Abstract:
:During the 1976 Ebola virus outbreak in Sudan, the investigations team gained the impression that fewer haemorrhagic manifestations and few fatalities occurred during the later stages of the epidemic after the virus had undergone several generations in man. This impression was also noted in guinea pigs experimentally infected with Sudanese and Zairean strains of Ebola virus. The virulence of the Sudanese isolates was less intense than isolates emanating from Zaire. Similar findings were seen in monkeys; a Zairean isolated produced fatal infections, whereas monkeys inoculated with a Sudan strain generally recovered. Two monkeys, which had recovered from Sudanese strain infections and had developed high levels of antibody detectable by immunofluorescence, were challenged with the Zairean strain. Both developed viraemias and died. The mechanisms of this "failed protection" are discussed.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Bowen ET,Platt GS,Lloyd G,Raymond RT,Simpson DIdoi
10.1002/jmv.1890060205subject
Has Abstractpub_date
1980-01-01 00:00:00pages
129-38issue
2eissn
0146-6615issn
1096-9071journal_volume
6pub_type
杂志文章abstract::Recent epidemiological and immunohistochemical studies have indicated a possible link between measles virus and inflammatory bowel disease (IBD). The aim of this study was to use a sensitive and robust method for the detection of measles virus RNA in IBD and control clinical samples. Peripheral blood mononuclear cells...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
abstract::Persisting human papillomavirus (HPV) infection is a critical step in cervical carcinogenesis. This study was conducted to determine the type-specific HPV persistence and risk factors for persistence of high-risk HPV infections in a large cohort of Danish women. The study was based on a population-based prospective co...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21750
更新日期:2010-04-01 00:00:00
abstract::Hepatitis A virus (HAV) is usually transmitted by an oral-fecal route and is prevalent not only in developing countries but also in developed countries. In the present study, the phylogenetic characterization of the VP1/2A junction region (321 nucleotides) of China HAV isolates was examined. Anti-HAV IgM-positive seru...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22086
更新日期:2011-07-01 00:00:00
abstract::High risk types of human papillomaviruses E6/E7 oncogenes and their association with tumor suppressor genes products are the key factors of cervical carcinogenesis. This study proposed them as specific markers for cervical dysplasia screening. The aim of the study is to compare the clinical and prognostic significance...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24199
更新日期:2015-09-01 00:00:00
abstract::A 31-year-old woman contracted acute varicella at 13 weeks of gestation. Severe hydrops fetalis, hepatomegaly, and intrauterine fetal death were detected at 16 weeks of gestation by ultrasound examinations. An examination at autopsy, histopathology, and polymerase chain reaction (PCR) provided evidence of varicella-zo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23531
更新日期:2013-05-01 00:00:00
abstract::Human herpesviruses (HHVs) are involved in the pathogenesis of different types of uveitis. Cytokine response plays an important role in virus-induced immunopathology. This study aimed to investigate the incidence of HHVs in aqueous humor samples of immunocompetent patients with suspected viral uveitis and cytokine (IL...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23708
更新日期:2013-12-01 00:00:00
abstract::GB virus C (GBV-C) is related to hepatitis C virus (HCV) and has a similar genomic structure. Some predictors for the efficacy of interferon (IFN) therapy on HCV have been reported: genotype, viral load, IFN dose, and the amino acid substitutions in the NS5A region, designated as the interferon sensitivity determining...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199904)57:4<376::aid-jmv9>
更新日期:1999-04-01 00:00:00
abstract::To define better the human immune response to individual structural proteins of human cytomegalovirus (HCMV), 55 human sera with different IgG and IgM titres were studied for their reactivity with HCMV structural polypeptides separated by SDS-PAGE and electrotransferred to nitrocellulose paper. The results obtained sh...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170403
更新日期:1985-12-01 00:00:00
abstract::There are very few studies in search of an alternate and convenient diagnostic tool which can substitute nasopharyngeal swab (NPS) specimen for detection of SARS-CoV-2. In the study we analyzed, the comparison and agreement between the feasibility of using the saliva in comparison to NPS for diagnosis of SARS-CoV-2. A...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26719
更新日期:2020-12-09 00:00:00
abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199608)49:4<283::AID-JMV5>
更新日期:1996-08-01 00:00:00
abstract::Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this r...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23326
更新日期:2012-08-01 00:00:00
abstract::Long-term treatment with retrotranscriptase (RT) inhibitors eventually leads to the development of drug resistance. Drug-related mutations occur naturally and these can be found in hepatitis B virus (HBV) carriers who have never received antiviral therapy. HBsAg are overlapped with RT domain, thus nucleot(s)ide analog...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24098
更新日期:2015-06-01 00:00:00
abstract::Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS). Several studies indicate horizontal HHV-8 transmission among children in areas where KS is endemic, but few studies have assessed acquisition of HHV-8 by children in low seroprevalence areas. Antibody screening was carried out for HHV-8 and E...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10548
更新日期:2004-01-01 00:00:00
abstract::Human bocavirus (HBoV) was first recognized in respiratory samples in 2005. The clinical importance of HBoV infection remains unclear. This report describes the clinical features and molecular phylogeny of HBoV isolates in children with acute respiratory infections. Nasopharyngeal aspirates were obtained from 1,528 ch...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23880
更新日期:2014-12-01 00:00:00
abstract::The Markov model was introduced to simulate natural histories of hepatitis C virus (HCV) infection in men and women. The data set was constructed on 942 HCV carriers who were examined at least once a year without receiving antiviral therapies. Based on 2,251 patient-year data, the probabilities of transition between a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10406
更新日期:2003-07-01 00:00:00
abstract::Rotavirus vaccines have been available in Japan since 2011. This study conducted to monitor the trend of group A rotavirus (RVA) genotypes 3 years after vaccine introduction. A total of, 539 fecal samples were collected from children with acute gastroenteritis in six regions during July 2014-June 2015. Among them, 178...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25067
更新日期:2018-06-01 00:00:00
abstract::A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20363
更新日期:2005-07-01 00:00:00
abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20872
更新日期:2007-09-01 00:00:00
abstract::This study aimed to examine the baseline prevalence of genital human papillomavirus (HPV) infection among human immunodeficiency virus (HIV)-seropositive men who have sex with men in Taiwan and to determine the association of age and CD4+ T cell counts with HPV infection. In 2010, 305 men who have sex with men infecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23413
更新日期:2012-12-01 00:00:00
abstract::The incidence and the outcome of cytomegalovirus (CMV) infections were evaluated in 83 adult recipients of allogenic bone marrow transplantation. Virological and serological surveillance was performed weekly for 3 months posttransplant, and then every other week or every month until 1 year. CMV infection occurred in 4...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230412
更新日期:1987-12-01 00:00:00
abstract::Stored demographic data and HIV RT and protease sequences of 877 HIV patients attending for the first time the HIV/AIDS outpatient clinics of a reference Infectious Diseases centre in Northern Italy between 1999 and 2006 were stratified by 3-year spanning periods according to date of HIV infection. In the period 1980-...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21163
更新日期:2008-06-01 00:00:00
abstract::Because Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogen...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10254
更新日期:2003-01-01 00:00:00
abstract::The purpose of this study was to evaluate the use of dried blood spots stored on filter paper as a means to provide specimens for virologic surveillance for measles virus (MV) in situations when the reverse cold chain is not available. Two single-step RT-PCR assays were evaluated for sensitivity of detection of MV nuc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10144
更新日期:2002-08-01 00:00:00
abstract::One hundred thirty-two strains of adenovirus type 7 were isolated in Hiroshima City during the period 1995-1999. About 80% of the viruses were isolated from patients with respiratory illness, and about 70% were isolated from children younger than 6 years old. DNA restriction analysis was performed on 58 of the 132 iso...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10287
更新日期:2003-02-01 00:00:00
abstract::Virus fragments homologous to TTV were detected previously from an enterically transmitted outbreak of non-A-E hepatitis [Luo et al., 1999]. To test the susceptibility of the Rhesus monkey to this virus and to establish its transmission routes, 6 Rhesus monkeys were inoculated, 3 orally and another 3 intravenously. Th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26
更新日期:2000-05-01 00:00:00
abstract::Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890350105
更新日期:1991-09-01 00:00:00
abstract::The Gaza Strip borders the southern part of Israel and Egypt. There is a remarkable difference in the prevalence of antibodies to hepatitis C virus (HCV) between Israel (0.5%) and Egypt (10%). A few thousand inhabitants cross the borders daily from the Gaza Strip to both countries. The objectives of this study were to...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199811)56:3<230::aid-jmv9>
更新日期:1998-11-01 00:00:00
abstract::In countries with a low prevalence of human T-lymphotropic virus (HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-ind...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Rotavirus-specific subclass antibody responses and cytokines, tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-8 (IL-8), and IL-10, were measured in children 7-24 months of age with rotavirus diarrhoea (n = 29); the responses were compared with children with watery diarrhoea from who...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10280
更新日期:2003-02-01 00:00:00
abstract::The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25035
更新日期:2018-05-01 00:00:00