Abstract:
:A cohort of 127 nursing home residents aged 60-98 years were vaccinated during the winter of 1985-86 with the A-Chile 1/83 (C), A-Philippines 2/82 (P), and B-USSR (B) commercial influenza vaccines. Before vaccination 40%, 23%, and 69% were susceptible to influenza Ac, Ap, and B, respectively [hemagglutinin inhibition (H.I.) titer less than 1:40]. One month following initial vaccination, 32 patients [25%] remained unprotected against two or all three vaccine strains. These patients were revaccinated with the same influenza vaccine and followed up. At five months 11%, 19%, and 23% of the initial cohort were still unprotected against Ac, Ap, and B strains, respectively. We conclude that two conventional influenza vaccines administered one month apart leave unprotected 30% of healthy elderly people who are initial influenza vaccine failures.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Keren G,Segev S,Morag A,Zakay-Rones Z,Barzilai A,Rubinstein Edoi
10.1002/jmv.1890250112subject
Has Abstractpub_date
1988-05-01 00:00:00pages
85-9issue
1eissn
0146-6615issn
1096-9071journal_volume
25pub_type
杂志文章abstract::Hepatitis B virus (HBV) genotypes impact treatment outcomes and disease progression. The current genotyping methods have limitations in patients with low HBV viral load. In this study, a more sensitive assay has been developed for determining the HBV genotype in HBV DNA suppressed patients. Fifty-five serum samples fr...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26249
更新日期:2020-07-01 00:00:00
abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23728
更新日期:2014-02-01 00:00:00
abstract::This is an audit of a new technique to improve the colposcopy service. Samples were tested for high risk HPV DNA using Digene Hybrid Capture II. Sixty-four percent of the sampled women under 30 had detectable high risk HPV DNA, decreasing to 44% in 30--39 year olds and to 27% in women over 40. High risk HPV prevalence...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20401
更新日期:2005-08-01 00:00:00
abstract::Noroviruses (NoVs) are a leading cause of acute gastroenteritis outbreaks and sporadic cases of diarrhea in industrialized countries. To study the prevalence and genetic diversity of NoVs in Guatemala, stool specimens were collected from hospitalized and ambulatory patients presenting with diarrhea (≥3 loose or liquid...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23578
更新日期:2013-07-01 00:00:00
abstract::An outbreak of dengue type 2 occurred in North Queensland, Australia, between December 1996 and April 1997. Culture of serum in the Aedes albopictus C6/36 cell line with detection using immunofluorescent staining was compared with a culture-amplified detection system using an immunoperoxidase staining method in a micr...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:1999-02-01 00:00:00
abstract::Immune-specific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95% of HSV-seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 1981]. However, herpes virus-induced immune-specific IFN was produced by PBML from only 33 of 48 (68.8%) pe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890160311
更新日期:1985-07-01 00:00:00
abstract::In 2000, we monitored the course and persistence of human papillomavirus (HPV) infection in 54 women who were HPV positive and free of any cytological disease using HPV-DNA genotyping with a linear array assay (baseline). The impact of HPV infection on development of cervical cytological abnormality (dyskaryosis) was ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20062
更新日期:2004-05-01 00:00:00
abstract::Complete coding regions were sequenced for two new enterovirus genomes: EV-B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV-C95 from a French soldier with acute gastroenteritis in Djibouti. The EV-B93 P1 had more than 30% nucleot...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24062
更新日期:2015-03-01 00:00:00
abstract::To investigate whether the administration of IL-12 is effective against influenza virus infection, mice were intranasally administered IL-12 for three consecutive days and then infected with a non-lethal dose of the influenza virus. The IL-12-treated mice were more resistant to the virus than control mice with respect...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24494
更新日期:2016-09-01 00:00:00
abstract::The natural history of chronic hepatitis B virus (HBV) infection is highly variable, ranging from a benign course to one of shortened life expectancy. Liver histology represents an accurate tool for assessing progressive liver disease, and has been used in five recent Phase III clinical trials of the oral nucleoside a...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:
更新日期:2000-07-01 00:00:00
abstract::A viral surveillance system in Nashville detected an outbreak of influenza B that occurred between January and March 1986. Paired sera from 32 individuals with culture-documented influenza B illness were tested using three serologic assays. Enzyme-linked immunosorbent assay (ELISA) using purified hemagglutinin-neurami...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章
doi:10.1002/jmv.1890250313
更新日期:1988-07-01 00:00:00
abstract::Citrullinated histone H3 (H3Cit) is the product of the conversion of peptidylarginine to citrulline in histone H3. We evaluated the H3Cit level in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) tissues and assessed its association with Beclin1 messenger RNA (mRNA) (a key autophagic regulator). The leve...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25663
更新日期:2020-08-01 00:00:00
abstract::The nature of the immunodominant a region of hepatitis B virus surface antigen (HBsAg) has been examined by mutation of specific amino acid residues. Proline 142 was required for the exhibition of full antigenicity. Replacement of cysteines 124 and 147 by serines drastically reduced or eliminated reactivity with antib...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890290310
更新日期:1989-11-01 00:00:00
abstract::Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16
更新日期:1999-10-01 00:00:00
abstract::The present study compared the efficacy of standard and extended durations of PEG-IFNα-2a monotherapy for treatment of HBeAg-negative Chinese patients with chronic hepatitis B. Patients were randomized to receive standard therapy (n = 38; 48 weeks treatment) or extended therapy (n = 42; 72 weeks treatment). Extended t...
journal_title:Journal of medical virology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jmv.24013
更新日期:2014-10-01 00:00:00
abstract::Human T-cell lymphotropic virus (HTLV) antibody screening is not recommended uniformly before transplantation in Western countries. In the year 2001, the first cases of HTLV-I infection acquired through organ transplantation from one asymptomatic carrier were reported in Europe. All three organ recipients developed a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20331
更新日期:2005-06-01 00:00:00
abstract::Hepatitis C virus genotype 4 (HCV-4) is highly prevalent in Spain, but the information on the molecular characterization of HCV-4 in this region is scarce. Due to this, the molecular characteristics and the evolution of HCV-4 infection in Seville were analyzed (Southern Spain) and compared them with samples from Madri...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23657
更新日期:2013-10-01 00:00:00
abstract::In early 2008, a sudden increase in oseltamivir (Tamiflu)-resistant influenza A H1N1 viruses was reported from several European countries. This resistant virus has spread globally and accounted for more than 95% of H1N1 viruses isolated in the following influenza season. A continuous close monitoring on the prevalence...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21783
更新日期:2010-08-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21629
更新日期:2010-01-01 00:00:00
abstract::Sexually transmitted disease (STD) remains a major public health challenge in developed countries, exacerbated by the advent of the HIV epidemic. The objectives of this study were to assess the prevalence of serological markers of syphilis, HIV-1/2, HTLV-I/II, HBV, and HCV infections among immigrant sex workers in Mad...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20208
更新日期:2004-12-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2017-08-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2003-02-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21342
更新日期:2009-03-01 00:00:00
abstract::Concomitant infection with TT virus and hepatitis B virus (HBV) or hepatitis C virus (HCV) is common. However, the effect of TTV infection on chronic hepatitis B or C is unknown. The prevalence of TTV infection, the effect of TTV infection on the clinical, histological and virological features of patients with chronic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200004)60:4<387::aid-jmv4>
更新日期:2000-04-01 00:00:00
abstract::Hepatitis C virus core antigen (HCVcoreAg) may be measured in serum with a sensitive, recently validated assay. Beyond its value as a marker of viral infection, there are little data on its relation with clinical, histological, and virological parameters. In this study, the significance of HCVcoreAg levels was studied...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23672
更新日期:2013-11-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21374
更新日期:2009-02-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200103
更新日期:1986-09-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23880
更新日期:2014-12-01 00:00:00
abstract::Total RNA from normal adult woodchucks was analyzed using membrane arrays containing human cDNA clones, and the gene expression patterns were compared to human liver. Various hybridization and wash conditions were examined. In both the woodchuck and human livers, 352 genes were identified as highly expressed (Z-scores...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20186
更新日期:2004-10-01 00:00:00
abstract::The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the inter...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199905)58:1<11::aid-jmv2>3
更新日期:1999-05-01 00:00:00