Abstract:
:To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok, Thailand) were analyzed. Phylogenetic and likelihood-mapping analyses of these genome sequences were performed. On the basis of our results, the star-like signal and topology of 2019-nCoV may be indicative of potentially large "first generation" human-to-human virus transmission. We estimated that 2019-nCoV likely originated in Wuhan on 9 November 2019 (95% credible interval: 25 September 2019 and 19 December 2019), and that Wuhan is the major hub for the spread of the 2019-nCoV outbreak in China and elsewhere. Our results could be useful for designing effective prevention strategies for 2019-nCoV in China and beyond.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Li X,Zai J,Wang X,Li Ydoi
10.1002/jmv.25693subject
Has Abstractpub_date
2020-04-01 00:00:00pages
448-454issue
4eissn
0146-6615issn
1096-9071journal_volume
92pub_type
评论,杂志文章abstract::The prevalence of picobirnaviruses (PBVs) in human stools was investigated by polyacrylamide gel electrophoresis (PAGE) analysis of 832 faecal specimens collected between 1982 and 1993 from patients in various clinical groups. Similar prevalences (9-13%) were detected in patients with or without gastroenteritis and th...
journal_title:Journal of medical virology
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abstract::Varicella zoster-virus (VZV) is a humanpathogenic alpha-Herpesvirus that causes chickenpox after primary infection. The virus spreads by aerosol or direct contact with infectious vesical fluids, it enters the body via the respiratory tract. In a first viremic stage it replicates in local lymph nodes, followed by a sec...
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journal_title:Journal of medical virology
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doi:10.1002/jmv.1890140212
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journal_title:Journal of medical virology
pub_type: 杂志文章
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journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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doi:10.1002/jmv.25458
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22239
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abstract::The mechanisms underlying chronicity of hepatitis C virus (HCV) infection are poorly understood, but the importance of impaired viral clearance by the immune system has been suggested. The prevalence of HCV infection of peripheral blood mononuclear cells (PBMC) was in investigated in 34 persistently infected patients ...
journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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abstract::Serial serum samples from 16 Italian patients presenting with acute hepatitis C virus (HCV) infections (which progressed to chronic hepatitis in six) were screened for the non-organ-specific autoantibodies most frequently associated with autoimmune hepatitis (AIH), as well as for antibodies against the hepatic asialog...
journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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journal_title:Journal of medical virology
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abstract::Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the Crimean-Congo hemorrhagic fever virus. Long non-coding RNAs (lncRNAs) are generally classified as transcripts longer than 200 nucleotides (nt). The various lncRNAs expressed in infected cells are responsible for regulating the expression of v...
journal_title:Journal of medical virology
pub_type: 杂志文章
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journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
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