Abstract:
:Parechoviruses are emerging pathogens of humans often affecting the pediatric age group, with a growing line of evidence implicating them as agents of a broad spectrum of clinical syndromes in adults. However, because many clinicians are not familiar with the manifestation of the infections, they are not included in the list of diagnostic pathogens. Furthermore, due to the indistinguishable feature of the infection compared with other common pathogens, a large number of cases are likely to go unchecked. Some may develop asymptomatic infection and recover without overt clinical disease. In this manuscript, we reviewed available literature on parechovirus infection in adult and summarized information relating to epidemiology, clinical manifestation, laboratory diagnosis, and therapeutics. The information provided should help in early case detection and support an evidence-based clinical decision.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Kabuga AI,Nejati A,Soheili P,Shahmahmoodi Sdoi
10.1002/jmv.26395subject
Has Abstractpub_date
2020-08-06 00:00:00eissn
0146-6615issn
1096-9071pub_type
杂志文章,评审abstract::During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta-response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24524
更新日期:2016-10-01 00:00:00
abstract::Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in immunocompromised patients, such as renal transplant recipients. Analysis of the gene encoding the envelope glycoprotein B (gB) showed that clinical isolates adopted one of the sequence configurations, permitting the isolates to be assigned a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10383
更新日期:2003-06-01 00:00:00
abstract::Recent studies have shown an association between single nucleotide polymorphisms (SNPs) in the interferon lambda-3 (IFNL3 or IL-28B) and IFNL4 genes and treatment response to hepatitis C virus genotype 1 (HCV-1) infection. The importance of these SNPs for HCV genotype 3 (HCV-3), and particularly HCV genotype 6 (HCV-6)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23957
更新日期:2014-09-01 00:00:00
abstract::Hepatitis B virus (HBV) infection is a dynamic process during which molecular variants are selected continuously to adapt to changes. In addition to drug resistant mutations, sequential antiviral therapy may also lead to the selection of deleted mutants. To investigate this process, the following samples were collecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21595
更新日期:2009-09-01 00:00:00
abstract::The prevalence of HCV genotypes in four republics of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan) was investigated. Overall, 197 HCV isolates from 66 blood donors and 131 patients with chronic hepatitis were typed. Viral sequences from sera of infected subjects were amplified by nested RT-PCR usi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-09-01 00:00:00
abstract::Human herpes virus type 6 (HHV-6) DNA has been suggested to be a cofactor to human papillomavirus (HPV) in cervical cancer. In a cross-sectional study, we investigated the association between HHV-6 DNA detected in cervical brushings and high-grade squamous intraepithelial lesions (HSIL), while controlling for genital ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10229
更新日期:2002-12-01 00:00:00
abstract::Total RNA from normal adult woodchucks was analyzed using membrane arrays containing human cDNA clones, and the gene expression patterns were compared to human liver. Various hybridization and wash conditions were examined. In both the woodchuck and human livers, 352 genes were identified as highly expressed (Z-scores...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20186
更新日期:2004-10-01 00:00:00
abstract::A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucle...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract::Human papillomavirus (HPV) is known to be the cause of almost all cervical cancers. The genotypes have been classified into high and low risk types according to their oncogenic potential. However, data for many of the genotypes are limited and some (HPV-26, 53, and 66) have no agreed status. A study was undertaken to ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20330
更新日期:2005-05-01 00:00:00
abstract::Using the RT-PCR with primers that anneal to the 5' and the 3' extremities of the genome segments of bunyaviruses and internal primers that anneal to the S segment of Simbu serogroup viruses in a nested PCR it was possible to amplify the Oropouche virus (ORO) genome from the sera of three patients. These results show ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2122
更新日期:2002-01-01 00:00:00
abstract::An outbreak of an acute sporadic viral hepatitis occurring at three villages in the lower Shebli region of southern Somalia was studied. Sera were examined for antibodies to hepatitis E virus (HEV) antigen by a recently developed enzyme-linked immunosorbent assay. The prevalence of anti-HEV ranged from 77.8% to 94.0% ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890400309
更新日期:1993-07-01 00:00:00
abstract::The general aim was to investigate the burden of respiratory virus illness in a hospital emergency department, during two different epidemic seasons. Consecutive patients attending an emergency department during two study periods (February/March 2009 and 2010) were enrolled using broad inclusion criteria (fever/preced...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22205
更新日期:2011-11-01 00:00:00
abstract::Varicella zoster-virus (VZV) is a humanpathogenic alpha-Herpesvirus that causes chickenpox after primary infection. The virus spreads by aerosol or direct contact with infectious vesical fluids, it enters the body via the respiratory tract. In a first viremic stage it replicates in local lymph nodes, followed by a sec...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10323
更新日期:2003-01-01 00:00:00
abstract::Early estimates of the prevalence of TTV viremia in healthy adults of developed countries were in the order of 1--10 %, while similar estimates in Third World countries were considerably higher. Using three different PCRs, TTV-related DNA was detected in serum from 180 out of the 201 Norwegian blood donors tested, ind...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1062
更新日期:2001-07-01 00:00:00
abstract::We studied the role of sexual transmission in the epidemiology of HCV by a cross-sectional study comparing prostitutes and HCV seropositive and seronegative sexual clients recruited from the bordellos of the docks of Santos, São Paulo State. The average age in the prostitute group was 27.2 years. The median time spent...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract::Mixed cryoglobulinemia is a lymphoproliferative disorder associated with hepatitis C virus (HCV). In patients chronically affected by HCV the prevalence of mixed cryoglobulinemia is variable ranging from 0% to 56%. To verify whether polyomaviruses (PyV) play a role in this disorder a total of 222 blood samples from 63...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23867
更新日期:2014-04-01 00:00:00
abstract::Rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative PCRs. Quantitative PCR assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21095
更新日期:2008-03-01 00:00:00
abstract::The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21461
更新日期:2009-04-01 00:00:00
abstract::The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demons...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.1890410526
更新日期:1993-01-01 00:00:00
abstract::To characterize the state of dual infection with hepatitis B virus (HBV) and hepatitis C virus (HCV), HBV-DNA and HCV-RNA levels were determined by spot hybridization or polymerase chain reaction in the sera of patients who were positive for both hepatitis B surface antigen and HCV antibody. Among 27 patients who show...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890450222
更新日期:1995-02-01 00:00:00
abstract::Alfa-fetoprotein (AFP) is used as a marker of early hepatocarcinogenesis. However, the impact of hepatitis B virus surface antigen (HBsAg) on this relationship in patients with HBV infection is not clear. The present study evaluated the relation between HBsAg and AFP levels at the initial visit in 1,610 untreated HBV ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23790
更新日期:2014-01-01 00:00:00
abstract::During the 1976 Ebola virus outbreak in Sudan, the investigations team gained the impression that fewer haemorrhagic manifestations and few fatalities occurred during the later stages of the epidemic after the virus had undergone several generations in man. This impression was also noted in guinea pigs experimentally ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890060205
更新日期:1980-01-01 00:00:00
abstract::Puumala and Tula viruses are hantaviruses found in Europe and are associated with the rodents Clethrionomys glareolus and Microtus arvalis, respectively. Puumala virus is associated with the human disease nephropathia epidemica. In Austria, ten clinically diagnosed cases of nephropathia epidemica, presumably caused by...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199710)53:2<174::aid-jmv11
更新日期:1997-10-01 00:00:00
abstract::Eastern equine encephalitis (EEE) is rare, but the most severe of the mosquito-borne encephalitides in the United States with a high case fatality rate of 30%. Here, we present a patient with EEE. EEE virus causes sporadic human disease in the Eastern parts of the United States, but the case we describe was a Scottish...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21379
更新日期:2009-02-01 00:00:00
abstract::The competitive ELISA test was compared with competitive RIA, complement fixation, and indirect fluorescent antibody test for the detection of antibody to varicella-zoster virus (VZV). ELISA and RIA were the most sensitive tests, being tenfold as sensitive as indirect immunofluorescence and 20 times as sensitive as co...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130407
更新日期:1984-01-01 00:00:00
abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21304
更新日期:2008-12-01 00:00:00
abstract::The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199911)59:3<364::aid-jmv17
更新日期:1999-11-01 00:00:00
abstract::Outbreaks of gastroenteritis are a major public health problem in New Zealand. The introduction of molecular detection methods has now shown that the 'Norwalk-like viruses' (NLVs) are the major cause of food and waterborne nonbacterial gastroenteritis. Reverse transcription and polymerase chain reaction (RT-PCR) were ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1018
更新日期:2001-05-01 00:00:00
abstract::We previously reported an age-associated impairment of serum immunoglobulin G (IgG) antibody responses to inactivated influenza virus vaccine. The present study extends these observations by examining the IgG subclass distribution of vaccine responses measured by enzyme linked immunosorbent assay in healthy adults age...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430111
更新日期:1994-05-01 00:00:00
abstract::The incidence and the outcome of cytomegalovirus (CMV) infections were evaluated in 83 adult recipients of allogenic bone marrow transplantation. Virological and serological surveillance was performed weekly for 3 months posttransplant, and then every other week or every month until 1 year. CMV infection occurred in 4...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230412
更新日期:1987-12-01 00:00:00