Regulatory T cell activity in primary and persistent Epstein-Barr virus infection.

Abstract:

:Regulatory T cells (T(reg)) provide a balance to immune T cell activation thereby protecting the body from pathogen-induced immunopathology. Several persistent viruses induce T(reg) that subvert protective immune mechanisms and promote viral persistence. Epstein-Barr virus (EBV) generally infects children subclinically and persists thereafter, but primary infection in early adulthood may cause immunopathological damage manifest as infectious mononucleosis. In this study the role of T(reg) was investigated in acute infectious mononucleosis and healthy EBV seropositive donors. The proportion of CD4(+)CD25(high) T cells in blood from infectious mononucleosis patients was significantly lower than in seropositive donors (P = 0.05). Using the FOXP3 marker for T(reg) the same frequency and extra-follicular distribution of T(reg) was noted in infectious mononucleosis and control tonsils. Regulatory cytokines, interleukin (IL)-10 and transforming growth factor (TGF)-beta, were significantly raised in infectious mononucleosis compared to seropositive donor plasma (P = 0.0001, P = 0.0004 respectively) although levels of IL-10 peaked earlier in infectious mononucleosis than TGF-beta. Previous studies identified EBV latent membrane protein (LMP)-1-induced T(reg) activity [Marshall et al. (2003): J Immunol 170:6183-6189; Marshall et al. (2007): Brit J Haematol 139:81-89], and in this study a significant reduction in interferon-gamma production was found from infectious mononucleosis but not seropositive donor lymphocytes after stimulation with a recall antigen when LMP-1 peptide PRG was added (P = 0.03). It is possible that T(reg) are important in controlling primary EBV infection to a subclinical level in most cases and that infectious mononucleosis represents a failure of this protective mechanism.

journal_name

J Med Virol

authors

Wingate PJ,McAulay KA,Anthony IC,Crawford DH

doi

10.1002/jmv.21445

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

870-7

issue

5

eissn

0146-6615

issn

1096-9071

journal_volume

81

pub_type

杂志文章
  • Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010.

    abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23436

    authors: Than VT,Kang H,Lim I,Kim W

    更新日期:2013-01-01 00:00:00

  • Virus-like particles in the liver of a patient with fulminant hepatitis and antibody to hepatitis E virus.

    abstract::In earlier studies, hepatitis E virus (HEV) particles were detected in the stools of patients with enterically transmitted non-A, non-B (ENANB) hepatitis, and HEV was etiologically associated with this disease. Such particles have not been observed in the liver, however. We describe the pathological findings in the li...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310310

    authors: Asher LV,Innis BL,Shrestha MP,Ticehurst J,Baze WB

    更新日期:1990-07-01 00:00:00

  • Genome types of adenovirus type 7 isolated in Hiroshima City.

    abstract::One hundred thirty-two strains of adenovirus type 7 were isolated in Hiroshima City during the period 1995-1999. About 80% of the viruses were isolated from patients with respiratory illness, and about 70% were isolated from children younger than 6 years old. DNA restriction analysis was performed on 58 of the 132 iso...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10287

    authors: Ikeda Y,Yamaoka K,Noda M,Ogino T

    更新日期:2003-02-01 00:00:00

  • Impact of disease-modifying drugs on the severity of  COVID-19 infection in multiple sclerosis patients.

    abstract::Recent evidence suggested that neurological manifestations occur in patients with a severe form of coronavirus disease (COVID-19). On the basis of this issue, neurologists are very concerned about patients with neurological disorders, especially multiple sclerosis (MS), as consumers of immunosuppressive or immune-modu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26593

    authors: Rostami Mansoor S,Ghasemi-Kasman M

    更新日期:2020-10-12 00:00:00

  • Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe.

    abstract::Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25390

    authors: Ling J,Verner-Carlsson J,Eriksson P,Plyusnina A,Löhmus M,Järhult JD,van de Goot F,Plyusnin A,Lundkvist Å,Sironen T

    更新日期:2019-05-01 00:00:00

  • Longitudinal use of phenotypic resistance testing to HIV-1 protease inhibitors in patients developing HAART failure.

    abstract::An "in-house" recombinant virus protease inhibitor susceptibility assay was carried out (median of 3 per patient) retrospectively in 26 patients failing HIV protease inhibitor based therapy at regular intervals to the initiation of the first protease inhibitor. Patients were treated with either indinavir (N = 6), rito...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10076

    authors: Servais J,Plesséria JM,Lambert C,Fontaine E,Robert I,Arendt V,Staub T,Schneider F,Hemmer R,Schmit JC

    更新日期:2002-07-01 00:00:00

  • Simple haemadherence test for the detection of class-specific immunoglobulins to hepatitis A virus.

    abstract::The ability of hepatitis A virus (HAV) to agglutinate human erythrocytes was used to develop IgM and IgG antibody capture haemadherence tests (MACHAT and GACHAT). Haemadherence was dependent on the pH of the red cell suspension and was best in the pH range 5.4 to 5.8. The tests were applied to serum, urine, and saliva...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890390106

    authors: Perry KR,Parry JV

    更新日期:1993-01-01 00:00:00

  • Potential of large "first generation" human-to-human transmission of 2019-nCoV.

    abstract::To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok...

    journal_title:Journal of medical virology

    pub_type: 评论,杂志文章

    doi:10.1002/jmv.25693

    authors: Li X,Zai J,Wang X,Li Y

    更新日期:2020-04-01 00:00:00

  • Prevalence of HBV genotypes in Central and Eastern Europe.

    abstract::The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotyp...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.21294

    authors: Deterding K,Constantinescu I,Nedelcu FD,Gervain J,Nemecek V,Srtunecky O,Vince A,Grgurevic I,Bielawski KP,Zalewska M,Bock T,Ambrozaitis A,Stanczak J,Takács M,Chulanov V,Slusarczyk J,Drazd'áková M,Wiegand J,Cornberg M,

    更新日期:2008-10-01 00:00:00

  • Development and application of a one-step real-time RT-PCR using a minor-groove-binding probe for the detection of a novel bunyavirus in clinical specimens.

    abstract::A highly sensitive one-step real-time RT-PCR method using a minor-groove-binding (MGB) probe was developed for detection and quantitation of severe febrile with thrombocytopenia syndrome virus (SFTSV). The assay could discriminate SFTSV infection from other related viral diseases in human with a minimum detection limi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23415

    authors: Li Z,Cui L,Zhou M,Qi X,Bao C,Hu J,Shan J,Wu B,Wang S,Guo X,Jiao Y,Tang F,Wang H

    更新日期:2013-02-01 00:00:00

  • Sequence variation within the human immunodeficiency virus V3 loop at seroconversion.

    abstract::Analysis of the HIV-1 V3 quasispecies present in an individual at the time of seroconversion was carried out. The polymerase chain reaction (PCR) was used to amplify proviral HIV-1 DNA extracted from peripheral blood mononuclear cells from a patient who was viraemic (p24 = 15 pg/ml) and had an equivocal HIV-1 antibody...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890410403

    authors: Ait-Khaled M,Emery VC

    更新日期:1993-12-01 00:00:00

  • Different HIV-1 env frames: gp120 and ASP (antisense protein) biosynthesis, and theirs co-variation tropic amino acid signatures in X4- and R5-viruses.

    abstract::Antisense protein (ASP) is the new actor of viral life of Human Immunodeficiency Virus type 1 (HIV-1) although proposed above 20 years ago. The asp ORF is into complementary strand of the gp120/gp41 junction of env gene. The ASP biological role remains little known. Knowing the Env markers of viral tropism, a dataset ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24611

    authors: Dimonte S

    更新日期:2017-01-01 00:00:00

  • Natural histories of hepatitis C virus infection in men and women simulated by the Markov model.

    abstract::The Markov model was introduced to simulate natural histories of hepatitis C virus (HCV) infection in men and women. The data set was constructed on 942 HCV carriers who were examined at least once a year without receiving antiviral therapies. Based on 2,251 patient-year data, the probabilities of transition between a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10406

    authors: Tanaka J,Kumada H,Ikeda K,Chayama K,Mizui M,Hino K,Katayama K,Kumagai J,Komiya Y,Miyakawa Y,Yoshizawa H

    更新日期:2003-07-01 00:00:00

  • Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention.

    abstract::Hepatitis E virus (HEV), the sole member of the genus Hepevirus in the family of Hepeviridae, is the major cause of several outbreaks of waterborne hepatitis in tropical and subtropical countries and of sporadic cases of viral hepatitis in endemic and industrialized countries. Transmission of HEV occurs predominantly ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.21116

    authors: Mushahwar IK

    更新日期:2008-04-01 00:00:00

  • A bioinformatic prediction of antigen presentation from SARS-CoV-2 spike protein revealed a theoretical correlation of HLA-DRB1*01 with COVID-19 fatality in Mexican population: An ecological approach.

    abstract::SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26561

    authors: Romero-López JP,Carnalla-Cortés M,Pacheco-Olvera DL,Ocampo-Godínez JM,Oliva-Ramírez J,Moreno-Manjón J,Bernal-Alferes B,López-Olmedo N,García-Latorre E,Domínguez-López ML,Reyes-Sandoval A,Jiménez-Zamudio L

    更新日期:2020-09-28 00:00:00

  • Increased serum levels of IL-33 and soluble ST2 in neonates with human cytomegalovirus infection.

    abstract::Interleukin 33 (IL-33) and soluble form of ST2 (sST2) are involved in inflammation. This study aimed to assess the role of serum IL-33 and sST2 in neonates with HCMV infection. The concentration of serum IL-33 and sST2 in 20 patients and 16 healthy controls were measure by enzyme-linked immune-sorbent assay (ELISA). T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25187

    authors: Chen Y,Qian J

    更新日期:2018-08-01 00:00:00

  • A chemiluminescent, magnetic particle-based immunoassay for the detection of hepatitis C virus core antigen in human serum or plasma.

    abstract::Hepatitis C virus (HCV) exposure in blood donors is determined serologically by the detection of anti-HCV antibodies in serum or plasma. However, a "window" period of 30-70 days after exposure exists where specific antibodies to HCV antigens are not detected. The use of nucleic acid testing for the detection of HCV RN...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20716

    authors: Leary TP,Gutierrez RA,Muerhoff AS,Birkenmeyer LG,Desai SM,Dawson GJ

    更新日期:2006-11-01 00:00:00

  • Genotyping of human papillomavirus in cervical intraepithelial neoplasia in a high-risk population.

    abstract::Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22057

    authors: Ili CG,Brebi P,López J,García P,Leal P,Suarez E,Roa JC

    更新日期:2011-05-01 00:00:00

  • Infection with GB virus C in patients with chronic liver disease.

    abstract::Infection with putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was surveyed in 286 patients with chronic liver disease in Japan. RNA of GBV-C was detected, by reverse-transcription polymerase chain reaction with nested primers from the 5'-noncoding region, in 19 patients (6.6%) at a frequency highe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sugai Y,Nakayama H,Fukuda M,Sawada N,Tanaka T,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期:1997-03-01 00:00:00

  • Recent trends in hepatitis A incidence in Brazil.

    abstract::Hepatitis A incidence has been decreasing in Brazil since child vaccination was implemented in 2014. This trend was interrupted by an outbreak among adult male in São Paulo in 2017. This study was outlined to estimate whether the increase of hepatitis A cases among adult men in Brazil was restricted to São Paulo. Case...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25694

    authors: De Oliveira TM,Vieira NSG,Sepp TDS,Souto FJD

    更新日期:2020-08-01 00:00:00

  • Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag-1.

    abstract::Human cytomegalovirus (HCMV) is an important opportunistic pathogen in immunocompromised individuals and is recognized as a major viral cause of birth defects. HCMV has the ability to establish lifelong persistence and latent infection following primary exposure. Apoptosis is an innate cellular defense response to vir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24259

    authors: Li HP,Yuan CL,Zho YC

    更新日期:2015-11-01 00:00:00

  • Diagnosis of enterovirus 70 infection by demonstration of IgM antibodies.

    abstract::Since outbreaks of severe acute hemorrhagic conjunctivitis occur worldwide [Hierholzer and Hatch, 1985] and the majority of the epidemics are caused by enterovirus 70 (EV-70), we developed an EV-70 IgM ELISA to simplify the diagnosis of these outbreaks. The test is based on the capture antibody technique and the use o...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890210404

    authors: Wulff H,Anderson LJ,Pallansch MA,de Souza Carvalho RP

    更新日期:1987-04-01 00:00:00

  • No evidence of Polyomavirus and EBV infections in Italian patients with mixed cryoglobulinemia infected chronically with HCV.

    abstract::Mixed cryoglobulinemia is a lymphoproliferative disorder associated with hepatitis C virus (HCV). In patients chronically affected by HCV the prevalence of mixed cryoglobulinemia is variable ranging from 0% to 56%. To verify whether polyomaviruses (PyV) play a role in this disorder a total of 222 blood samples from 63...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23867

    authors: Comar M,Zanotta N,Del Savio R,Vascotto F,Calabrese N,Zorat F,Pozzato G

    更新日期:2014-04-01 00:00:00

  • A novel real-time PCR system for simultaneous detection of human viruses in clinical samples from patients with uncertain diagnoses.

    abstract::A novel simultaneous detection system for human viruses was developed using a real-time polymerase chain reaction (PCR) system to identify causes of infection in clinical samples from patients with uncertain diagnoses. This system, designated as the "multivirus real-time PCR," has the potential to detect 163 human vir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21962

    authors: Katano H,Kano M,Nakamura T,Kanno T,Asanuma H,Sata T

    更新日期:2011-02-01 00:00:00

  • Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue.

    abstract::An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890330107

    authors: Kajino K,Ohta Y,Miyamura T,Saito I

    更新日期:1991-01-01 00:00:00

  • Detection of viral antigens in cerebrospinal fluid of patients with herpes simplex virus encephalitis.

    abstract::Thirty-two cerebrospinal fluid (CSF) samples from eighteen patients with confirmed herpes simplex encephalitis (HSE) were assayed by an indirect enzyme-linked immunosorbent assay (ELISA) for the presence of viral antigens. The results are expressed as an antigen ratio distinguishing between herpes simplex virus (HSV) ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890210209

    authors: Bos CA,Olding-Stenkvist E,Wilterdink JB,Scheffer AJ

    更新日期:1987-02-01 00:00:00

  • Serological evaluation of possible exposure to Ljungan virus and related parechovirus in autoimmune (type 1) diabetes in children.

    abstract::Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, usin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24127

    authors: Nilsson AL,Vaziri-Sani F,Broberg P,Elfaitouri A,Pipkorn R,Blomberg J,Ivarsson SA,Elding Larsson H,Lernmark Å

    更新日期:2015-07-01 00:00:00

  • Low incidence and high titers of antibodies to hepatitis B virus X-protein in sera of Chinese patients with hepatocellular carcinoma.

    abstract::Sera of patients from China with hepatocellular carcinoma (HCC) were tested for the presence of HBc/HBe- and HBx antibodies by immunoblotting using recombinant MS2 or beta gal fusion proteins as substrate. Antibodies against HBx were detected in four out of 68 HBsAg positive and in one out of three HBsAg negative sera...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890250310

    authors: Liang XH,Stemler M,Will H,Braun R,Tang ZY,Schröder CH

    更新日期:1988-07-01 00:00:00

  • Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data.

    abstract::Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction, and sputum) and lower (bronchoalveolar washings) respiratory t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24794

    authors: Stelzer-Braid S,Liu N,Doumit M,D'Cunha R,Belessis Y,Jaffe A,Rawlinson WD

    更新日期:2017-08-01 00:00:00

  • Coxsackie B virus-specific IgM responses in coronary care unit patients.

    abstract::An enzyme-linked immunosorbent assay (ELISA) test using polyvalent antigens and antisera was used to detect Coxsackie B virus-specific IgM responses in 329 patients admitted to the Coronary Care Unit, Wellington Hospital, New Zealand over a 12-month period. The sera of 30 of 153 (19.6%) patients with acute myocardial ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890180211

    authors: Lau RC

    更新日期:1986-02-01 00:00:00