Abstract:
:Immune-specific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95% of HSV-seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 1981]. However, herpes virus-induced immune-specific IFN was produced by PBML from only 33 of 48 (68.8%) persons with frequent recurrences (2-12 episodes a year). Two of eight subjects with primary herpes gingivostomatitis also failed to produce immune-specific IFN during either the acute or convalescent phases of their initial HSV infection. These data suggest that some persons have a defective immune-specific IFN response that exists from the time of their primary oro-labial HSV type 1 infection. This defect may predispose to a higher frequency of disease in some individuals.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Green JA,Weiss PN,Yeh TJ,Spruance SLdoi
10.1002/jmv.1890160311subject
Has Abstractpub_date
1985-07-01 00:00:00pages
297-305issue
3eissn
0146-6615issn
1096-9071journal_volume
16pub_type
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