Human parechovirus infections in patients admitted to hospital in Northern Italy, 2008-2010.

Abstract:

:Human parechoviruses (HPeVs) infection is associated with a wide range of clinical syndromes such as respiratory, gastrointestinal, neurologic diseases, and neonatal sepsis-like illness. The main objective of this study was to investigate the epidemiology of HPeVs infection in hospitalized patients in a period of 2 years. Respiratory samples from 3,525 patients with respiratory syndrome, cerebrospinal fluid (CSF) from 340 patients with neurologic syndrome as well as CSF and plasma samples from five neonatal patients with sepsis-like illness collected from October 2008 to 2010 were tested retrospectively using HPeV-specific real-time RT-PCR. Phylogenetic analysis of VP3/VP1 region was performed on the positive samples. Fourteen out of 3,525 (0.4%) patients with respiratory syndrome and five out of five patients with sepsis-like illness were positive for HPeV. In 3/5 patients with sepsis-like illness multiple samples (e.g., stool, plasma, CSF, or respiratory samples) were available, and HPeV was found in all specimens. In contrast, no positive CSF was detected among the 340 patients with neurologic syndromes. Eleven patients (57.9%) were infected with HPeV1 strain, 7 (36.8%) with HPeV3, and 1 (5.3%) with HPeV6 strains. Ten of the 14 HPeV patients with respiratory syndrome were co-infected with other respiratory viruses (eight with rhinovirus and two with coronavirus OC43). All five patients with sepsis-like illness were less than 1 month of age and were infected with HPeV3. Although not circulating at high frequency and unlikely to cause respiratory syndrome, HPeV was associated with severe clinical syndromes in a minority of newborns.

journal_name

J Med Virol

authors

Piralla A,Furione M,Rovida F,Marchi A,Stronati M,Gerna G,Baldanti F

doi

10.1002/jmv.23197

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

686-90

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

84

pub_type

杂志文章
  • Clinical and economic burden of pre-emptive therapy of cytomegalovirus infection in hospitalized allogeneic hematopoietic cell transplant recipients.

    abstract::Cytomegalovirus (CMV) infection remains a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a retrospective study to determine the clinical and economic burden of pre-emptive therapy (PET) for CMV infection in 100 consecutive hospitalized adult CMV positive serostatus allo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25574

    authors: El Haddad L,Ghantoji SS,Park AK,Batista MV,Schelfhout J,Hachem J,Lobo Y,Jiang Y,Rondon G,Champlin R,Chemaly RF

    更新日期:2020-01-01 00:00:00

  • Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.

    abstract::Virus variants escaping from host immunity may be implicated in the pathogenesis of hepatitis B virus (HBV) infection. In this cross-sectional study, the association was evaluated of the frequency of amino acid variation within the immunogenic epitopes of surface gene with different disease stages of chronic HBV infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10169

    authors: Liu CJ,Kao JH,Shau WY,Chen PJ,Lai MY,Chen DS

    更新日期:2002-09-01 00:00:00

  • Comparison of the hypervariable region of hepatitis C virus genomes in plasma and liver.

    abstract::Nucleotide sequences of the hypervariable region of hepatitis C virus genomes obtained from plasma change rapidly during the course of infection and are believed to play a part in immunological escape and consequently in the development of persistent infection. It is not known, however, whether these changes also occu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460103

    authors: Sakamoto N,Enomoto N,Kurosaki M,Asahina Y,Maekawa S,Koizumi K,Sakuma I,Murakami T,Marumo F,Sato C

    更新日期:1995-05-01 00:00:00

  • Human T-cell lymphotropic virus antibody prevalence in HIV-1-infected individuals attending a sexual health clinic in South-East London.

    abstract::Human immunodeficiency virus (HIV) and human T-cell lymphotropic virus (HTLV) are both retroviruses with similar routes of transmission. A number of reports suggest variable clinical outcomes in HIV and HTLV co-infected individuals. There is no published information regarding the prevalence of HIV and HTLV co-infectio...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20336

    authors: Cooke FJ,Geretti AM,Zuckerman M

    更新日期:2005-06-01 00:00:00

  • Human herpesvirus-6 modulates RANTES production in primary human endothelial cell cultures.

    abstract::Human herpesvirus 6 (HHV6) is a beta-herpesvirus capable of infecting several cell types from different origins. HHV6 is the etiological agent of exantem subitum and has been associated with several diseases, all characterized by an inflammatory response triggered by chemokines. We show that strain U1102 of HHV6 is ab...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10416

    authors: Caruso A,Favilli F,Rotola A,Comar M,Horejsh D,Alessandri G,Grassi M,Di Luca D,Fiorentini S

    更新日期:2003-07-01 00:00:00

  • HBV DNA integration and HBV-transcript expression in non-B, non-C hepatocellular carcinoma in Japan.

    abstract::Few studies have examined the etiology of hepatocellular carcinoma (HCC) in patients without hepatitis virus infection. We evaluated the role of occult hepatitis B virus (HBV) infection in the development of HCC in Japanese patients without hepatitis B surface antigen (HBsAg) and antibodies to hepatitis C antigen (ant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10514

    authors: Tamori A,Nishiguchi S,Kubo S,Narimatsu T,Habu D,Takeda T,Hirohashi K,Shiomi S

    更新日期:2003-12-01 00:00:00

  • Longitudinal study of plasma HIV-1 RNA concentrations during the asymptomatic stage of HIV infection measured using AMPLICOR HIV monitor and NASBA HIV-1 RNA QT tests. ACCTES Association.

    abstract::The predictive value of two methods for measuring HIV RNA concentration in plasma was assessed in relation to CD4 lymphocyte counts during the asymptomatic period of infection. The design was a retrospective longitudinal case-control study for a mean period of 60 months involving 20 asymptomatic patients included in t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Delamare C,Burgard M,Deveau C,Chaix ML,Ivanoff S,Ramirez D,Tachet A,Bary M,Rouzioux C

    更新日期:1998-01-01 00:00:00

  • A hepatitis B virus variant found in the sera of immunised children induces a conformational change in the HBsAg "a" determinant.

    abstract::The emergence of variants in the outer envelope proteins of hepatitis B virus (HBV) are found among individuals vaccinated against HBV and asymptomatic carriers of the infection. For example, children in The Gambia vaccinated against hepatitis B may show serological evidence of breakthrough infections, particularly if...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199908)58:4<346::aid-jmv5>

    authors: Karthigesu VD,Allison LM,Ferguson M,Howard CR

    更新日期:1999-08-01 00:00:00

  • Persistent hyperendemicity of hepatitis C virus infection in Taiwan: the important role of iatrogenic risk factors.

    abstract::The purpose of this study was to investigate determinants of endemic hepatitis C virus (HCV) infection within communities in Taiwan. A two-phase study, including a seroprevalence survey and a prevalent case-control study at the first phase, which has been published previously, and a follow-up seroconversion determinat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sun CA,Chen HC,Lu SN,Chen CJ,Lu CF,You SL,Lin SH

    更新日期:2001-09-01 00:00:00

  • Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China.

    abstract::Co-infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) has been shown to be associated with a more severe form of acute and chronic hepatitis. Cloning and expression of recombinant HDV antigen (rHDAg) in Escherichiacoli are described. Using purified rHDAg, a cost-effective indirect anti-HDV enzyme-l...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23212

    authors: Shen L,Gu Y,Sun L,Yang Y,Wang F,Li Y,Bi S

    更新日期:2012-03-01 00:00:00

  • Effects of drug resistance on viral load in patients failing antiretroviral therapy.

    abstract::Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect. In this study, w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20582

    authors: Machouf N,Thomas R,Nguyen VK,Trottier B,Boulassel MR,Wainberg MA,Routy JP

    更新日期:2006-05-01 00:00:00

  • Standardization of a plaque assay for Lassa virus.

    abstract::The plaque reduction neutralization test (PRNT) has been used routinely in serological studies with such arenaviruses as Junin, Machupo, and Parana. However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test wi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890220110

    authors: Tomori O,Johnson KM,Kiley MP,Elliott LH

    更新日期:1987-05-01 00:00:00

  • Association of mortality and recent Mycoplasma pneumoniae infection in COVID-19 patients.

    abstract::To compare characteristics and outcomes of patients who had COVID-19 with Mycoplasma pneumoniae immunoglobulin M (IgM) antibodies to those without M. pneumoniae antibodies. We retrospectively reviewed cases admitted over a 4-week period between 17 March 2020 and 14 April 2020 to the Hoboken University Medical Center, ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26467

    authors: Amin D,McKitish K,Shah PS

    更新日期:2021-02-01 00:00:00

  • A-549 is a suitable cell line for primary isolation of coxsackie B viruses.

    abstract::A common receptor for coxsackie B virus and adenovirus has been described recently in cells of human and murine origin. Since the established cell line A-549 is suitable for adenoviruses, the potential use of A-549 cells for the isolation of coxsackie B viruses from clinical samples was investigated. All throat swabs ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Otero JR,Folgueira L,Trallero G,Prieto C,Maldonado S,Babiano MJ,Martinez-Alonso I

    更新日期:2001-11-01 00:00:00

  • Improved prenatal diagnosis of congenital human cytomegalovirus infection by a modified nested polymerase chain reaction.

    abstract::Two major variables may cause false-negative results in prenatal diagnosis of congenital human cytomegalovirus (HCMV) infection: sensitivity of the techniques(s) used; and time elapsed between maternal infection and antenatal testing. Previous results indicated that rapid HCMV isolation from amniotic fluid samples and...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199809)56:1<99::aid-jmv16>

    authors: Revello MG,Sarasini A,Zavattoni M,Baldanti F,Gerna G

    更新日期:1998-09-01 00:00:00

  • Discharged COVID-19 patients testing positive again for SARS-CoV-2 RNA: A minireview of published studies from China.

    abstract::In the ongoing coronavirus disease 2019 (COVID-19) pandemic, one potential cause of concern is that some discharged COVID-19 patients are testing positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. To better understand what is happening and to provide public health policy planners and ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26250

    authors: Han Z,Battaglia F,Terlecky SR

    更新日期:2020-07-01 00:00:00

  • Comparison of the conventional multiplex RT-PCR, real time RT-PCR and Luminex xTAG® RVP fast assay for the detection of respiratory viruses.

    abstract::Detection of respiratory viruses using polymerase chain reaction (PCR) is sensitive, specific and cost effective, having huge potential for patient management. In this study, the performance of an in-house developed conventional multiplex RT-PCR (mRT-PCR), real time RT-PCR (rtRT-PCR) and Luminex xTAG(®) RVP fast assay...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24299

    authors: Choudhary ML,Anand SP,Tikhe SA,Walimbe AM,Potdar VA,Chadha MS,Mishra AC

    更新日期:2016-01-01 00:00:00

  • Detection of human cytomegalovirus early and late antigen and DNA production in cell culture and the effects of dimethyl sulfoxide, dexamethasone, and DNA inhibitors on early antigen induction.

    abstract::Recently a conventional method for the laboratory diagnosis of human cytomegalovirus (HCMV) infection was improved by using centrifugation culture to enhance viral adsorption and by detecting HCMV early antigen and DNA. Comparison of the sensitivity of three rapid methods using commercial diagnostic reagents for the d...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890300204

    authors: Li SB,Fong CK

    更新日期:1990-02-01 00:00:00

  • Kinetics of HBV DNA and HBsAg in acute hepatitis B patients with and without coinfection by other hepatitis viruses.

    abstract::The kinetics of hepatitis B virus (HBV) and its surface antigen (HBsAg) during acute hepatitis has not yet been studied accurately in a representative number of patients. The influence of coinfecting hepatitis viruses during the acute phase of infection is not known. Three to four serum samples from 21 patients with a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10291

    authors: Chulanov VP,Shipulin GA,Schaefer S,Gerlich WH

    更新日期:2003-03-01 00:00:00

  • New amino acid changes in drug resistance sites and HBsAg in hepatitis B virus genotype H.

    abstract::Long-term treatment with retrotranscriptase (RT) inhibitors eventually leads to the development of drug resistance. Drug-related mutations occur naturally and these can be found in hepatitis B virus (HBV) carriers who have never received antiviral therapy. HBsAg are overlapped with RT domain, thus nucleot(s)ide analog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24098

    authors: Fernández-Galindo DA,Sánchez-Ávila F,Bobadilla-Morales L,Gómez-Quiróz P,Bueno-Topete M,Armendáriz-Borunda J,Sánchez-Orozco LV

    更新日期:2015-06-01 00:00:00

  • Identification of archetype and rearranged forms of BK virus in leukocytes from healthy individuals.

    abstract::BK virus (BKV) establishes a persistent, asymptomatic infection in more than 80% of the human population, and in immunocompromised individuals BKV causes acute urinary tract infections. Two forms of BKV, archetype and rearranged, have been recovered previously from urine samples. The rearranged form is believed to hav...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Chatterjee M,Weyandt TB,Frisque RJ

    更新日期:2000-03-01 00:00:00

  • A natural inter-genotypic (2b/1b) recombinant of hepatitis C virus in the Philippines.

    abstract::The prevalence study and the characterization of hepatitis C virus (HCV) was carried out in the Philippines and the sequence determination of the 5'-untranslated region (5'-UTR)-Core and the NS5B regions of HCV was carried out in this study. An HCV strain (SE-03-07-1689) collected in Metro Manila, Philippines, belonge...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20714

    authors: Kageyama S,Agdamag DM,Alesna ET,Leaño PS,Heredia AM,Abellanosa-Tac-An IP,Jereza LD,Tanimoto T,Yamamura J,Ichimura H

    更新日期:2006-11-01 00:00:00

  • Immunoreactivity of human and rabbit antisera to hepatitis A virus.

    abstract::Rabbit antibodies produced by immunization with complete hepatitis A virions (HAV) recognized all the viral structural proteins and neutralized HAV infectivity in cell culture. Rabbit antibodies to chromatographically purified individual viral proteins and to synthetic peptides representing epitopes on the structural ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890240212

    authors: Gauss-Müller V,Deinhardt F

    更新日期:1988-02-01 00:00:00

  • Inhibition of hepatitis C virus NS3 function by antisense oligodeoxynucleotides and protease inhibitor.

    abstract::Hepatitis C Virus (HCV) NS3 protease is an attractive target for antiviral agent development because it is required for viral replication. Because a stable cell culture system or small animal model to study HCV replication is not readily available, we constructed an in vitro model allowing the investigation of NS3 tra...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2089

    authors: Heintges T,Encke J,zu Putlitz J,Wands JR

    更新日期:2001-12-01 00:00:00

  • Will the emergent SARS-CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID19?

    abstract::As the coronavirus disease 2019 pandemic keep tackling global public health systems worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) genome keeps mutating. In that regard, the recent emergence of the B.1.1.7 lineage in the UK has called the attention of global authorities. One point of concer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26823

    authors: Ramírez JD,Muñoz M,Patiño LH,Ballesteros N,Paniz-Mondolfi A

    更新日期:2021-01-28 00:00:00

  • Fitness of Japanese encephalitis virus to Neuro-2a cells is determined by interactions of the viral envelope protein with highly sulfated glycosaminoglycans on the cell surface.

    abstract::Genetically different subpopulations were identified and purified from Japanese Encephalitis virus (JEV). Those with small plaques (SPs; <2 mm in diameter), derived from strains of T1P1, CJN, and CC27, were more competent than those with large plaques (LPs; >5 mm in diameter) when passaged in Neuro-2a cells. Differenc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20406

    authors: Chiou SS,Liu H,Chuang CK,Lin CC,Chen WJ

    更新日期:2005-08-01 00:00:00

  • Higher risk of hepatitis C virus perinatal transmission from drug user mothers is mediated by peripheral blood mononuclear cell infection.

    abstract::Maternal injection drug use and peripheral blood mononuclear cell infection by hepatitis C virus are important risk factors for perinatal transmission of the virus. The aim of present study was to evaluate the independent association of these two factors on perinatal transmission. Forty-eight consecutive mothers who t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21023

    authors: Azzari C,Moriondo M,Indolfi G,Betti L,Gambineri E,de Martino M,Resti M

    更新日期:2008-01-01 00:00:00

  • Antiviral effects of antisense RNA on hepatitis C virus RNA translation and expression.

    abstract::We developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression. An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequences and used to gene...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Wakita T,Moradpour D,Tokushihge K,Wands JR

    更新日期:1999-03-01 00:00:00

  • Presence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplification.

    abstract::Hepatitis C virus (HCV) represents a major cause of posttransfusion hepatitis worldwide. Posttransfusion hepatitis associated with hepatitis B virus (HBV) continues to occur. HBsAg-negative donor sera from the Rhode Island Blood Center between 1987 and 1988 were screened using more sensitive techniques to assess the p...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420210

    authors: Liang TJ,Bodenheimer HC Jr,Yankee R,Brown NV,Chang K,Huang J,Wands JR

    更新日期:1994-02-01 00:00:00

  • Decompensated cirrhosis and liver transplantation negatively impact in DAA treatment response: Real-world experience from HCV-LALREAN cohort.

    abstract:INTRODUCTION:Although the effectiveness of direct-acting antivirals (DAAs) for the treatment of chronic hepatitis C virus (HCV) has been reported in real-world settings, predictive factors of treatment failure are lacking. Therefore, we sought to explore the baseline predictors of treatment response to DAAs. METHODS:T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26383

    authors: Ridruejo E,Piñero F,Mendizabal M,Cheinquer H,Wolff FH,Anders M,Reggiardo V,Ameigeiras B,Palazzo A,Alonso C,Schinoni MI,Zuain MGV,Tanno F,Figueroa S,Santos L,Peralta M,Soza A,Vistarini C,Adrover R,Fernández N,Perez

    更新日期:2020-08-04 00:00:00