Abstract:
:Coronavirus disease-2019 (COVID-19) infection and its severity can be explained by the concentration of glycosylated severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) viral particles in the lung epithelium, the concentration of glycosylated angiotensin-converting enzyme receptor 2 (ACE2) in the lung epithelium, and the degree and control of the pulmonary immune response to the SARS-CoV-2 spike protein at approximately day 8 to 10 after symptom onset, which may be related to both. Binding of ACE2 by SARS-CoV-2 in COVID-19 also suggests that prolonged uncontrolled hyperglycemia, and not just a history of diabetes mellitus, may be important in the pathogenesis of the disease. It is tempting to consider that the same mechanism acts in COVID-19 as in SARS, where an overactive macrophage M1 inflammatory response, as neutralizing antibodies to the SARS-CoV-2 spike protein form at day 7 to 10, results in acute respiratory distress syndrome (ARDS) in susceptible patients. It also allows consideration of agents, such as hydroxychloroquine, which may interfere with this overly brisk macrophage inflammatory response and perhaps influence the course of the disease, in particular, those that blunt but do not completely abrogate the M1 to M2 balance in macrophage polarization, as well as viral load, which in SARS appears to be temporally related to the onset of ARDS.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Brufsky Adoi
10.1002/jmv.25887subject
Has Abstractpub_date
2020-07-01 00:00:00pages
770-775issue
7eissn
0146-6615issn
1096-9071journal_volume
92pub_type
杂志文章,评审abstract::The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21461
更新日期:2009-04-01 00:00:00
abstract::A hybrid cell line producing monoclonal antibodies recognizing an epitope encoded by the pre-(S)2 region of hepatitis B virus (HBV) genome was obtained by fusion of mouse myeloma cells with lymphocytes from mice immunized with HBV. The monoclonal antibody Mo-F124 secreted from the hybrid line reacted with the pre-S(2)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200204
更新日期:1986-10-01 00:00:00
abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25620
更新日期:2020-03-01 00:00:00
abstract::In this study, we aimed to investigate the changes of lymphocyte subsets (CD3+ , CD4+ , CD8+ ) and inflammatory factors (interleukin-6 [IL-6], hypersensitive C-reactive protein [HS-CRP], and procalcitonin [PCT]) of alveolar lavage fluid in patients with severe corona virus-2019 (COVID-19) pneumonia and their clinical ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26827
更新日期:2021-01-28 00:00:00
abstract::Ultra violet (UV) light-inactivated measles virus was used for the lymphocyte proliferation assay, where it caused consistently adult human peripheral blood monolymphocytes (PBML) proliferation which was not dependent on the measles virus complement fixation titre in the donor's sera. When the cord blood lymphocytes f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460209
更新日期:1995-06-01 00:00:00
abstract::Although cytomegalovirus (CMV) has been detected in the inner ear fluid of patients who succumbed to the complications of symptomatic congenital CMV infection, it has not been detected in the inner ear fluid of living patients. In this study, real-time polymerase chain reaction (PCR) was used to measure CMV DNA in cli...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10263
更新日期:2003-01-01 00:00:00
abstract::The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24339
更新日期:2016-02-01 00:00:00
abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890080406
更新日期:1981-01-01 00:00:00
abstract::The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21153
更新日期:2008-06-01 00:00:00
abstract::Serum specimens from 1,109 individuals at different ages in Beijing, China, were collected between April 1996 and March 1997 and tested for IgG antibodies against human caliciviruses using enzyme immune assays (EIAs). Baculovirus-expressed recombinant Norwalk virus (rNV) and Mexican virus (rMxV) capsid proteins were u...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200001)60:1<97::aid-jmv16>
更新日期:2000-01-01 00:00:00
abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24322
更新日期:2016-02-01 00:00:00
abstract::The evidence on genotype-specific risk in women infected with human papillomavirus (HPV) with normal cytology and the importance of the distinction of high-risk (HR)-HPV genotypes in the management of low-grade lesions suggest that the distinction of HR-HPV genotypes has the potential to improve the follow-up of patie...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21198
更新日期:2008-08-01 00:00:00
abstract::Henan, China is characterized by the outbreak of HIV epidemic of Thai B strain in former plasma donors in 1990s. After the forbidden of paid blood donation, whether Thai B strain will spread out of former plasma donors into sexual transmitted population is unknown. To answer the question, phylogenetic analysis was use...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24383
更新日期:2016-04-01 00:00:00
abstract::HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC +...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24361
更新日期:2016-03-01 00:00:00
abstract::Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25423
更新日期:2020-01-01 00:00:00
abstract::Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25454
更新日期:2019-07-01 00:00:00
abstract::Overall, head and neck sqamous cell carcinoma accounts for more than 550,000 cases annually worldwide. It is well known that human papillomavirus (HPV) is the main risk factor for cervical cancer development. As the incidence and the mortality of cervical cancer are closely related to the HPV prevalence, we hypothesiz...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23750
更新日期:2014-03-01 00:00:00
abstract::Primary infection, seroconversion, and transmitted drug resistance (TDR) during pregnancy may influence the risk of mother-to-child-transmission (MTCT) of HIV-1 infection. This study estimated recent seroconversion, TDR rates, HIV-1 subtypes and pregnancy outcomes among 95 recently diagnosed, antiretroviral (ARV)-naïv...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24540
更新日期:2016-11-01 00:00:00
abstract::Anal cancer is a rare disease. Nevertheless, it may be a reason for concern among groups in which its incidence is increasing: those who engage in anoreceptive intercourse, promiscuous persons, and those with sexually transmitted infections (HPV and HIV). The aim of this study was to evaluate the prevalence of abnorma...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23346
更新日期:2012-09-01 00:00:00
abstract::Within the framework of a comprehensive study of the correlation between enteric diseases and wastewater utilization in agricultural settlements (kibbutzim) the prevalence of several viral antibodies was examined among kibbutz residents and overseas volunteers. The latter were assumed to be a group highly susceptible ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200211
更新日期:1986-10-01 00:00:00
abstract::Phleboviruses are a large and widespread group of viruses that are transmitted by arthropods. Toscana virus is one of the principal agents that causes meningitis in humans during the summer in Italy and, possibly, in other Mediterranean countries. Rift Valley Fever virus can cause serious illness in both animals and h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10465
更新日期:2003-09-01 00:00:00
abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199608)49:4<283::AID-JMV5>
更新日期:1996-08-01 00:00:00
abstract::Chikungunya fever is a viral disease transmitted to humans by the bite of infected mosquitoes. The disease is characterized by fever, headache, rash, severe joint, and muscle pain. To evaluate the disease burden in the population and the effectiveness of public health measures, periodic seroprevalence surveys are esse...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25581
更新日期:2020-01-01 00:00:00
abstract::A single rotavirus strain causing asymptomatic infections as well as severe gastrointestinal disease has been described in the neonatal nurseries of the Christian Medical College, Vellore. In this study, quantitative real-time RT-PCR was used to determine the association of viral load with the presence of gastrointest...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21872
更新日期:2010-10-01 00:00:00
abstract::A serological survey for antibodies to hepatitis C virus (HCV), dengue viruses (DEN), West Nile virus (WN), and sindbis virus (SIN) was carried out in sera of selected groups of the population of the Islands of Mauritius (n = 449) and Rodrigues (n = 115), Indian Ocean. 8.3% of 564 sera were positive for anti-HCV. In M...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440411
更新日期:1994-12-01 00:00:00
abstract::Enteric adenoviruses are important etiological agents associated with sporadic infections and outbreaks of acute gastroenteritis in infants and children. Fecal samples were collected from 439 hospitalized patients in the years 2005-2007 from Pune, Aurangabad, and Nagpur cities of western India to identify the most pre...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21331
更新日期:2009-01-01 00:00:00
abstract::Studies of hepatitis B virus (HBV) infection in non-human primates such as chimpanzees are no longer possible due to ethical considerations and the endangered status of chimpanzees since April 2007 in Japan. A human hepatocyte transplanted chimeric mouse was used to characterize HBV infectivity in serial stages of acu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21320
更新日期:2008-12-01 00:00:00
abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890090202
更新日期:1982-01-01 00:00:00
abstract::Physicochemical and molecular characterization studies of hepatitis C virus (HCV), the major causative agent of parenterally transmitted non-A, non-B hepatitis (PT-NANBH), strongly suggest that it is a pesti-/flavivirus-like virus. Additional studies show that the buoyant density of plasma-derived HCV in sucrose is si...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890340315
更新日期:1991-07-01 00:00:00