期:2003-09-01 00:00:00

  • Coinfection of individual leukocytes with human cytomegalovirus and human immunodeficiency virus is a rare event in vivo.

    abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199608)49:4<283::AID-JMV5>

    authors: Bertram S,Hufert FT,van Lunzen J,von Laer D

    更新日期:1996-08-01 00:00:00

  • Estimating the seroprevalence of chikungunya virus exposure in Shimoga district, Karnataka state: A hospital-based study during 2014-2018.

    abstract::Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes. The disease is characterized by fever, headache, rash, severe joint, and muscle pain. To evaluate the disease burden in the population and the effectiveness of public health measures, periodic seroprevalence surveys are esse...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25581

    authors: Shilpa C,Kavitha K,Sudheesh N,Sabeena S,Prasad V,Hindol M,Arunkumar G

    更新日期:2020-01-01 00:00:00

  • Comparison of viral load and duration of virus shedding in symptomatic and asymptomatic neonatal rotavirus infections.

    abstract::A single rotavirus strain causing asymptomatic infections as well as severe gastrointestinal disease has been described in the neonatal nurseries of the Christian Medical College, Vellore. In this study, quantitative real-time RT-PCR was used to determine the association of viral load with the presence of gastrointest...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21872

    authors: Ramani S,Sankaran P,Arumugam R,Sarkar R,Banerjee I,Mohanty I,Jana AK,Kuruvilla KA,Kang G

    更新日期:2010-10-01 00:00:00

  • Hepatitis C and arboviral antibodies in the island populations of Mauritius and Rodrigues.

    abstract::A serological survey for antibodies to hepatitis C virus (HCV), dengue viruses (DEN), West Nile virus (WN), and sindbis virus (SIN) was carried out in sera of selected groups of the population of the Islands of Mauritius (n = 449) and Rodrigues (n = 115), Indian Ocean. 8.3% of 564 sera were positive for anti-HCV. In M...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440411

    authors: Schwarz TF,Dobler G,Gilch S,Jäger G

    更新日期:1994-12-01 00:00:00

  • Identification and characterization of enteric adenoviruses in infants and children hospitalized for acute gastroenteritis.

    abstract::Enteric adenoviruses are important etiological agents associated with sporadic infections and outbreaks of acute gastroenteritis in infants and children. Fecal samples were collected from 439 hospitalized patients in the years 2005-2007 from Pune, Aurangabad, and Nagpur cities of western India to identify the most pre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21331

    authors: Verma H,Chitambar SD,Varanasi G

    更新日期:2009-01-01 00:00:00

  • Titration of hepatitis B virus infectivity in the sera of pre-acute and late acute phases of HBV infection: transmission experiments to chimeric mice with human liver repopulated hepatocytes.

    abstract::Studies of hepatitis B virus (HBV) infection in non-human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV infectivity in serial stages of acu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21320

    authors: Tabuchi A,Tanaka J,Katayama K,Mizui M,Matsukura H,Yugi H,Shimada T,Miyakawa Y,Yoshizawa H

    更新日期:2008-12-01 00:00:00

  • Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of Echovirus 11.

    abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890090202

    authors: Mertens T,Hager H,Eggers HJ

    更新日期:1982-01-01 00:00:00

  • Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucrose.

    abstract::Physicochemical and molecular characterization studies of hepatitis C virus (HCV), the major causative agent of parenterally transmitted non-A, non-B hepatitis (PT-NANBH), strongly suggest that it is a pesti-/flavivirus-like virus. Additional studies show that the buoyant density of plasma-derived HCV in sucrose is si...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890340315

    authors: Bradley D,McCaustland K,Krawczynski K,Spelbring J,Humphrey C,Cook EH

    更新日期:1991-07-01 00:00:00