Incidence and prognosis of cytomegalovirus infections following allogenic bone marrow transplantation.

Abstract:

:The incidence and the outcome of cytomegalovirus (CMV) infections were evaluated in 83 adult recipients of allogenic bone marrow transplantation. Virological and serological surveillance was performed weekly for 3 months posttransplant, and then every other week or every month until 1 year. CMV infection occurred in 45 patients, with a cumulative risk of 62% at 1 year and 66% at 2 years. In multivariate analysis, two factors significantly influenced the incidence of CMV infection: patients with pretransplant positive anti-CMV titres had a risk of infection of 72% at 1 year versus 33% for patients with negative titres. Patients with acute myeloid leukemia were also infected more frequently (85% at 1 year) than patients with acute lymphoblastic leukemia (56%), chronic granulocytic leukemia (45%), or aplastic anemia (47%). In both univariate and multivariate analysis, CMV infection was not associated with a worse prognosis. However, 5 (out of 10) cases of lethal interstitial pneumonitis were associated with CMV, and two patients died of possible CMV encephalitis. All these patients had been suffering from severe acute or chronic graft versus host disease.

journal_name

J Med Virol

authors

Guyotat D,Gibert R,Chomel J,Archimbaud E,Bossard S,Maupas J,Fiere D,Aymard M

doi

10.1002/jmv.1890230412

subject

Has Abstract

pub_date

1987-12-01 00:00:00

pages

393-9

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

23

pub_type

杂志文章
  • Fulminant demyelinating encephalomyelitis associated with productive HHV-6 infection in an immunocompetent adult.

    abstract::Human herpesvirus 6 (HHV-6), the etiologic agent of roseola in young children, has been reported to be detectable in the brain of many neurologically normal adults, although regional localization to plaques of multiple sclerosis has also been demonstrated. Large amounts of this virus were present in multifocal demyeli...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199707)52:3<301::aid-jmv11

    authors: Novoa LJ,Nagra RM,Nakawatase T,Edwards-Lee T,Tourtellotte WW,Cornford ME

    更新日期:1997-07-01 00:00:00

  • A novel preservative-free seasonal influenza vaccine safety and immune response study in the frame of preclinical research.

    abstract::The paper describes the results of preclinical testing of the preparation "Vaccine allantoic split-virus inactivated against seasonal influenza." Acute toxicity and local irritating effect, anaphylactic reactions to different antigens (vaccine and ovalbumin), delayed-type hypersensitivity to ram erythrocytes, humoral ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24771

    authors: Sarsenbayeva G,Volgin Y,Kassenov M,Issagulov T,Bogdanov N,Nurpeisova A,Sagymbay A,Abitay R,Stukova M,Sansyzbay A,Khairullin B

    更新日期:2017-07-01 00:00:00

  • Experimental CVB3-induced chronic myocarditis in two murine strains: evidence of interrelationships between virus replication and myocardial damage in persistent cardiac infection.

    abstract::In order to analyse the relationships between enteroviral replication and the myocardial damage at the onset of chronic cardiac infection, 2 mouse strains with different degrees of immunological competence (NMRI nu/nu, DBA/2) were infected by a myocarditic Coxsackie virus B3 (CVB3-M1) variant. At 31 days post-inoculat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199706)52:2<206::aid-jmv15

    authors: Andréoletti L,Hober D,Becquart P,Belaich S,Copin MC,Lambert V,Wattré P

    更新日期:1997-06-01 00:00:00

  • Human papillomavirus genotypes and their association with cervical neoplasia in a cohort of Western Australian women.

    abstract::Human papillomavirus (HPV) is known to be the cause of almost all cervical cancers. The genotypes have been classified into high and low risk types according to their oncogenic potential. However, data for many of the genotypes are limited and some (HPV-26, 53, and 66) have no agreed status. A study was undertaken to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20330

    authors: Brestovac B,Harnett GB,Smith DW,Shellam GR,Frost FA

    更新日期:2005-05-01 00:00:00

  • Altered expression of CXCR3 and CCR6 and their ligands in HTLV-1 carriers and HAM/TSP patients.

    abstract::Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were me...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24779

    authors: Rafatpanah H,Felegari M,Azarpazhooh MR,Vakili R,Rajaei T,Hampson I,Hassanshahi G,Valizadeh N,Gerayli S,Hamid F,Zamanian S,MollaHosseini F,Rezaee SA

    更新日期:2017-08-01 00:00:00

  • Identification of a novel human papillomavirus type 16 E1 gene variant with potentially reduced oncogenicity.

    abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21304

    authors: Sabol I,Matovina M,Gasperov NM,Grce M

    更新日期:2008-12-01 00:00:00

  • Prevalence of unusual human rotavirus strains in Ghanaian children.

    abstract::Sixty-seven rotavirus-positive fecal samples, collected between January and April 1999, from children with diarrhea in the Upper East Region of Ghana were examined for rotavirus VP7 and VP4 types. Sufficient viral RNA could be obtained from 46 (68.7%) of the samples and all the isolates had short electrophoretic patte...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Armah GE,Pager CT,Asmah RH,Anto FR,Oduro AR,Binka F,Steele D

    更新日期:2001-01-01 00:00:00

  • Long-term follow-up of patients with hepatitis C with a normal alanine aminotransferase.

    abstract::An attempt was made to identify factors influencing the cumulative probability of an increased alanine aminotransferase (ALT) level and hepatocarcinogenesis in hepatitis C patients with a normal ALT level initially. A total of 398 consecutive patients with a normal ALT level initially for 6 months or more and follow-u...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21342

    authors: Kumada T,Toyoda H,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Kanamori A,Atsumi H,Takagi M,Nakano S,Arakawa T,Fujimori M

    更新日期:2009-03-01 00:00:00

  • A new cluster of hepatitis A infection in hemophiliacs traced to a contaminated plasma pool.

    abstract::Recently, several clusters of hepatitis A have been observed among hemophiliacs linked to factor VIII concentrates treated for virus inactivation solely with the solvent/detergent (S/D) method, a procedure that does not affect nonenveloped viruses such as the hepatitis A virus (HAV). A new outbreak of hepatitis A in s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199902)57:2<91::aid-jmv1>3

    authors: Chudy M,Budek I,Keller-Stanislawski B,McCaustland KA,Neidhold S,Robertson BH,Nübling CM,Seitz R,Löwer J

    更新日期:1999-02-01 00:00:00

  • Active replication of human immunodeficiency virus type 1 by peripheral blood mononuclear cells following coincubation with herpes viruses.

    abstract::Patients with acquired immunodeficiency syndrome (AIDS) commonly suffer from opportunistic infections associated with members of the herpes virus family. To investigate whether certain of these other viruses might have an effect on the ability of the human immunodeficiency virus type 1 (HIV-1) to replicate, we coincub...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890290207

    authors: Tremblay M,Gornitsky M,Wainberg MA

    更新日期:1989-10-01 00:00:00

  • Cell-mediated immunity in respiratory syncytial virus disease.

    abstract::Systemic cell-mediated responses to respiratory syncytial (RS) virus were detected, using a whole blood transformation assay, in 10 of 28 infants and children with RS virus infections during the period 1-14 days postadmission. Cell-mediated responses were unrelated to the age of the patient or the severity of illness....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130112

    authors: Scott R,Pullan CR,Scott M,McQuillin J

    更新日期:1984-01-01 00:00:00

  • High circulating levels of N-terminal pro-brain natriuretic peptide and interleukin 6 in patients with mixed cryoglobulinemia.

    abstract::Many patients with mixed cryoglobulinemia and chronic HCV infection experience symptoms, such as dyspnea, which sometimes do not seem to indicate the involvement of the liver but rather the symptoms of heart failure. To our knowledge, there has been no other study evaluating the serum levels of N-terminal pro-brain na...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21636

    authors: Antonelli A,Ferri C,Ferrari SM,Ghiri E,Galetta F,Franzoni F,Santoro G,Fallahi P

    更新日期:2010-02-01 00:00:00

  • Two years outcome of women infected with high risk HPV having normal colposcopy following low-grade or equivocal cytological abnormalities: are HPV16 and 18 viral load clinically useful predictive markers?

    abstract::Management of patients infected with high-risk HPV (hrHPV) despite normal colposcopy following abnormal cytology remains a clinical challenge. The aim of this study was to evaluate if, in that specific population, initial HPV 16 and HPV 18 viral loads are predictive of infection clearance over a 24-month follow-up. A ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23276

    authors: Carcopino X,Henry M,Mancini J,Giusiano S,Boubli L,Olive D,Tamalet C

    更新日期:2012-06-01 00:00:00

  • Oyster-associated gastroenteritis in Australia: the detection of Norwalk virus and its antibody by immune electron microscopy and radioimmunoassay.

    abstract::Following widespread outbreaks of oyster-associated gastroenteritis in Australia during 1978 in which Norwalk virus was implicated as the causative agent, collaborative studies were undertaken between laboratories in Australia and the United States to confirm the etiology. Immune electron microscopy (IEM) techniques w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890060103

    authors: Grohmann GS,Greenberg HB,Welch BM,Murphy AM

    更新日期:1980-01-01 00:00:00

  • Combined detection and genotyping of Chikungunya virus by a specific reverse transcription-polymerase chain reaction.

    abstract::A reverse transcription-polymerase chain reaction (RT-PCR) was developed for the detection of Chikungunya virus infection. Based on the nonstructural protein 1 (nsP1) and glycoprotein E1 (E1) genes of Chikungunya, two primer sets were designed. Total RNA were extracted from the cell culture fluid of Aedes albopictus C...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10085

    authors: Hasebe F,Parquet MC,Pandey BD,Mathenge EG,Morita K,Balasubramaniam V,Saat Z,Yusop A,Sinniah M,Natkunam S,Igarashi A

    更新日期:2002-07-01 00:00:00

  • Molecular characterization of the env gene of two CCR5/CXCR4-independent human immunodeficiency 2 primary isolates.

    abstract::Human immunodeficiency virus 2 (HIV-2) infection is characterized by a slower disease progression and lower transmission rates. The molecular features that could be assigned as directly involved in this in vivo phenotype remain essentially unknown, and the importance of HIV-2 as a model to understand pathogenicity of ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21619

    authors: Santos-Costa Q,Parreira R,Moniz-Pereira J,Azevedo-Pereira JM

    更新日期:2009-11-01 00:00:00

  • Prevalence of high risk genital papillomaviruses in the Belgian female population determined by fast multiplex polymerase chain reaction.

    abstract::Because in situ/filter hybridisation is not sensitive enough and because classical polymerase chain reaction (PCR) protocols are generally not sufficiently reproducible and specific, there is little accurate information on the prevalence of human papillomaviruses (HPV) 16, 18, and 33 infections in women without dyskar...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890360409

    authors: Vandenvelde C,Scheen R,Van Pachterbeke C,Loriaux C,Decelle J,Hubert T,Delhaye C,Cattoor JP,Duys M,Van Beers D

    更新日期:1992-04-01 00:00:00

  • A-549 is a suitable cell line for primary isolation of coxsackie B viruses.

    abstract::A common receptor for coxsackie B virus and adenovirus has been described recently in cells of human and murine origin. Since the established cell line A-549 is suitable for adenoviruses, the potential use of A-549 cells for the isolation of coxsackie B viruses from clinical samples was investigated. All throat swabs ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Otero JR,Folgueira L,Trallero G,Prieto C,Maldonado S,Babiano MJ,Martinez-Alonso I

    更新日期:2001-11-01 00:00:00

  • Genomic and antigenic variation among rotavirus strains circulating in a large city of Argentina.

    abstract::Knowledge of the antigenic diversity of rotaviruses circulating in a region should be acquired before introducing a rotavirus vaccine. In a collection of 151 rotavirus-positive samples from Mendoza, Argentina, strain diversity was evaluated utilizing G-typing monoclonal antibodies (MAbs), reverse-transcriptase-polymer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Espul C,Cuello H,Martinez N,Centorbi O,O'Ryan M,Jackson L,Campos F,Matson DO

    更新日期:2000-08-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470418

    authors: Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期:1995-12-01 00:00:00

  • Experimental infection of nonenveloped DNA virus (TTV) in rhesus monkey.

    abstract::Virus fragments homologous to TTV were detected previously from an enterically transmitted outbreak of non-A-E hepatitis [Luo et al., 1999]. To test the susceptibility of the Rhesus monkey to this virus and to establish its transmission routes, 6 Rhesus monkeys were inoculated, 3 orally and another 3 intravenously. Th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26

    authors: Luo K,Liang W,He H,Yang S,Wang Y,Xiao H,Liu D,Zhang L

    更新日期:2000-05-01 00:00:00

  • Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.

    abstract::Virus variants escaping from host immunity may be implicated in the pathogenesis of hepatitis B virus (HBV) infection. In this cross-sectional study, the association was evaluated of the frequency of amino acid variation within the immunogenic epitopes of surface gene with different disease stages of chronic HBV infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10169

    authors: Liu CJ,Kao JH,Shau WY,Chen PJ,Lai MY,Chen DS

    更新日期:2002-09-01 00:00:00

  • Prevalence and risk factors of hepatitis B virus infection in Middle-Limburg Belgium, year 2017: Importance of migration.

    abstract:BACKGROUND AND AIM:The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limb...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25457

    authors: Koc ÖM,Kremer C,Bielen R,Buscchots D,Hens N,Nevens F,Robaeys G

    更新日期:2019-08-01 00:00:00

  • Reactivation of human herpesvirus 6 by infection of human herpesvirus 7.

    abstract::We have attempted to reactivate human herpesvirus 6 (HHV-6) by infection with HHV-7 using childhood exanthem subitum patients in vitro. Peripheral blood mononuclear cells (PBMCs) were collected from children who had a history of exanthem subitum(ES) by HHV-6 and were infected by human herpesvirus 7 (HHV-7) in vitro. T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200003)60:3<284::aid-jmv6>

    authors: Tanaka-Taya K,Kondo T,Nakagawa N,Inagi R,Miyoshi H,Sunagawa T,Okada S,Yamanishi K

    更新日期:2000-03-01 00:00:00

  • High prevalence of hepatitis delta virus infection detectable by enzyme immunoassay among apparently healthy individuals in Mongolia.

    abstract::A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20363

    authors: Inoue J,Takahashi M,Nishizawa T,Narantuya L,Sakuma M,Kagawa Y,Shimosegawa T,Okamoto H

    更新日期:2005-07-01 00:00:00

  • Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China.

    abstract::Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 201...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25222

    authors: Chen X,Shi T,Huang J,Xiao G,Huang J,Xiong Y,Li X,Chen H,Zheng X,Yu S,Chen Q

    更新日期:2018-09-01 00:00:00

  • Intestinal immunity to poliovirus develops only after repeated infections in monkeys.

    abstract::To establish gut immunity in monkeys to polio-virus type 1, we fed four juvenile bonnet monkeys (Macaca radiata) with 100 median infectious doses of the Mahoney strain of virus. The duration of viral shedding in the throat and faeces and the titre of virus in faeces were measured. Eighteen days after the last monkey s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890270208

    authors: Selvakumar R,John TJ

    更新日期:1989-02-01 00:00:00

  • Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay.

    abstract::Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24621

    authors: Inazawa N,Hori T,Nojima M,Saito M,Igarashi K,Yamamoto M,Shimizu N,Yoto Y,Tsutsumi H

    更新日期:2017-02-01 00:00:00

  • Association of rhinovirus with exacerbations in young children affected by cystic fibrosis: Preliminary data.

    abstract::Rhinovirus (RV) is a common respiratory viral infection linked to worsening of chronic respiratory diseases including cystic fibrosis (CF) and asthma. RV was tested by RT-PCR in samples (n = 465) collected from the upper (nasal swab, oropharyngeal suction, and sputum) and lower (bronchoalveolar washings) respiratory t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24794

    authors: Stelzer-Braid S,Liu N,Doumit M,D'Cunha R,Belessis Y,Jaffe A,Rawlinson WD

    更新日期:2017-08-01 00:00:00

  • Large scale study of HPV genotypes in cervical cancer and different cytological cervical specimens in Thailand.

    abstract::Identification of high-risk HPV genotypes in patients is essential for vaccination and prevention programs while the geographic distribution of cervical cancer varies widely. HPV 16 is the major cause of cervical cancer followed by HPV 18, HPV 31, HPV 52, or HPV 58 depending on geographic area. In this study, the dist...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23769

    authors: Chansaenroj J,Junyangdikul P,Chinchai T,Swangvaree S,Karalak A,Gemma N,Poovorawan Y

    更新日期:2014-04-01 00:00:00